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Global Stage-Specific Gene Regulation during the Developmental Cycle of Chlamydia trachomatis
Open accessAbstract
Distinct morphological changes associated with the complex development cycle of the obligate intracellular bacterial pathogen Chlamydia trachomatis have been historically well characterized by microscopy. A number of temporally regulated genes have been characterized previously, suggesting that the chlamydial developmental cycle is regulated at the transcriptional level. This hypothesis was tested by microarray analysis in which the entire C. trachomatis genome was analyzed, providing a comprehensive assessment of global gene regulation throughout the chlamydial developmental cycle. Seven temporally cohesive gene clusters were identified, with 22% (189 genes) of the genome differentially expressed during the developmental cycle. The correlation of these gene clusters with hallmark morphological events of the chlamydial developmental cycle suggests three global stage-specific networks of gene regulation.
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Cited by
The chlamydial developmental cycle: Figure 1
AbdelRahman, Y. M., & Belland, R. J. (2005) · FEMS Microbiology Reviews · doi:10.1016/j.femsre.2005.03.002 · Cited by 631
Mechanisms of host cell exit by the intracellular bacterium Chlamydia
Hybiske, K., & Stephens, R. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703218104 · Cited by 489
Self-citationChlamydia pneumoniae — an infectious risk factor for atherosclerosis?
Campbell, L. A., & Kuo, C.-C. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro796 · Cited by 277
Metadata
- Authors
- Nicholson, T. L., Olinger, L., Chong, K., Schoolnik, G., & Stephens, R. S.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2003-05-15
- Volume
- 185
- Issue
- 10
- Pages
- 3179-3189
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2170331865
- Cited by
- 221
- References
- 0
- FWCI
- 15.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Nicholson, T. L., Olinger, L., Chong, K., Schoolnik, G., & Stephens, R. S. (2003). Global Stage-Specific Gene Regulation during the Developmental Cycle of Chlamydia trachomatis. Journal of Bacteriology. https://doi.org/10.1128/jb.185.10.3179-3189.2003
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