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Serum and nasal wash antibodies associated with resistance to experimental challenge with influenza A wild-type virus
Open accessAbstract
To identify immunological predictors of resistance to influenza A infection and illness, the immunological status of live and inactivated virus vaccines subsequently challenged with H1N1 or H3N2 wild-type virus was examined. We refer to prechallenge antibodies of vaccinees receiving live attenuated virus as infection induced and those receiving inactivated virus as inactivated vaccine induced. Inactivated vaccine-induced protection against wild-type virus infection or illness correlated with the level of neuraminidase-inhibiting antibody in serum, local hemagglutinin immunoglobulin G (IgG) (but not IgA) enzyme-linked immunosorbent assay antibody, and hemagglutination-inhibiting antibody in serum. In contrast, infection-induced resistance to wild-type virus infection correlated with local hemagglutinin IgA antibody and neuraminidase-inhibiting antibody in serum, but not with hemagglutination-inhibiting antibody in serum. These observations suggest that live vaccine virus infection-induced and inactivated vaccine-induced immunity may involve different compartments of the immune system; sufficient antibody in either serum or nasal secretions is capable of conferring resistance.
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Cited by
Grohskopf, L. A., Sokolow, L. Z., Broder, K. R., Walter, E. B., Fry, A. M., & Jernigan, D. B. (2018) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr6703a1 · Cited by 1,632
Grohskopf, L. A., Sokolow, L. Z., Broder, K. R., Olsen, S. J., Karron, R. A., Jernigan, D. B., & Bresee, J. S. (2016) · MMWR. Recommendations and Reports · doi:10.15585/mmwr.rr6505a1 · Cited by 593
Mechanisms of GII.4 Norovirus Persistence in Human Populations
Lindesmith, L. C., Donaldson, E. F., LoBue, A. D., Cannon, J. L., Zheng, D.-P., Vinje, J., & Baric, R. S. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050031 · Cited by 573
Cox, R. J., Brokstad, K. A., & Ogra, P. (2004) · Scandinavian Journal of Immunology · doi:10.1111/j.0300-9475.2004.01382.x · Cited by 553
INTERACTION OF ANTIGENS AND ANTIBODIES AT MUCOSAL SURFACES
Lamm, M. E. (1997) · Annual Review of Microbiology · doi:10.1146/annurev.micro.51.1.311 · Cited by 429
Metadata
- Authors
- Clements, M. L., Betts, R. F., Tierney, E. L., & Murphy, B. R.
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 1986-07
- Volume
- 24
- Issue
- 1
- Pages
- 157-160
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- OpenAlex
- W1618733816
- Cited by
- 435
- References
- 0
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Clements, M. L., Betts, R. F., Tierney, E. L., & Murphy, B. R. (1986). Serum and nasal wash antibodies associated with resistance to experimental challenge with influenza A wild-type virus. Journal of Clinical Microbiology. https://doi.org/10.1128/jcm.24.1.157-160.1986
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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