Gender Differences in Inflammatory Processes Could Explain Poorer Prognosis for Males
Open accessAbstract
In their recent paper on the resurgence in mumps virus infections in Ireland ([2][1]), Carr et al. observed a strong ( P < 10−32) bias for acute mumps virus infection in males compared to females that was independent of vaccination status. The authors extrapolated to natural infections the gender
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There is a well-established sex-related link between severity and vulnerability to chronic (but not acute) inflammatory disorders in disorders such as cystic fibrosis and multiple sclerosis.
“There is a well-established sex-related link between severity and vulnerability to chronic (but not acute) inflammatory disorders in disorders such as cystic fibrosis and multiple sclerosis [8, 18].”
From Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy (2020) · cites this paper as [8]
The main discussion (page unavailable) reports poorer prognosis for females with chronic inflammatory diseases including cystic fibrosis, supporting a sex-related difference in severity. It does not name multiple sclerosis, and it also describes sex-related differences in acute conditions, including greater male vulnerability to shock and acute mumps infection. The claim’s exclusion of acute disorders is therefore not supported. (LLM, conf=0.88)
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- Authors
- Casimir, G. J. A., & Duchateau, J.
- Affiliations
- Université Libre de Bruxelles (BE)
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2011-01
- Volume
- 49
- Issue
- 1
- Pages
- 478-479
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC3020457
- OpenAlex
- W2133330388
- Cited by
- 64
- References
- 12
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 4 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 4 · 2017: 6 · 2016: 1 · 2014: 1 · 2013: 2 · 2012: 1
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Keywords
- gender differences, inflammation, prognosis, sex differences, male patients, inflammatory processes
- MeSH terms
- Animals, Communicable Diseases, Female, Humans, Inflammation, Male, Prognosis, Sex Factors
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