Heme compounds as iron sources for nonpathogenic Rhizobium bacteria
Open accessAbstract
Many animal-pathogenic bacteria can use heme compounds as iron sources. Like these microorganisms, rhizobium strains interact with host organisms where heme compounds are available. Results presented in this paper indicate that the use of hemoglobin as an iron source is not restricted to animal-pathogenic microorganisms. We also demonstrate that heme, hemoglobin, and leghemoglobin can act as iron sources under iron-depleted conditions for Rhizobium meliloti 242. Analysis of iron acquisition mutant strains indicates that siderophore-, heme-, hemoglobin-, and leghemoglobin-mediated iron transport systems expressed by R. meliloti 242 share at least one component.
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B. japonicum obtains heme from leghemoglobin inside plant nodules, and leghemoglobin can make up as much as 30% of soluble protein in those nodules.
“Within these nodules B. japonicum acquires heme from leghemoglobin, a plant hemoglobin with structural properties similar to animal hemoglobins that can comprise up to 30% of the total soluble protein within plant nodules [59].”
From A battle for iron: host sequestration and Staphylococcus aureus acquisition (2012) · cites this paper as [59]
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A battle for iron: host sequestration and Staphylococcus aureus acquisition
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“japonicum acquires heme from leghemoglobin, a plant hemoglobin with structural properties similar to animal hemoglobins that can comprise up to 30% of the total soluble protein within plant nodules [59].”
BackgroundProcessing of Heme and Heme-Containing Proteins by Bacteria
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- Authors
- Noya, F., Arias, A., & Fabiano, E.
- Affiliations
- Instituto de Investigaciones Biológicas Clemente Estable (UY)
- ORCID
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1997-05
- Volume
- 179
- Issue
- 9
- Pages
- 3076-3078
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- PMC
- PMC179080
- OpenAlex
- W2119169154
- Cited by
- 55
- References
- 27
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 1 · 2019: 1 · 2018: 2 · 2016: 3 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Bacteriology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Legume Nitrogen Fixing Symbiosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hemoglobin structure and function
- Keywords
- hemoglobin, leghemoglobin, Sinorhizobium meliloti, siderophores, iron transport systems, iron starvation, host-microbe interactions
- MeSH terms
- Animals, Bacteria, Biological Transport, Cattle, Culture Media, Ethylenediamines, Heme, Hemoglobins, Iron, Iron Chelating Agents, Leghemoglobin, Rhizobiaceae, Rhizobium, Species Specificity, Sinorhizobium meliloti
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