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Occurrence of Leishmania infantum Parasitemia in Asymptomatic Blood Donors Living in an Area of Endemicity in Southern France
Open accessAbstract
Visceral leishmaniosis (VL) due to Leishmania infantum(L. chagasi) is a lethal disease if untreated, but asymptomatic L. infantum infections have been reported previously. A better understanding of parasite transmission, dissemination, and survival in the human host is needed. The purpose of this study was to assess whether L. infantum circulated in peripheral blood of subjects with no history of VL. Sera from 565 blood donors were screened by Western blotting to detect Leishmania-specific antibodies and identify individuals with probable past exposure to Leishmania. Seropositivity was found in 76 donors whose buffy coats were examined by PCR and direct culture. The parasite minicircle kinetoplast DNA was amplified from blood samples of nine donors. Promastigotes were detected by culture in blood samples from nine donors. Only two donors were PCR and culture positive. These results indicate that L. infantum circulates intermittently and at low density in the blood of healthy seropositive individuals, who thus appear to be asymptomatic carriers. Implications for the safety of blood transfusion are discussed.
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Citations
Cited by
Leishmaniasis Worldwide and Global Estimates of Its Incidence
Alvar, J., Vélez, I. D., Bern, C., Herrero, M., Desjeux, P., Cano, J., Jannin, J., Boer, M. D., & the WHO Leishmaniasis Control Team (2012) · PLoS ONE · doi:10.1371/journal.pone.0035671 · Cited by 5,141
Murray, H. W., Berman, J. D., Davies, C. R., & Saravia, N. G. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67629-5 · Cited by 1,771
Tolerance to trypanosomatids: a threat, or a key for disease elimination?
Berthier, D., Brenière, S. F., Bras-Gonçalves, R., Lemesre, J.-L., Jamonneau, V., Solano, P., Lejon, V., Thévenon, S., & Bucheton, B. (2016) · Trends in Parasitology · doi:10.1016/j.pt.2015.11.001 · Cited by 65
Metadata
- Authors
- le Fichoux, Y., Quaranta, J.-F., Aufeuvre, J.-P., Lelievre, A., Marty, P., Suffia, I., Rousseau, D., & Kubar, J.
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 1999-06
- Volume
- 37
- Issue
- 6
- Pages
- 1953-1957
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- OpenAlex
- W2106378467
- Cited by
- 315
- References
- 0
- FWCI
- 8.22
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Occurrence of Leishmania infantum Parasitemia in Asymptomatic Blood Donors Living in an Area of Endemicity in Southern France. https://app.cochat.ai/papers/10.1128/jcm.37.6.1953-1957.1999
- The paper
- le Fichoux, Y., Quaranta, J.-F., Aufeuvre, J.-P., Lelievre, A., Marty, P., Suffia, I., Rousseau, D., & Kubar, J. (1999). Occurrence of Leishmania infantum Parasitemia in Asymptomatic Blood Donors Living in an Area of Endemicity in Southern France. Journal of Clinical Microbiology. https://doi.org/10.1128/jcm.37.6.1953-1957.1999
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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