The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
RsaL, a Novel Repressor of Virulence Gene Expression in Pseudomonas aeruginosa
Open accessAbstract
As components of a Pseudomonas aeruginosa quorum-sensing system, LasR and PAI-1 globally regulate expression of multiple virulence determinants, as well as the second P. aeruginosa quorum-sensing system. To date, no information exists on negative regulation of the quorum-sensing cascade in P. aeruginosa. Here we describe a novel gene, rsaL , which is located downstream from lasR and transcribed antisense relative to lasR. In P. aeruginosa, overexpression of rsaL results in reduced lasB expression and decreased elastase activity. With the use of a six-His protein fusion system, we demonstrate that rsaL encodes an 11-kDa protein. Direct quantitation of PAI-1 levels in cultures and studies utilizing Escherichia coli lambda lysogens carrying lacZ transcriptional fusions reveal that RsaL specifically represses transcription of the PAI-1 autoinducer synthase gene, lasI . RsaL’s repressive effect on lasI and the associated decrease in elastase activity have important implications for the expression of all LasR–PAI-1-dependent virulence genes and the overall pathogenicity of P. aeruginosa.
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Citations
Cites
The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
Davies, D. G., Parsek, M. R., Pearson, J. P., Iglewski, B. H., Costerton, J. W., & Greenberg, E. P. (1998) · Science · doi:10.1126/science.280.5361.295 · Cited by 3,396
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Biofilms as Complex Differentiated Communities
Stoodley, P., Sauer, K., Davies, D. G., & Costerton, J. W. (2002) · Annual Review of Microbiology · doi:10.1146/annurev.micro.56.012302.160705 · Cited by 3,158
Quorum-sensing in Gram-negative bacteria
Whitehead, N. (2001) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(01)00059-6 · Cited by 1,607
Bacterial Quorum Sensing in Pathogenic Relationships
de Kievit, T. R., & Iglewski, B. H. (2000) · Infection and Immunity · doi:10.1128/iai.68.9.4839-4849.2000 · Cited by 1,110
Self-citationHentzer, M., Riedel, K., Rasmussen, T. B., Heydorn, A., Andersen, J. B., Parsek, M. R., Rice, S. A., Eberl, L., Molin, S., Høiby, N., et al. (2002) · Microbiology · doi:10.1099/00221287-148-1-87 · Cited by 1,050
Look who's talking: communication and quorum sensing in the bacterial world
Williams, P., Winzer, K., Chan, W. C., & Cámara, M. (2007) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2007.2039 · Cited by 799
Metadata
- Authors
- de Kievit, T., Seed, P. C., Nezezon, J., Passador, L., & Iglewski, B. H.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1999-04
- Volume
- 181
- Issue
- 7
- Pages
- 2175-2184
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W1766151574
- Cited by
- 166
- References
- 1
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- green
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- de Kievit, T., Seed, P. C., Nezezon, J., Passador, L., & Iglewski, B. H. (1999). RsaL, a Novel Repressor of Virulence Gene Expression in Pseudomonas aeruginosa. Journal of Bacteriology. https://doi.org/10.1128/jb.181.7.2175-2184.1999
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