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Molecular Epidemiology of Genogroup II-Genotype 4 Noroviruses in the United States between 1994 and 2006
Open accessAbstract
Human noroviruses (NoVs) of genogroup II, genotype 4 (GII.4) are the most common strains detected in outbreaks of acute gastroenteritis worldwide. To gain insight into the epidemiology and genetic variation of GII.4 strains, we analyzed 773 NoV outbreaks reported to the CDC from 1994 to 2006. Of these NoV outbreaks, 629 (81.4%) were caused by GII viruses and 342 (44.2%) were caused by GII.4 strains. The proportion of GII.4 outbreaks increased from 5% in 1994 to 85% in 2006, but distinct annual differences were noted, including sharp increases in 1996, 2003, and 2006 each associated with newly emerging GII.4 strains. Sequence analysis of the full-length VP1 gene of GII.4 strains identified in this study and from GenBank segregated these viruses into at least 9 distinct subclusters which had 1.3 to 3.2% amino acid variation between strains in different subclusters. We propose that GII.4 subclusters be defined as having >5% sequence variation between strains. Our data confirm other studies on the rapid emergence and displacement of highly virulent GII.4 strains.
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RNA VIRUS MUTATIONS AND FITNESS FOR SURVIVAL
Domingo, E., & Holland, J. J. (1997) · Annual Review of Microbiology · doi:10.1146/annurev.micro.51.1.151 · Cited by 1,514
Direct measurement of the poliovirus RNA polymerase error frequency in vitro
Ward, C. D., Stokes, M. A., & Flanegan, J. B. (1988) · Journal of Virology · doi:10.1128/jvi.62.2.558-562.1988 · Cited by 118
Cited by
Norovirus Disease in the United States
Hall, A. J., Lopman, B. A., Payne, D. C., Patel, M. M., Gastañaduy, P. A., Vinjé, J., & Parashar, U. D. (2013) · Emerging Infectious Diseases · doi:10.3201/eid1908.130465 · Cited by 585
Proposal for a unified norovirus nomenclature and genotyping
Kroneman, A., Vega, E., Vennema, H., Vinjé, J., White, P. A., Hansman, G., Green, K., Martella, V., Katayama, K., & Koopmans, M. (2013) · Archives of Virology · doi:10.1007/s00705-013-1708-5 · Cited by 573
Bányai, K., Estes, M. K., Martella, V., & Parashar, U. D. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31128-0 · Cited by 445
Metadata
- Authors
- Zheng, D.-P., Widdowson, M.-A., Glass, R. I., & Vinjé, J.
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2010-01
- Volume
- 48
- Issue
- 1
- Pages
- 168-177
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- OpenAlex
- W2129029652
- Cited by
- 192
- References
- 2
- FWCI
- 10.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Zheng, D.-P., Widdowson, M.-A., Glass, R. I., & Vinjé, J. (2010). Molecular Epidemiology of Genogroup II-Genotype 4 Noroviruses in the United States between 1994 and 2006. Journal of Clinical Microbiology. https://doi.org/10.1128/jcm.01622-09
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