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VpsR, a Member of the Response Regulators of the Two-Component Regulatory Systems, Is Required for Expression of vps Biosynthesis Genes and EPS ETr -Associated Phenotypes in Vibrio cholerae O1 El Tor
Open accessAbstract
The rugose colonial variant of Vibrio cholerae O1 El Tor produces an exopolysaccharide (EPS ETr ) that enables the organism to form a biofilm and to resist oxidative stress and the bactericidal action of chlorine. Transposon mutagenesis of the rugose variant led to the identification of vpsR , which codes for a homologue of the NtrC subclass of response regulators. Targeted disruption of vpsR in the rugose colony genetic background yielded a nonreverting smooth-colony morphotype that produced no detectable EPS ETr and did not form an architecturally mature biofilm. Analysis of two genes, vpsA and vpsL , within the vps cluster of EPS ETr biosynthesis genes revealed that their expression is induced above basal levels in the rugose variant, compared to the smooth colonial variant, and requires vpsR . These results show that VpsR functions as a positive regulator of vpsA and vpsL and thus acts to positively regulate EPS ETr production and biofilm formation.
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Cites
The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
Davies, D. G., Parsek, M. R., Pearson, J. P., Iglewski, B. H., Costerton, J. W., & Greenberg, E. P. (1998) · Science · doi:10.1126/science.280.5361.295 · Cited by 3,396
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Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms
Karatan, E., & Watnick, P. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00041-08 · Cited by 1,048
Genetic analysis of Salmonella enteritidis biofilm formation: critical role of cellulose
Solano, C., García, B., Valle, J., Berasain, C., Ghigo, J., Gamazo, C., & Lasa, I. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02802.x · Cited by 554
Roles of Cyclic Diguanylate in the Regulation of Bacterial Pathogenesis
Tamayo, R., Pratt, J. T., & Camilli, A. (2007) · Annual Review of Microbiology · doi:10.1146/annurev.micro.61.080706.093426 · Cited by 486
Waters, C. M., Lu, W., Rabinowitz, J. D., & Bassler, B. L. (2008) · Journal of Bacteriology · doi:10.1128/jb.01756-07 · Cited by 425
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Dickschat, J. S. (2010) · Natural Product Reports · doi:10.1039/b804469b · Cited by 355
Metadata
- Authors
- Yildiz, F. H., Dolganov, N. A., & Schoolnik, G. K.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2001-03
- Volume
- 183
- Issue
- 5
- Pages
- 1716-1726
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2117664645
- Cited by
- 229
- References
- 1
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: VpsR, a Member of the Response Regulators of the Two-Component Regulatory Systems, Is Required for Expression of vps Biosynthesis Genes and EPS ETr -Associated Phenotypes in Vibrio cholerae O1 El Tor. https://app.cochat.ai/papers/10.1128/jb.183.5.1716-1726.2001
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- Yildiz, F. H., Dolganov, N. A., & Schoolnik, G. K. (2001). VpsR, a Member of the Response Regulators of the Two-Component Regulatory Systems, Is Required for Expression of vps Biosynthesis Genes and EPS ETr -Associated Phenotypes in Vibrio cholerae O1 El Tor. Journal of Bacteriology. https://doi.org/10.1128/jb.183.5.1716-1726.2001
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