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Rapid diagnosis of pulmonary tuberculosis by using Roche AMPLICOR Mycobacterium tuberculosis PCR test

Open access
D'Amato, R F, Wallman, A A, Hochstein, L H, Colaninno, P M, Scardamaglia, M, Ardila, E, Ghouri, M, Kim, K, Patel, R C, Miller, A·1995·Journal of Clinical Microbiology

Abstract

A rapid PCR-based test for the diagnosis of pulmonary tuberculosis, the Roche AMPLICOR Mycobacterium tuberculosis test (AMPLICOR MTB), was evaluated. Results from AMPLICOR MTB were compared with culture results and the final clinical diagnosis for each patient. A total of 985 specimens from 372 patients were tested. When AMPLICOR MTB results were compared with resolved results, i.e., a specimen grew M. tuberculosis or was obtained from a patient with a clinical diagnosis of tuberculosis, the sensitivity, specificity, positive predictive value, and negative predictive value for the AMPLICOR MTB test were 66.7, 99.6, 91.7, and 97.7%, respectively. These results were comparable to those obtained from culture. Test results were available approximately 6.5 h after specimen receipt in the laboratory. Our data demonstrate that AMPLICOR MTB will provide rapid, valuable information for the diagnosis and control of tuberculosis.

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Crossref · 10.1128/jcm.33.7.1832-1834.1995

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Metadata

Authors
D'Amato, R. F., Wallman, A. A., Hochstein, L. H., Colaninno, P. M., Scardamaglia, M., Ardila, E., Ghouri, M., Kim, K., Patel, R. C., & Miller, A.
Venue
Journal of Clinical Microbiology
Published
1995-07
Volume
33
Issue
7
Pages
1832-1834
ISSN
  • 0095-1137 (ISSN-L)
  • 1098-660X
OpenAlex
W2147391451
Cited by
158
References
2
FWCI
18.21
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Rapid diagnosis of pulmonary tuberculosis by using Roche AMPLICOR Mycobacterium tuberculosis PCR test. https://app.cochat.ai/papers/10.1128/jcm.33.7.1832-1834.1995
The paper
D'Amato, R. F., Wallman, A. A., Hochstein, L. H., Colaninno, P. M., Scardamaglia, M., Ardila, E., Ghouri, M., Kim, K., Patel, R. C., & Miller, A. (1995). Rapid diagnosis of pulmonary tuberculosis by using Roche AMPLICOR Mycobacterium tuberculosis PCR test. Journal of Clinical Microbiology. https://doi.org/10.1128/jcm.33.7.1832-1834.1995

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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