Cited by 64Sex and Gender in HealthcareSepsis Diagnosis and TreatmentInflammation biomarkers and pathways

Gender Differences in Inflammatory Processes Could Explain Poorer Prognosis for Males

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Casimir, Georges J. A., Duchateau, Jean·2011·Journal of Clinical Microbiology

Abstract

In their recent paper on the resurgence in mumps virus infections in Ireland ([2][1]), Carr et al. observed a strong ( P < 10−32) bias for acute mumps virus infection in males compared to females that was independent of vaccination status. The authors extrapolated to natural infections the gender

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Crossref · 10.1128/jcm.02096-10

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  • There is a well-established sex-related link between severity and vulnerability to chronic (but not acute) inflammatory disorders in disorders such as cystic fibrosis and multiple sclerosis.

    “There is a well-established sex-related link between severity and vulnerability to chronic (but not acute) inflammatory disorders in disorders such as cystic fibrosis and multiple sclerosis [8, 18].”

    From Loss of homeostatic microglial phenotype in CSF1R-related Leukoencephalopathy (2020) · cites this paper as [8]

    The main discussion (page unavailable) reports poorer prognosis for females with chronic inflammatory diseases including cystic fibrosis, supporting a sex-related difference in severity. It does not name multiple sclerosis, and it also describes sex-related differences in acute conditions, including greater male vulnerability to shock and acute mumps infection. The claim’s exclusion of acute disorders is therefore not supported. (LLM, conf=0.88)

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Authors
Casimir, G. J. A., & Duchateau, J.
Affiliations
Université Libre de Bruxelles (BE)
Venue
Journal of Clinical Microbiology
Published
2011-01
Volume
49
Issue
1
Pages
478-479
ISSN
  • 0095-1137 (ISSN-L)
  • 1098-660X
OpenAlex
W2133330388
Cited by
64
References
12
Citations by year
2026: 4 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 4 · 2021: 8 · 2020: 7 · 2019: 8 · 2018: 4 · 2017: 6 · 2016: 1 · 2014: 1 · 2013: 2 · 2012: 1
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Microbiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
  • Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords
gender differences, inflammation, prognosis, sex differences, male patients, inflammatory processes
MeSH terms
Animals, Communicable Diseases, Female, Humans, Inflammation, Male, Prognosis, Sex Factors

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