The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis
Open accessAbstract
β-lactam antibiotics are ineffective against Mycobacterium tuberculosis , being rapidly hydrolyzed by the chromosomally encoded blaC gene product. The carbapenem class of β-lactams are very poor substrates for BlaC, allowing us to determine the three-dimensional structure of the covalent BlaC-meropenem covalent complex at 1.8 angstrom resolution. When meropenem was combined with the β-lactamase inhibitor clavulanate, potent activity against laboratory strains of M. tuberculosis was observed [minimum inhibitory concentration (MIC meropenem ) less than 1 microgram per milliliter], and sterilization of aerobically grown cultures was observed within 14 days. In addition, this combination exhibited inhibitory activity against anaerobically grown cultures that mimic the “persistent” state and inhibited the growth of 13 extensively drug-resistant strains of M. tuberculosis at the same levels seen for drug-susceptible strains. Meropenem and clavulanate are Food and Drug Administration–approved drugs and could potentially be used to treat patients with currently untreatable disease.
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Cites
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Irreversible Inhibition of the Mycobacterium tuberculosis β-Lactamase by Clavulanate
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Cited by
Antibiotic resistance-the need for global solutions
Laxminarayan, R., Duse, A., Wattal, C., Zaidi, A. K. M., Wertheim, H. F. L., Sumpradit, N., Vlieghe, E., Hara, G. L., Gould, I. M., Goossens, H., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70318-9 · Cited by 4,439
Three Decades of β-Lactamase Inhibitors
Drawz, S. M., & Bonomo, R. A. (2010) · Clinical Microbiology Reviews · doi:10.1128/cmr.00037-09 · Cited by 1,709
Carbapenems: Past, Present, and Future
Papp-Wallace, K. M., Endimiani, A., Taracila, M. A., & Bonomo, R. A. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00296-11 · Cited by 1,502
The challenge of new drug discovery for tuberculosis
Koul, A., Arnoult, E., Lounis, N., Guillemont, J., & Andries, K. (2011) · Nature · doi:10.1038/nature09657 · Cited by 1,042
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Metadata
- Authors
- Hugonnet, J.-E., Tremblay, L. W., Boshoff, H. I., Barry, C. E., & Blanchard, J. S.
- Venue
- Science
- Published
- 2009-02-27
- Volume
- 323
- Issue
- 5918
- Pages
- 1215-1218
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2071973715
- Cited by
- 494
- References
- 16
- FWCI
- 28.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Hugonnet, J.-E., Tremblay, L. W., Boshoff, H. I., Barry, C. E., & Blanchard, J. S. (2009). Meropenem-Clavulanate Is Effective Against Extensively Drug-Resistant Mycobacterium tuberculosis. Science. https://doi.org/10.1126/science.1167498
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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