The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
The Peptidoglycan of Stationary-Phase Mycobacterium tuberculosis Predominantly Contains Cross-Links Generated by l,d -Transpeptidation
Open accessAbstract
Our understanding of the mechanisms used by Mycobacterium tuberculosis to persist in a “dormant” state is essential to the development of therapies effective in sterilizing tissues. Gene expression profiling in model systems has revealed a complex adaptive response thought to endow M. tuberculosis with the capacity to survive several months of combinatorial antibiotic treatment. We show here that this adaptive response may involve remodeling of the peptidoglycan network by substitution of 4→3 cross-links generated by the d , d -transpeptidase activity of penicillin-binding proteins by 3→3 cross-links generated by a transpeptidase of l,d specificity. A candidate gene, previously shown to be upregulated upon nutrient starvation, was found to encode an l,d -transpeptidase active in the formation of 3→3 cross-links. The enzyme, Ldt Mt1 , was inactivated by carbapenems, a class of β-lactam antibiotics that are poorly hydrolyzed by the M. tuberculosis β-lactamases. Ldt Mt1 and carbapenems may therefore represent a target and a drug family relevant to the eradication of persistent M. tuberculosis .
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Inhibition of Respiration by Nitric Oxide Induces a Mycobacterium tuberculosis Dormancy Program
Voskuil, M. I., Schnappinger, D., Visconti, K. C., Harrell, M. I., Dolganov, G. M., Sherman, D. R., & Schoolnik, G. K. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030205 · Cited by 966
Nonreplicating Persistence of Mycobacterium Tuberculosis
Wayne, L. G., & Sohaskey, C. D. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.139 · Cited by 807
Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding α-crystallin
Sherman, D. R., Voskuil, M., Schnappinger, D., Liao, R., Harrell, M. I., & Schoolnik, G. K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121172498 · Cited by 729
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Latent Mycobacterium tuberculosis–persistence, patience and winning by waiting
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A Novel Peptidoglycan Cross-linking Enzyme for a β-Lactam-resistant Transpeptidation Pathway
Mainardi, J.-L., Fourgeaud, M., Hugonnet, J.-E., Dubost, L., Brouard, J.-P., Ouazzani, J., Rice, L. B., Gutmann, L., & Arthur, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507384200 · Cited by 225
Self-citationIrreversible Inhibition of the Mycobacterium tuberculosis β-Lactamase by Clavulanate
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Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis
Hugonnet, J.-E., Tremblay, L. W., Boshoff, H. I., Barry, C. E., & Blanchard, J. S. (2009) · Science · doi:10.1126/science.1167498 · Cited by 494
Cell Wall Structure and Function in Lactic Acid Bacteria
Chapot-Chartier, M.-P., & Kulakauskas, S. (2014) · Microbial Cell Factories · doi:10.1186/1475-2859-13-s1-s9 · Cited by 410
The Normalcy of Dormancy: Common Themes in Microbial Quiescence
Rittershaus, E. S. C., Baek, S.-H., & Sassetti, C. M. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.05.012 · Cited by 340
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Metadata
- Authors
- Lavollay, M., Arthur, M., Fourgeaud, M., Dubost, L., Marie, A., Veziris, N., Blanot, D., Gutmann, L., & Mainardi, J.-L.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2008-06-15
- Volume
- 190
- Issue
- 12
- Pages
- 4360-4366
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2105475356
- Cited by
- 349
- References
- 27
- FWCI
- 7.62
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The Peptidoglycan of Stationary-Phase Mycobacterium tuberculosis Predominantly Contains Cross-Links Generated by l,d -Transpeptidation. https://app.cochat.ai/papers/10.1128/jb.00239-08
- The paper
- Lavollay, M., Arthur, M., Fourgeaud, M., Dubost, L., Marie, A., Veziris, N., Blanot, D., Gutmann, L., & Mainardi, J.-L. (2008). The Peptidoglycan of Stationary-Phase Mycobacterium tuberculosis Predominantly Contains Cross-Links Generated by l,d -Transpeptidation. Journal of Bacteriology. https://doi.org/10.1128/jb.00239-08
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