The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Global Carbon Metabolism Regulator Crc Is a Component of a Signal Transduction Pathway Required for Biofilm Development by Pseudomonas aeruginosa
Open accessAbstract
The transition from a planktonic (free-swimming) existence to growth attached to a surface in a biofilm occurs in response to environmental factors, including the availability of nutrients. We show that the catabolite repression control (Crc) protein, which plays a role in the regulation of carbon metabolism, is necessary for biofilm formation in Pseudomonas aeruginosa . Using phase-contrast microscopy, we found that a crc mutant only makes a dispersed monolayer of cells on a plastic surface but does not develop the dense monolayer punctuated by microcolonies typical of the wild-type strain. This is a phenotype identical to that observed in mutants defective in type IV pilus biogenesis. Consistent with this observation, crc mutants are defective in type IV pilus-mediated twitching motility. We show that this defect in type IV pilus function is due (at least in part) to a decrease in pilA (pilin) transcription. We propose that nutritional cues are integrated by Crc as part of a signal transduction pathway that regulates biofilm development.
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Citations
Cites
Bacteria as Multicellular Organisms
Shapiro, J. A. (1988) · Scientific American · doi:10.1038/scientificamerican0688-82 · Cited by 524 · cited 1×
“The products of the asg genes act early in development to sense the appropriate nutritional signals and initiate the formation of fruiting bodies (33).”
Background
Cited by
Biofilm formation as microbial development
O'Toole, G., Kaplan, H. B., & Kolter, R. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.49 · Cited by 3,571
Self-citationPseudomonas aeruginosa Displays Multiple Phenotypes during Development as a Biofilm
Sauer, K., Camper, A. K., Ehrlich, G. D., Costerton, J. W., & Davies, D. G. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.4.1140-1154.2002 · Cited by 1,691
Sambanthamoorthy, K., Sloup, R. E., Parashar, V., Smith, J. M., Kim, E. E., Semmelhack, M. F., Neiditch, M. B., & Waters, C. M. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01396-12 · Cited by 151
Davey, M. E., & Duncan, M. J. (2006) · Journal of Bacteriology · doi:10.1128/jb.01685-05 · Cited by 119
Wu, H., Zeng, M., & Fives-Taylor, P. (2007) · Infection and Immunity · doi:10.1128/iai.01544-06 · Cited by 78
Metadata
- Authors
- O'Toole, G. A., Gibbs, K. A., Hager, P. W., Phibbs, P. V., & Kolter, R.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2000-01-15
- Volume
- 182
- Issue
- 2
- Pages
- 425-431
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2149574330
- Cited by
- 302
- References
- 1
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- green
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- O'Toole, G. A., Gibbs, K. A., Hager, P. W., Phibbs, P. V., & Kolter, R. (2000). The Global Carbon Metabolism Regulator Crc Is a Component of a Signal Transduction Pathway Required for Biofilm Development by Pseudomonas aeruginosa. Journal of Bacteriology. https://doi.org/10.1128/jb.182.2.425-431.2000
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
