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Nature of Col E 1 Plasmid Replication in Escherichia coli in the Presence of Chloramphenicol
Open accessAbstract
The colicinogenic factor E 1 (Col E 1 ) in Escherichia coli continues to replicate by a semiconservative mechanism in the presence of chloramphenicol (CAP) for 10 to 15 hr, long after chromosomal deoxyribonucleic acid (DNA) synthesis has terminated. Following CAP addition, the rate of synthesis of plasmid DNA gradually increases to an extent dependent on the medium employed. Within 2 to 4 hr after the addition of CAP, replication in a glucose-Casamino Acids medium approaches a maximum rate representing approximately eight times an average rate which would be required for a net doubling of DNA per cell in one generation. The number of copies of Col E 1 DNA molecules that accumulate under these conditions approaches about 3,000 copies per cell, representing a 125-fold increase over the normal level of 24 copies per cell. The system is particularly convenient for studying the mechanism of DNA replication.
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Citations
Cites
Burton, K. (1956) · Biochemical Journal · doi:10.1042/bj0620315 · Cited by 14,090
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Birnboim, H. C., & Doly, J. (1979) · Nucleic Acids Research · doi:10.1093/nar/7.6.1513 · Cited by 14,686
Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis
Fried, M., & Crothers, D. M. (1981) · Nucleic Acids Research · doi:10.1093/nar/9.23.6505 · Cited by 2,738
Rushmore, T. H., Morton, M. R., & Pickett, C. B. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99004-6 · Cited by 1,464
Transformation of yeast by a replicating hybrid plasmid
Beggs, J. D. (1978) · Nature · doi:10.1038/275104a0 · Cited by 1,316
Expression in Escherichia coli of chemically synthesized genes for human insulin.
Goeddel, D. V., Kleid, D. G., Bolivar, F., Heyneker, H. L., Yansura, D. G., Crea, R., Hirose, T., Kraszewski, A., Itakura, K., & Riggs, A. D. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.1.106 · Cited by 869
Metadata
- Authors
- Clewell, D. B.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1972-05
- Volume
- 110
- Issue
- 2
- Pages
- 667-676
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W1858120728
- Cited by
- 1,184
- References
- 1
- FWCI
- 15.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Clewell, D. B. (1972). Nature of Col E 1 Plasmid Replication in Escherichia coli in the Presence of Chloramphenicol. Journal of Bacteriology. https://doi.org/10.1128/jb.110.2.667-676.1972
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
