The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Bap, a Staphylococcus aureus Surface Protein Involved in Biofilm Formation
Open accessAbstract
Identification of new genes involved in biofilm formation is needed to understand the molecular basis of strain variation and the pathogenic mechanisms implicated in chronic staphylococcal infections. A biofilm-producing Staphylococcus aureus isolate was used to generate biofilm-negative transposon (Tn917) insertion mutants. Two mutants were found with a significant decrease in attachment to inert surfaces (early adherence), intercellular adhesion, and biofilm formation. The transposon was inserted at the same locus in both mutants. This locus ( bap [for biofilm associated protein]) encodes a novel cell wall associated protein of 2,276 amino acids (Bap), which shows global organizational similarities to surface proteins of gram-negative ( Pseudomonas aeruginosa and Salmonella enterica serovar Typhi) and gram-positive ( Enteroccocus faecalis ) microorganisms. Bap's core region represents 52% of the protein and consists of 13 successive nearly identical repeats, each containing 86 amino acids. bap was present in a small fraction of bovine mastitis isolates (5% of the 350 S. aureus isolates tested), but it was absent from the 75 clinical human S. aureus isolates analyzed. All staphylococcal isolates harboring bap were highly adherent and strong biofilm producers. In a mouse infection model bap was involved in pathogenesis, causing a persistent infection.
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Cites
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302
Bacterial Biofilms: A Common Cause of Persistent Infections
Costerton, J. W., Stewart, P. S., & Greenberg, E. P. (1999) · Science · doi:10.1126/science.284.5418.1318 · Cited by 12,167
Heilmann, C., Hussain, M., Peters, G., & Götz, F. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.4101774.x · Cited by 700
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Hobley, L., Harkins, C., MacPhee, C. E., & Stanley-Wall, N. R. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv015 · Cited by 581
“…that have been demonstrated to be of importance during in vitro and in vivo biofilm development include the biofilm-associated protein (Bap) (Cucarella et al. 2001), the fibronectin-binding proteins A/B (FnbpA/B) (O’Neill et al. 2008; Geoghegan et al. 2013), clumping factor B (ClfB)…”
BackgroundIzano, E. A., Amarante, M. A., Kher, W. B., & Kaplan, J. B. (2008) · Applied and Environmental Microbiology · doi:10.1128/aem.02073-07 · Cited by 553
Fiore, E., Van Tyne, D., & Gilmore, M. S. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0053-2018 · Cited by 503
Methicillin resistance and the biofilm phenotype in Staphylococcus aureus
McCarthy, H., Rudkin, J. K., Black, N. S., Gallagher, L., O'Neill, E., & O'Gara, J. P. (2015) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2015.00001 · Cited by 426
Role of Biofilm-Associated Protein Bap in the Pathogenesis of Bovine Staphylococcus aureus
Cucarella, C., Tormo, M. A., Úbeda, C., Trotonda, M. P., Monzón, M., Peris, C., Amorena, B., Lasa, I., & Penadés, J. R. (2004) · Infection and Immunity · doi:10.1128/iai.72.4.2177-2185.2004 · Cited by 369
Self-citation
Metadata
- Authors
- Cucarella, C., Solano, C., Valle, J., Amorena, B., Lasa, I., & Penadés, J. R.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2001-05
- Volume
- 183
- Issue
- 9
- Pages
- 2888-2896
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2062128984
- Cited by
- 861
- References
- 3
- FWCI
- 13.33
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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