The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The genes for butanol and acetone formation in Clostridium acetobutylicum ATCC 824 reside on a large plasmid whose loss leads to degeneration of the strain
Open accessAbstract
Degeneration is the process whereby Clostridium acetobutylicum ATCC 824 loses the capacity to produce acetone and butanol after repeated vegetative transfers or in continuous culture. Two degenerate mutants (M5 and DG1) of C. acetobutylicum ATCC 824 do not contain the four genes (ctfA, ctfB, adc, and aad) for acetone and butanol formation. Strain ATCC 824 contains a 210-kb plasmid (pSOL1) which is absent in M5 and DG1. pSOL1 carries the four acetone and butanol formation genes. A restriction map of pSOL1 was constructed by using ApaI, SmaI, SstII, and NarI digestions. M5 and DG1 could be complemented for acetone and butanol formation by expressing the corresponding genes (ctfA, ctfB, and adc for acetone; aad for butanol) on the plasmid. Degeneration of this strain thus appears to be the result of pSOL1 loss.
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Citations
Cites
Introduction of plasmids into whole cells of Clostridium acetobutylicum by electroporation
Oultram, J. D., Loughlin, M., Swinfield, T.-J., Brehm, J. K., Thompson, D. E., & Minton, N. P. (1988) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1988.tb03154.x · Cited by 133
Cited by
Nölling, J., Breton, G., Omelchenko, M. V., Makarova, K. S., Zeng, Q., Gibson, R., Lee, H. M., Dubois, J., Qiu, D., Hitti, J., et al. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.16.4823-4838.2001 · Cited by 770
Self-citationExpression of Clostridium acetobutylicum butanol synthetic genes in Escherichia coli
Inui, M., Suda, M., Kimura, S., Yasuda, K., Suzuki, H., Toda, H., Yamamoto, S., Okino, S., Suzuki, N., & Yukawa, H. (2008) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-007-1257-5 · Cited by 353
A comparative genomic view of clostridial sporulation and physiology
Paredes, C. J., Alsaker, K. V., & Papoutsakis, E. T. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1288 · Cited by 342
Self-citationEngineering solventogenic clostridia
Papoutsakis, E. T. (2008) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2008.08.003 · Cited by 332
Self-citationTummala, S. B., Welker, N. E., & Papoutsakis, E. T. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.6.1923-1934.2003 · Cited by 174
Metadata
- Authors
- Cornillot, E., Nair, R. V., Papoutsakis, E. T., & Soucaille, P.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1997-09
- Volume
- 179
- Issue
- 17
- Pages
- 5442-5447
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2128146431
- Cited by
- 208
- References
- 1
- FWCI
- 1.35
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: The genes for butanol and acetone formation in Clostridium acetobutylicum ATCC 824 reside on a large plasmid whose loss leads to degeneration of the strain. https://app.cochat.ai/papers/10.1128/jb.179.17.5442-5447.1997
- The paper
- Cornillot, E., Nair, R. V., Papoutsakis, E. T., & Soucaille, P. (1997). The genes for butanol and acetone formation in Clostridium acetobutylicum ATCC 824 reside on a large plasmid whose loss leads to degeneration of the strain. Journal of Bacteriology. https://doi.org/10.1128/jb.179.17.5442-5447.1997
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