The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Physiological regulation of a decontrolled lac operon
Open accessAbstract
The expression of the lac operon was studied under a variety of growth conditions in induced and in constitutive cells of Escherichia coli that carried different catabolite-insensitive lac promoters. Use of such "decontrolled" lac operons permitted a study of the expression of an operon that was presumably subject only to passive control. Since the use of toluenized cells was demonstrated not to be completely reliable, all enzyme assays were performed on sonic supernatant fluids. The cells contained different catabolite-insensitive promoters, which included the L1 and UV5 lac promoters, as well as others isolated in this study. There were three major observations. First, small but real carbon source effects were seen. Second, there was only a small change in beta-galactosidase specific activity with changes in the growth rate. This result implies a limited transcription and/or translation capacity within the cell. Third, at rapid growth rates, most promoters exhibited a decreased expression. The UV5 promoter, which was the "strongest" promoter, was an exception. A mechanism to explain this promoter-dependent control is discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Macromolecular Composition During Steady-State Growth of Escherichia coli B/r
Dennis, P. P., & Bremer, H. (1974) · Journal of Bacteriology · doi:10.1128/jb.119.1.270-281.1974 · Cited by 196
Cited by
Growth Rate-Dependent Global Effects on Gene Expression in Bacteria
Klumpp, S., Zhang, Z., & Hwa, T. (2009) · Cell · doi:10.1016/j.cell.2009.12.001 · Cited by 703
Induction of proteins in response to low temperature in Escherichia coli
Jones, P. G., VanBogelen, R. A., & Neidhardt, F. C. (1987) · Journal of Bacteriology · doi:10.1128/jb.169.5.2092-2095.1987 · Cited by 613
The global, ppGpp‐mediated stringent response to amino acid starvation in Escherichia coli
Traxler, M. F., Summers, S. M., Nguyen, H., Zacharia, V. M., Hightower, G. A., Smith, J. T., & Conway, T. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06229.x · Cited by 517
ATP-Dependent Persister Formation in Escherichia coli
Shan, Y., Brown Gandt, A., Rowe, S. E., Deisinger, J. P., Conlon, B. P., & Lewis, K. (2017) · mBio · doi:10.1128/mbio.02267-16 · Cited by 508
Characterization of the cytoplasm of Escherichia coli K-12 as a function of external osmolarity
Cayley, S., Lewis, B. A., Guttman, H. J., & Record, M. T. (1991) · Journal of Molecular Biology · doi:10.1016/0022-2836(91)90212-o · Cited by 486
Metadata
- Authors
- Wanner, B. L., Kodaira, R., & Neidhart, F. C.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1977-04
- Volume
- 130
- Issue
- 1
- Pages
- 212-222
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W1841558112
- Cited by
- 166
- References
- 1
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Physiological regulation of a decontrolled lac operon. https://app.cochat.ai/papers/10.1128/jb.130.1.212-222.1977
- The paper
- Wanner, B. L., Kodaira, R., & Neidhart, F. C. (1977). Physiological regulation of a decontrolled lac operon. Journal of Bacteriology. https://doi.org/10.1128/jb.130.1.212-222.1977
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
