Comparative Genomics of Staphylococcus aureus Musculoskeletal Isolates

Cassat, James E.; Dunman, Paul M.; McAleese, Fionnuala; Murphy, Ellen; Projan, Steven J.; Smeltzer, Mark S.

doi:10.1128/jb.187.2.576-592.2005

Cited by 112Antimicrobial Resistance in StaphylococcusStreptococcal Infections and TreatmentsOrthopedic Infections and Treatments

Comparative Genomics of Staphylococcus aureus Musculoskeletal Isolates

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Cassat, James E., Dunman, Paul M., McAleese, Fionnuala, Murphy, Ellen, Projan, Steven J., Smeltzer, Mark S.·2005·Journal of Bacteriology

DOI 10.1128/jb.187.2.576-592.2005PMC PMC543526

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Abstract

Much of the research aimed at defining the pathogenesis of Staphylococcus aureus has been done with a limited number of strains, most notably the 8325-4 derivative RN6390. Several lines of evidence indicate that this strain is unique by comparison to clinical isolates of S. aureus. Based on this, we have focused our efforts on two clinical isolates (UAMS-1 and UAMS-601), both of which are hypervirulent in our animal models of musculoskeletal infection. In this study, we used comparative genomic hybridization to assess the genome content of these two isolates relative to RN6390 and each of seven sequenced S. aureus isolates. Our comparisons were done by using an amplicon-based microarray from the Pathogen Functional Genomics Resource Center and an Affymetrix GeneChip that collectively represent the genomes of all seven sequenced strains. Our results confirmed that UAMS-1 and UAMS-601 share specific attributes that distinguish them from RN6390. Potentially important differences included the presence of cna and the absence of isaB, sarT, sarU, and sasG in the UAMS isolates. Among the sequenced strains, the UAMS isolates were most closely related to the dominant European clone EMRSA-16. In contrast, RN6390, NCTC 8325, and COL formed a distinct cluster that, by comparison to the other four sequenced strains (Mu50, N315, MW2, and SANGER-476), was the most distantly related to the UAMS isolates and EMRSA-16.

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Of the virulence factors surveyed for this study, only PVL is present in the strain that expressed high virulence following influenza, NRS-193, but is absent in the strains that did not, ATCC 27733 and UAMS-1.
“of the virulence factors surveyed for this study, only PVL is present in the strain that expressed high virulence following influenza, NRS-193, but is absent in the strains that did not, ATCC 27733 (Table 1) and UAMS-1 [49].”
From Influenza virus primes mice for pneumonia from Staphylococcus aureus. (2011) · cites this paper as [49]

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Comparative Genomics of Staphylococcus aureus
Cassat, J. E., Dunman, P. M., Mcaleese, F., Murphy, E., Projan, S. J., Smeltzer, M. S., Isolates, M., Cassat, J. E., Dunman, P. M., Mcaleese, F., et al. (2004)
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RESEARCH ARTICLE Open Access Comparative supragenomic analyses among the pathogens Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae Using a modification of the finite supragenome model
Boissy, R., Ahmed, A., Janto, B., Earl, J., Hall, B. G., Hogg, J., Pusch, G. D., Hiller, L. N., Powell, E., Hayes, J. D., et al. (2013)
Correspondence
Sung, J. M. L., Lloyd, D. H., Lindsay, J. A., & Lindsay, J. A. (2008)

Authors: Cassat, J. E., Dunman, P. M., McAleese, F., Murphy, E., Projan, S. J., & Smeltzer, M. S.
Affiliations: University of Arkansas for Medical Sciences (US)
Wyeth (US)
Wyeth Research, Cambridge, Massachusetts
Corresponding author: Smeltzer, Mark S.
ORCID: Cassat, James E.
Dunman, Paul M.
Smeltzer, Mark S.
Venue: Journal of Bacteriology
Publisher: American Society for Microbiology
Published: 2005-01-15
Volume: 187
Issue: 2
Pages: 576-592
ISSN: 0021-9193 (ISSN-L)
1098-5530
DOI: 10.1128/jb.187.2.576-592.2005
PMC: PMC543526
OpenAlex: W2061688904
Cited by: 112
References: 70
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 7 · 2015: 8 · 2014: 5 · 2013: 4 · 2012: 8
FWCI: 7.68
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Bacteriology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01AI043356)
Topics: Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Streptococcal Infections and Treatments
Health Sciences › Medicine › Surgery › Orthopedic Infections and Treatments
Keywords: Staphylococcus aureus, bone and joint infections, comparative genomics, EMRSA-16, SART, strain phylogeny, virulence genes
MeSH terms: Antigens, Bacterial, Bacterial Proteins, DNA-Binding Proteins, DNA, Bacterial, Genes, Bacterial, Nucleic Acid Hybridization, Phylogeny, Repressor Proteins, Staphylococcal Infections, Staphylococcus aureus, Genome, Bacterial, Muscle, Skeletal, Adhesins, Bacterial, Genomics

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Comparative Genomics of Staphylococcus aureus Musculoskeletal Isolates

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