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Products of the iron-molybdenum cofactor-specific biosynthetic genes, nifE and nifN, are structurally homologous to the products of the nitrogenase molybdenum-iron protein genes, nifD and nifK
Open accessAbstract
The genes from Azotobacter vinelandii, which are homologous to the iron-molybdenum cofactor biosynthetic genes, nifE and nifN, from Klebsiella pneumoniae, have been cloned and sequenced. These genes comprise a single transcription unit and are located immediately downstream from the nitrogenase structural gene cluster (nifHDK). DNA sequence analysis has revealed that the products of the nifE and nifN genes contain considerable homology when compared with the nifD (MoFe protein alpha subunit) and the nifK (MoFe protein beta subunit) gene products, respectively. These striking sequence homologies indicate a structural and functional relationship between a proposed nifEN product complex and the nitrogenase MoFe protein as well as imply an ancestral relationship between these gene clusters. The isolation and characterization of strains which contain deletions within the nifEN gene cluster demonstrate a role for these products in iron-molybdenum cofactor biosynthesis in A. vinelandii.
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Citations
Cited by
Structural basis of biological nitrogen fixation
Rees, D. C., Akif Tezcan, F., Haynes, C. A., Walton, M. Y., Andrade, S., Einsle, O., & Howard, J. B. (2005) · Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences · doi:10.1098/rsta.2004.1539 · Cited by 1,120
Structural Basis of Biological Nitrogen Fixation
Howard, J. B., & Rees, D. C. (1996) · Chemical Reviews · doi:10.1021/cr9500545 · Cited by 1,044
Biochemical and genetic analysis of the nifUSVWZM cluster from Azotobacter vinelandii
Jacobson, M. R., Cash, V. L., Weiss, M. C., Laird, N. F., Newton, W. E., & Dean, D. R. (1989) · Molecular and General Genetics MGG · doi:10.1007/bf00261156 · Cited by 329
Self-citationA late methanogen origin for molybdenum-dependent nitrogenase
BOYD, E. S., ANBAR, A. D., MILLER, S., HAMILTON, T. L., LAVIN, M., & PETERS, J. W. (2011) · Geobiology · doi:10.1111/j.1472-4669.2011.00278.x · Cited by 161
Parsons, C., Stüeken, E. E., Rosen, C. J., Mateos, K., & Anderson, R. E. (2021) · Geobiology · doi:10.1111/gbi.12419 · Cited by 91
Metadata
- Authors
- Brigle, K. E., Weiss, M. C., Newton, W. E., & Dean, D. R.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1987-04
- Volume
- 169
- Issue
- 4
- Pages
- 1547-1553
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W1560917766
- Cited by
- 172
- References
- 0
- FWCI
- 23.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Products of the iron-molybdenum cofactor-specific biosynthetic genes, nifE and nifN, are structurally homologous to the products of the nitrogenase molybdenum-iron protein genes, nifD and nifK. https://app.cochat.ai/papers/10.1128/jb.169.4.1547-1553.1987
- The paper
- Brigle, K. E., Weiss, M. C., Newton, W. E., & Dean, D. R. (1987). Products of the iron-molybdenum cofactor-specific biosynthetic genes, nifE and nifN, are structurally homologous to the products of the nitrogenase molybdenum-iron protein genes, nifD and nifK. Journal of Bacteriology. https://doi.org/10.1128/jb.169.4.1547-1553.1987
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