The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Long-Term Anaerobic Survival of the Opportunistic Pathogen Pseudomonas aeruginosa via Pyruvate Fermentation
Open accessAbstract
Denitrification and arginine fermentation are central metabolic processes performed by the opportunistic pathogen Pseudomonas aeruginosa during biofilm formation and infection of lungs of patients with cystic fibrosis. Genome-wide searches for additional components of the anaerobic metabolism identified potential genes for pyruvate-metabolizing NADH-dependent lactate dehydrogenase ( ldhA ), phosphotransacetylase ( pta ), and acetate kinase ( ackA ). While pyruvate fermentation alone does not sustain significant anaerobic growth of P. aeruginosa , it provides the bacterium with the metabolic capacity for long-term survival of up to 18 days. Detected conversion of pyruvate to lactate and acetate is dependent on the presence of intact ldhA and ackA-pta loci, respectively. DNA microarray studies in combination with reporter gene fusion analysis and enzyme activity measurements demonstrated the anr - and ihfA- dependent anaerobic induction of the ackA-pta promoter. Potential Anr and integration host factor binding sites were localized. Pyruvate-dependent anaerobic long-term survival was found to be significantly reduced in anr and ihfA mutants. No obvious ldhA regulation by oxygen tension was observed. Pyruvate fermentation is pH dependent. Nitrate respiration abolished pyruvate fermentation, while arginine fermentation occurs independently of pyruvate utilization.
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Metadata
- Authors
- Eschbach, M., Schreiber, K., Trunk, K., Buer, J., Jahn, D., & Schobert, M.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2004-07-15
- Volume
- 186
- Issue
- 14
- Pages
- 4596-4604
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2118343646
- Cited by
- 264
- References
- 41
- FWCI
- 3.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Eschbach, M., Schreiber, K., Trunk, K., Buer, J., Jahn, D., & Schobert, M. (2004). Long-Term Anaerobic Survival of the Opportunistic Pathogen Pseudomonas aeruginosa via Pyruvate Fermentation. Journal of Bacteriology. https://doi.org/10.1128/jb.186.14.4596-4604.2004
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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