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Ras Signaling Is Required for Serum-Induced Hyphal Differentiation in Candida albicans
Open accessAbstract
Serum induces Candida albicans to make a rapid morphological change from the yeast cell form to hyphae. Contrary to the previous reports, we found that serum albumin does not play a critical role in this morphological change. Instead, a filtrate (molecular mass, <1 kDa) devoid of serum albumin induces hyphae. To study genes controlling this response, we have isolated the RAS1 gene from C. albicans by complementation. The Candida Ras1 protein, like Ras1 and Ras2 of Saccharomyces cerevisiae , has a long C-terminal extension. Although RAS1 appears to be the only RAS gene present in the C. albicans genome, strains homozygous for a deletion of RAS1 ( ras1-2/ras1-3 ) are viable. The Candida ras1-2/ras1-3 mutant fails to form germ tubes and hyphae in response to serum or to a serum filtrate but does form pseudohyphae. Moreover, strains expressing the dominant active RAS1 V13 allele manifest enhanced hyphal growth, whereas those expressing a dominant negative RAS1 A16 allele show reduced hyphal growth. These data show that low-molecular-weight molecules in serum induce hyphal differentiation in C. albicans through a Ras-mediated signal transduction pathway.
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Cited by
Virulence factors of Candida albicans
Calderone, R. A., & Fonzi, W. A. (2001) · Trends in Microbiology · doi:10.1016/s0966-842x(01)02094-7 · Cited by 1,331
Growth of Candida albicans hyphae
Sudbery, P. E. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2636 · Cited by 1,110
Signal Transduction Cascades Regulating Fungal Development and Virulence
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Candida albicans morphogenesis and host defence: discriminating invasion from colonization
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Metadata
- Authors
- Feng, Q., Summers, E., Guo, B., & Fink, G.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1999-10-15
- Volume
- 181
- Issue
- 20
- Pages
- 6339-6346
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2163110564
- Cited by
- 346
- References
- 24
- FWCI
- 5.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- journals.asm.org/non-commercial-tdm-license (tdm)
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- Feng, Q., Summers, E., Guo, B., & Fink, G. (1999). Ras Signaling Is Required for Serum-Induced Hyphal Differentiation in Candida albicans. Journal of Bacteriology. https://doi.org/10.1128/jb.181.20.6339-6346.1999
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