The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Comparative Genomics of Staphylococcus aureus Musculoskeletal Isolates
Open accessAbstract
Much of the research aimed at defining the pathogenesis of Staphylococcus aureus has been done with a limited number of strains, most notably the 8325-4 derivative RN6390. Several lines of evidence indicate that this strain is unique by comparison to clinical isolates of S. aureus. Based on this, we have focused our efforts on two clinical isolates (UAMS-1 and UAMS-601), both of which are hypervirulent in our animal models of musculoskeletal infection. In this study, we used comparative genomic hybridization to assess the genome content of these two isolates relative to RN6390 and each of seven sequenced S. aureus isolates. Our comparisons were done by using an amplicon-based microarray from the Pathogen Functional Genomics Resource Center and an Affymetrix GeneChip that collectively represent the genomes of all seven sequenced strains. Our results confirmed that UAMS-1 and UAMS-601 share specific attributes that distinguish them from RN6390. Potentially important differences included the presence of cna and the absence of isaB, sarT, sarU, and sasG in the UAMS isolates. Among the sequenced strains, the UAMS isolates were most closely related to the dominant European clone EMRSA-16. In contrast, RN6390, NCTC 8325, and COL formed a distinct cluster that, by comparison to the other four sequenced strains (Mu50, N315, MW2, and SANGER-476), was the most distantly related to the UAMS isolates and EMRSA-16.
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“of the virulence factors surveyed for this study, only PVL is present in the strain that expressed high virulence following influenza, NRS-193, but is absent in the strains that did not, ATCC 27733 (Table 1) and UAMS-1 [49].”
From Influenza virus primes mice for pneumonia from Staphylococcus aureus. (2011) · cites this paper as [49]
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Lindsay, J. A. (2012) · Humana Press eBooks · doi:10.1007/978-1-62703-185-1_23 · Cited by 1
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McCarthy, H. (2015) · Arrow@dit (Dublin Institute of Technology) · doi:10.13025/16886 · Cited by 1
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Robison, T. M. (2011) · Digital Commons - University of South Florida (University of South Florida)
The role of msa in the global regulation of virulence in Staphylococcus aureus
Nagarajan, V. (2008)
McBride, J. (2006) · ScholarWorks @ The University of New Orleans (The University of New Orleans)
Characterisation of lipoproteins in staphylococcus aureus
Elgallali, A. (2016) · University of Salford Institutional Repository (University of Salford)
Current awareness on comparative and functional genomics
(2005) · Comparative and Functional Genomics · doi:10.1002/cfg.490
Campbell, M. J., Beenken, K. E., Ramírez, A. M., & Smeltzer, M. S. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.07.515558
Cancino-Diaz, M. E., Gómez‐Chávez, F., & Cancino‐Díaz, J. C. (2024) · Indian Journal of Microbiology · doi:10.1007/s12088-024-01339-x
Metadata
- Authors
- Cassat, J. E., Dunman, P. M., McAleese, F., Murphy, E., Projan, S. J., & Smeltzer, M. S.
- Affiliations
- University of Arkansas for Medical Sciences (US)
- Wyeth (US)
- Wyeth Research, Cambridge, Massachusetts
- Corresponding author
- Smeltzer, Mark S.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2005-01-15
- Volume
- 187
- Issue
- 2
- Pages
- 576-592
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- PMC
- PMC543526
- OpenAlex
- W2061688904
- Cited by
- 112
- References
- 70
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 7 · 2015: 8 · 2014: 5 · 2013: 4 · 2012: 8
- FWCI
- 7.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Bacteriology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI043356)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Health Sciences › Medicine › Infectious Diseases › Streptococcal Infections and Treatments
- Health Sciences › Medicine › Surgery › Orthopedic Infections and Treatments
- Keywords
- Staphylococcus aureus, bone and joint infections, comparative genomics, EMRSA-16, SART, strain phylogeny, virulence genes
- MeSH terms
- Antigens, Bacterial, Bacterial Proteins, DNA-Binding Proteins, DNA, Bacterial, Genes, Bacterial, Nucleic Acid Hybridization, Phylogeny, Repressor Proteins, Staphylococcal Infections, Staphylococcus aureus, Genome, Bacterial, Muscle, Skeletal, Adhesins, Bacterial, Genomics
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