The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Direct Targets of CodY in Staphylococcus aureus
Open accessAbstract
More than 200 direct CodY target genes in Staphylococcus aureus were identified by genome-wide analysis of in vitro DNA binding. This analysis, which was confirmed for some genes by DNase I footprinting assays, revealed that CodY is a direct regulator of numerous transcription units associated with amino acid biosynthesis, transport of macromolecules, and virulence. The virulence genes regulated by CodY fell into three groups. One group was dependent on the Agr system for its expression; these genes were indirectly regulated by CodY through its repression of the agr locus. A second group was regulated directly by CodY. The third group, which includes genes for alpha-toxin and capsule synthesis, was regulated by CodY in two ways, i.e., by direct repression and by repression of the agr locus. Since S. aureus CodY was activated in vitro by the branched chain amino acids and GTP, CodY appears to link changes in intracellular metabolite pools with the induction of numerous adaptive responses, including virulence.
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“Some studies have shown that CodY may bind to a locus in agrC in vitro [121,122], but this binding does not affect the in vivo transcription of agrA, suggesting that CodY does not control agr gene expression through direct binding within the agr locus [122].”
From A Review of Biofilm Formation of Staphylococcus aureus and Its Regulation Mechanism (2022) · cites this paper as [121]
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Richardson, A. R., Libby, S. J., & Fang, F. C. (2008) · Science · doi:10.1126/science.1155207 · Cited by 296
Somerville, G. A., Chaussee, M. S., Morgan, C. I., Fitzgerald, J. R., Dorward, D. W., Reitzer, L. J., & Musser, J. M. (2002) · Infection and Immunity · doi:10.1128/iai.70.11.6373-6382.2002 · Cited by 196
Self-citationComparative Genomics of Staphylococcus aureus Musculoskeletal Isolates
Cassat, J. E., Dunman, P. M., McAleese, F., Murphy, E., Projan, S. J., & Smeltzer, M. S. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.2.576-592.2005 · Cited by 112
Cited by
Metabolite-enabled eradication of bacterial persisters by aminoglycosides
Allison, K. R., Brynildsen, M. P., & Collins, J. J. (2011) · Nature · doi:10.1038/nature10069 · Cited by 1,025
Regulation of Staphylococcus aureus Virulence
Jenul, C., & Horswill, A. R. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0031-2018 · Cited by 549
A Review of Biofilm Formation of Staphylococcus aureus and Its Regulation Mechanism
Peng, Q., Tang, X., Dong, W., Sun, N., & Yuan, W. (2022) · Antibiotics · doi:10.3390/antibiotics12010012 · Cited by 440
Peptide Signaling in the Staphylococci
Thoendel, M., Kavanaugh, J. S., Flack, C. E., & Horswill, A. R. (2011) · Chemical Reviews · doi:10.1021/cr100370n · Cited by 438
The stringent response and physiological roles of (pp)pGpp in bacteria.
Irving, S. E., Choudhury, N. R., & Corrigan, R. M. (2021) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00470-y · Cited by 413
Metadata
- Authors
- Majerczyk, C. D., Dunman, P. M., Luong, T. T., Lee, C. Y., Sadykov, M. R., Somerville, G. A., Bodi, K., & Sonenshein, A. L.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2010-06
- Volume
- 192
- Issue
- 11
- Pages
- 2861-2877
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2155568318
- Cited by
- 221
- References
- 3
- FWCI
- 9.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Majerczyk, C. D., Dunman, P. M., Luong, T. T., Lee, C. Y., Sadykov, M. R., Somerville, G. A., Bodi, K., & Sonenshein, A. L. (2010). Direct Targets of CodY in Staphylococcus aureus. Journal of Bacteriology. https://doi.org/10.1128/jb.00220-10
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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