The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
β-Lactam Antibiotics Induce the SOS Response and Horizontal Transfer of Virulence Factors in Staphylococcus aureus
Open accessAbstract
Antibiotics that interfere with DNA replication and cell viability activate the SOS response. In Staphylococcus aureus, the antibiotic-induced SOS response promotes replication and high-frequency horizontal transfer of pathogenicity island-encoded virulence factors. Here we report that β-lactams induce a bona fide SOS response in S. aureus, characterized by the activation of the RecA and LexA proteins, the two master regulators of the SOS response. Moreover, we show that β-lactams are capable of triggering staphylococcal prophage induction in S. aureus lysogens. Consequently, and as previously described for SOS induction by commonly used fluoroquinolone antibiotics, β-lactam-mediated phage induction also resulted in replication and high-frequency transfer of the staphylococcal pathogenicity islands, showing that such antibiotics may have the unintended consequence of promoting the spread of bacterial virulence factors.
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Citations
Cites
SOS response promotes horizontal dissemination of antibiotic resistance genes
Beaber, J. W., Hochhut, B., & Waldor, M. K. (2004) · Nature · doi:10.1038/nature02241 · Cited by 1,186
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Environmental factors influencing the development and spread of antibiotic resistance
Bengtsson-Palme, J., Kristiansson, E., & Larsson, D. G. J. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux053 · Cited by 1,167
The Gut Microbiota in the Pathogenesis and Therapeutics of Inflammatory Bowel Disease
Zuo, T., & Ng, S. C. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02247 · Cited by 587
Lu, J., Wang, Y., Jin, M., Yuan, Z., Bond, P., & Guo, J. (2020) · Water Research · doi:10.1016/j.watres.2019.115229 · Cited by 380
Complete and SOS-Mediated Response of Staphylococcus aureus to the Antibiotic Ciprofloxacin
Cirz, R. T., Jones, M. B., Gingles, N. A., Minogue, T. D., Jarrahi, B., Peterson, S. N., & Romesberg, F. E. (2007) · Journal of Bacteriology · doi:10.1128/jb.01464-06 · Cited by 273
Metadata
- Authors
- Maiques, E., Úbeda, C., Campoy, S., Salvador, N., Lasa, I., Novick, R. P., Barbé, J., & Penadés, J. R.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2006-04
- Volume
- 188
- Issue
- 7
- Pages
- 2726-2729
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2130764575
- Cited by
- 365
- References
- 1
- FWCI
- 9.18
- Type
- journal article
- Language
- en
- Open access
- green
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