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Merthiolate treatment of pathogenic fungi
Open accessAbstract
The action of Merthiolate on the pathogenic yeasts Blastomyces, dermatitidis, Histoplasma capsulatum, and Sporothrix schenckii was compared to the effect of treatment with formaldehyde. Concentrations of 1:10,000 and 1:5,000 Merthiolate for three exposure times (24, 48, and 72 h) at 4 and 25 degrees C were tested on three media (brain heart infusion with and without blood, and modified Sabouraud agar). The effect of Merthiolate on these three yeasts was primarily fungistatic, with maximum effect using 1:5,000 Merthiolate at 25 degrees C for at least 48 h. Mycelial suspensions of B. dermatitidis, H. capsulatum, S. shenckii, and the yeast phase of Cryptococcus neoformans were susceptible to the 1:5,000 Merthiolate concentration after 24 h of treatment. The antifungal effect of Methiolate varies with species and growth phase of the fungus. Concentration, time of exposure, and temperature of incubation are important variables.
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“This method of killing was used to minimize changes in the cell wall [52].”
From Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells (2007) · cites this paper as [52]
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Citations
Cited by
Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells
Phan, Q. T., Myers, C. L., Fu, Y., Sheppard, D. C., Yeaman, M. R., Welch, W. H., Ibrahim, A. S., Edwards, J. E., & Filler, S. G. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050064 · Cited by 641
“This method of killing was used to minimize changes in the cell wall [52].”
MethodPark, H., Myers, C. L., Sheppard, D. C., Phan, Q. T., Sanchez, A. A., E. Edwards, J., & Filler, S. G. (2004) · Cellular Microbiology · doi:10.1111/j.1462-5822.2004.00476.x · Cited by 207
“The metabolic poison, thimerosal, was used to avoid denaturation of candidal surface proteins and maintain cellular integrity (Deighton et al., 1979).”
MethodBertuzzi, M., Schrettl, M., Alcazar-Fuoli, L., Cairns, T. C., Muñoz, A., Walker, L. A., Herbst, S., Safari, M., Cheverton, A. M., Chen, D., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004413 · Cited by 158
“02% thimerosal (Sigma) overnight at 4uC [71], a treatment which preserves cellular integrity.”
BackgroundLopes-Bezerra, L. M., & Filler, S. G. (2003) · Blood · doi:10.1182/blood-2003-06-2186 · Cited by 120
Sulphate metabolism of selenate-resistant Schizosaccharomyces pombe mutants.
Bánszky, L., Simonics, T., & Maráz, A. (2003) · Journal of General and Applied Microbiology · doi:10.2323/jgam.49.271 · Cited by 21
Safety considerations in handling exoantigen extracts from pathogenic fungi
Standard, P., & Kaufman, L. (1982) · Journal of Clinical Microbiology · doi:10.1128/jcm.15.4.663-667.1982 · Cited by 15
Antifungal synergism. A proposed dosage for corneal storage medium.
Kowalski, R., Sundar-Raj, C. V., Stuart, J. C., & Dunn, D. S. (1985) · A M A Archives of Ophthalmology · doi:10.1001/archopht.1985.01050020102030 · Cited by 9
Exoantigen tests for the immunoidentification of fungal cultures
Kaufman, L., Standard, P., & Padhye, A. (1983) · Mycopathologia · doi:10.1007/bf00436938 · Cited by 9
Sekhon, A., Disalvo, A., Standard, P., Kaufman, L., Terreni, A., & Garg, A. (1984) · American Journal of Clinical Pathology · doi:10.1093/ajcp/82.2.206 · Cited by 8
Identification of mycotic pathogens using antisera to exoantigens
Disalvo, A. (1985) · doi:10.1016/s0197-1859(85)80081-9 · Cited by 3
Bactericidal and fungicidal activity of Mirsky's tissue fixative
Perryman, F., Flournoy, D., & Qadri, S. M. H. (1983) · doi:10.1016/0196-6553(83)90102-5
Metadata
- Authors
- Deighton, F. J., Hall, N. K., & Larsh, H. W.
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 1979-08
- Volume
- 10
- Issue
- 2
- Pages
- 144-146
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC273118
- OpenAlex
- W1775936931
- Cited by
- 11
- References
- 0
- Citations by year
- 2014: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
- Keywords
- thimerosal, antifungal agents, pathogenic yeasts, Blastomyces dermatitidis, Histoplasma capsulatum, Sporothrix schenckii, Cryptococcus neoformans, formaldehyde, fungistatic activity, temperature dependence, incubation time, fungal growth phase
- MeSH terms
- Blastomyces, Cryptococcus, Cryptococcus neoformans, Ethylmercury Compounds, Histoplasma, Sporothrix, Temperature, Thimerosal
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