Cited by 1,868Influenza Virus Research StudiesEvolution and Genetic DynamicsRespiratory viral infections research

Mapping the Antigenic and Genetic Evolution of Influenza Virus

Smith, Derek J., Lapedes, Alan S., de Jong, Jan C., Bestebroer, Theo M., Rimmelzwaan, Guus F., Osterhaus, Albert D. M. E., Fouchier, Ron A. M.·2004·Science

Abstract

The antigenic evolution of influenza A (H3N2) virus was quantified and visualized from its introduction into humans in 1968 to 2003. Although there was remarkable correspondence between antigenic and genetic evolution, significant differences were observed: Antigenic evolution was more punctuated than genetic evolution, and genetic change sometimes had a disproportionately large antigenic effect. The method readily allows monitoring of antigenic differences among vaccine and circulating strains and thus estimation of the effects of vaccination. Further, this approach offers a route to predicting the relative success of emerging strains, which could be achieved by quantifying the combined effects of population level immune escape and viral fitness on strain evolution.

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Crossref · 10.1126/science.1097211

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  • The magnitude of the differences in neutralization GMTs against the mutant viruses (0.81- to 1.41-fold) was small compared with the greater than four-fold differences in hemagglutination-inhibition titers used to signal a potential need for a strain change in influenza vaccines.

    “hemagglutination-inhibition titers that have been used to signal potential need for a strain change in influenza vaccines 13 .”

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Authors
Smith, D. J., Lapedes, A. S., de Jong, J. C., Bestebroer, T. M., Rimmelzwaan, G. F., Osterhaus, A. D. M. E., & Fouchier, R. A. M.
Affiliations
  • Los Alamos National Laboratory (US)
  • Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.
Corresponding author
  • Smith, Derek J.
  • Lapedes, Alan S.
  • Fouchier, Ron A. M.
Venue
Science
Published
2004-07-16
Volume
305
Issue
5682
Pages
371-376
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1979158913
Cited by
1,868
References
31
Citations by year
2026: 106 · 2025: 116 · 2024: 138 · 2023: 125 · 2022: 100 · 2021: 130 · 2020: 95 · 2019: 82 · 2018: 85 · 2017: 65 · 2016: 98 · 2015: 83 · 2014: 80 · 2013: 90 · 2012: 62
FWCI
24.11
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
Keywords
H3N2, antigenic drift, genetic evolution, antigenic mapping, circulating strains, vaccine impact, immune evasion, viral fitness
MeSH terms
Antigenic Variation, Genes, Viral, Hemagglutination Inhibition Tests, Hemagglutinins, Viral, Humans, Influenza, Human, Molecular Sequence Data, Mutation, Influenza A virus, Seasons, Genetic Variation, Virology, Mutagenesis, Site-Directed, Evolution, Molecular, Amino Acid Substitution, Genetic Drift

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