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Whole-Genome Sequencing of Staphylococcus aureus Strain RN4220, a Key Laboratory Strain Used in Virulence Research, Identifies Mutations That Affect Not Only Virulence Factors but Also the Fitness of the Strain
Open accessAbstract
Staphylococcus aureus RN4220, a cloning intermediate, is sometimes used in virulence, resistance, and metabolic studies. Using whole-genome sequencing, we showed that RN4220 differs from NCTC8325 and contains a number of genetic polymorphisms that affect both virulence and general fitness, implying a need for caution in using this strain for such studies.
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Versatile and open software for comparing large genomes
Kurtz, S., Phillippy, A., Delcher, A. L., Smoot, M., Shumway, M., Antonescu, C., & Salzberg, S. L. (2004) · Genome Biology · doi:10.1186/gb-2004-5-2-r12 · Cited by 5,254
Prokaryotic Nucleotide Excision Repair: The UvrABC System
Truglio, J. J., Croteau, D. L., Van Houten, B., & Kisker, C. (2006) · Chemical Reviews · doi:10.1021/cr040471u · Cited by 340
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Metadata
- Authors
- Nair, D., Memmi, G., Hernandez, D., Bard, J., Beaume, M., Gill, S., Francois, P., & Cheung, A. L.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2011-05
- Volume
- 193
- Issue
- 9
- Pages
- 2332-2335
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2118969738
- Cited by
- 204
- References
- 2
- FWCI
- 9.41
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Whole-Genome Sequencing of Staphylococcus aureus Strain RN4220, a Key Laboratory Strain Used in Virulence Research, Identifies Mutations That Affect Not Only Virulence Factors but Also the Fitness of the Strain. https://app.cochat.ai/papers/10.1128/jb.00027-11
- The paper
- Nair, D., Memmi, G., Hernandez, D., Bard, J., Beaume, M., Gill, S., Francois, P., & Cheung, A. L. (2011). Whole-Genome Sequencing of Staphylococcus aureus Strain RN4220, a Key Laboratory Strain Used in Virulence Research, Identifies Mutations That Affect Not Only Virulence Factors but Also the Fitness of the Strain. Journal of Bacteriology. https://doi.org/10.1128/jb.00027-11
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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