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Cited by 190

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Reemergence of Enterovirus 71 in 2008 in Taiwan: Dynamics of Genetic and Antigenic Evolution from 1998 to 2008

Open access
Huang, Sheng-Wen, Hsu, Yun-Wei, Smith, Derek J., Kiang, David, Tsai, Huey-Pin, Lin, Kuei-Hsiang, Wang, Shih-Min, Liu, Ching-Chung, Su, Ih-Jen, Wang, Jen-Ren·2009·Journal of Clinical Microbiology

Abstract

In recent years, enterovirus 71 (EV71) has been a cause of numerous outbreaks of hand-foot-and-mouth disease, with severe neurological complications in the Asia-Pacific region. The reemergence in Taiwan of EV71 genotype B5 in 2008 resulted in the largest outbreak of EV71 in Taiwan in the past 11 years. Phylogenetic analyses indicated that dominant genotype changes from B to C or C to B occurred at least three times between 1986 and 2008. Furthermore, antigenic cartography of EV71 by using neutralization tests revealed that the reemerging EV71 genotype B5 strains formed a separate cluster which was antigenically distinct from the B4 and C genotypes. Moreover, analyses of full-length genomic sequences of EV71 circulating in Taiwan during this period showed the occurrence of intra- and interserotypic recombination. Therefore, continuous surveillance of EV71 including the monitoring of genetic evolution and antigenic changes is recommended and may contribute to the development of a vaccine for EV71.

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Metadata

Authors
Huang, S.-W., Hsu, Y.-W., Smith, D. J., Kiang, D., Tsai, H.-P., Lin, K.-H., Wang, S.-M., Liu, C.-C., Su, I.-J., & Wang, J.-R.
Venue
Journal of Clinical Microbiology
Published
2009-11
Volume
47
Issue
11
Pages
3653-3662
ISSN
  • 0095-1137 (ISSN-L)
  • 1098-660X
OpenAlex
W2111265624
Cited by
190
References
3
FWCI
11.27
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Reemergence of Enterovirus 71 in 2008 in Taiwan: Dynamics of Genetic and Antigenic Evolution from 1998 to 2008. https://app.cochat.ai/papers/10.1128/jcm.00630-09
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Huang, S.-W., Hsu, Y.-W., Smith, D. J., Kiang, D., Tsai, H.-P., Lin, K.-H., Wang, S.-M., Liu, C.-C., Su, I.-J., & Wang, J.-R. (2009). Reemergence of Enterovirus 71 in 2008 in Taiwan: Dynamics of Genetic and Antigenic Evolution from 1998 to 2008. Journal of Clinical Microbiology. https://doi.org/10.1128/jcm.00630-09

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