Tolerance to trypanosomatids: a threat, or a key for disease elimination?
Abstract
So far, research on trypanosomatid infections has been driven by 'disease by disease' approaches, leading to different concepts and control strategies. It is, however, increasingly clear that they share common features such as the ability to generate long-lasting asymptomatic infections in their mammalian hosts. Trypanotolerance, long integrated in animal African trypanosomiasis control, historically refers to the ability of cattle breeds to limit Trypanosoma infection and pathology, but has only recently been recognized in humans. Whilst trypanotolerance is absent from the vocabulary on leishmaniasis and Chagas disease, asymptomatic infections also occur. We review the concept of trypanotolerance across the trypanosomatids and discuss the importance of asymptomatic carriage in the current context of elimination.
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Trypanotolerant N'Dama do better control anemia, a process mediated by hematopoietic cell differentiation, than trypanosusceptible breeds.
“In agreement with our findings, it has been reported by several studies that trypanotolerant N’Dama do better control anemia, a process mediated by hematopoietic cells differentiation, than trypanosusceptible breeds (Berthier et al., 2016; Naessens, 2006).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Berthier et al., 2016
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Self-citationSerial analysis of gene expression (SAGE) in bovine trypanotolerance: preliminary results
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Self-citationTrypanotolerance : an individual not a breed character
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IL2RA Genetic Variants Reduce IL-2–Dependent Responses and Aggravate Human Cutaneous Leishmaniasis
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Self-citationPopulation parameters for traits defining trypanotolerance in an F2 cross of N’Dama and Boran cattle
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BackgroundInfluentialAssessing Strategies Against Gambiense Sleeping Sickness Through Mathematical Modeling
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Peptide-based vaccine successfully induces protective immunity against canine visceral leishmaniasis
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Self-citationSearch for Selection Signatures Related to Trypanosomosis Tolerance in African Goats
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Self-citationReet, N. V., Pyana, P. P., Dehou, S., Bebronne, N., Deborggraeve, S., & Büscher, P. (2021) · PLoS ONE · doi:10.1371/journal.pone.0258711 · Cited by 17 · see citing works
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Self-citationSelection Increases Mitonuclear DNA Discordance but Reconciles Incompatibility in African Cattle
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Goat Science - From Keeping to Precision Production
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Kaboré, J., Camara, O., Koffi, M., Sanou, D., Ilboudo, H., Sakandé, H., Camara, M., Meeûs, T. D., Ravel, S., Bélem, A. M. G., et al. (2018) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2018.05.018 · Cited by 10 · see citing works
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Variation in disease phenotype is marked in equine trypanosomiasis
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Let's get fISSical: fastin silicosynchronization as a new tool for cell division cycle analysis
Morriswood, B., & Engstler, M. (2017) · Parasitology · doi:10.1017/s0031182017000038 · Cited by 6 · see citing works
Ribeiro, L. F., de Souza, A. L., Alves, A. L., Rocha, A. R., Borges, A. V. F., dos Reis, K. B., Silva, L. C. D. S. E., de Oliveira, L. C., Magalhães, L. A., Gonçalves, M. L. D. O., et al. (2019) · PubVet · doi:10.31533/pubvet.v13n10a437.1-5 · Cited by 6 · see citing works
Evolving anti-disease strategies from biochemical pathogenesis of african trypanosomiasis
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Tripanossomose bovina: Revisão
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Capewell, P., Ilboudo, H., Cooper, A., Kaboré, J. W., Noyes, H. A., Neill, K. O., Camara, M., Jamonneau, V., MacLeod, A., & Bucheton, B. (2024) · medRxiv · doi:10.1101/2024.05.07.24306988 · Cited by 2 · see citing works
Self-citationTripanossomose bovina no Brasil
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Adoption of Genomics and Breeding Strategies to Improve Goat Productivity in Southern Africa
Monau, P. I., Raphaka, K., & Nsoso, S. J. (2022) · Springer eBooks · doi:10.1007/978-3-031-09614-3_21
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Vanvanhossou, S. F. U., Scheper, C., Dossa, L. H., Yin, T., Brügemann, K., & König, S. (2020) · Figshare · doi:10.6084/m9.figshare.13226188
Additional file 8 of Variation in disease phenotype is marked in equine trypanosomiasis
Raftery, A. G., Jallow, S., Coultous, R., Rodgers, J., & Sutton, D. G. M. (2020) · Figshare · doi:10.6084/m9.figshare.12016587
Additional file 1 of Variation in disease phenotype is marked in equine trypanosomiasis
Raftery, A. G., Jallow, S., Coultous, R., Rodgers, J., & Sutton, D. G. M. (2020) · Figshare · doi:10.6084/m9.figshare.12016551
Vanvanhossou, S. F. U., Scheper, C., Dossa, L. H., Yin, T., Brügemann, K., & König, S. (2020) · Figshare · doi:10.6084/m9.figshare.13226191
Vanvanhossou, S. F. U., Scheper, C., Dossa, L. H., Yin, T., Brügemann, K., & König, S. (2020) · Figshare · doi:10.6084/m9.figshare.13226182
Additional file 5 of Variation in disease phenotype is marked in equine trypanosomiasis
Raftery, A. G., Jallow, S., Coultous, R., Rodgers, J., & Sutton, D. G. M. (2020) · Figshare · doi:10.6084/m9.figshare.12016572
Vanvanhossou, S. F. U., Scheper, C., Dossa, L. H., Yin, T., Brügemann, K., & König, S. (2020) · Figshare · doi:10.6084/m9.figshare.13226197
Vanvanhossou, S. F. U., Scheper, C., Dossa, L. H., Yin, T., Brügemann, K., & König, S. (2020) · Figshare · doi:10.6084/m9.figshare.13226194
Additional file 6 of Variation in disease phenotype is marked in equine trypanosomiasis
Raftery, A. G., Jallow, S., Coultous, R., Rodgers, J., & Sutton, D. G. M. (2020) · Figshare · doi:10.6084/m9.figshare.12016581
Additional file 2 of Variation in disease phenotype is marked in equine trypanosomiasis
Raftery, A. G., Jallow, S., Coultous, R., Rodgers, J., & Sutton, D. G. M. (2020) · Figshare · doi:10.6084/m9.figshare.12016554
Additional file 7 of Variation in disease phenotype is marked in equine trypanosomiasis
Raftery, A. G., Jallow, S., Coultous, R., Rodgers, J., & Sutton, D. G. M. (2020) · Figshare · doi:10.6084/m9.figshare.12016584
Additional file 3 of Variation in disease phenotype is marked in equine trypanosomiasis
Raftery, A. G., Jallow, S., Coultous, R., Rodgers, J., & Sutton, D. G. M. (2020) · Figshare · doi:10.6084/m9.figshare.12016560
Additional file 4 of Variation in disease phenotype is marked in equine trypanosomiasis
Raftery, A. G., Jallow, S., Coultous, R., Rodgers, J., & Sutton, D. G. M. (2020) · Figshare · doi:10.6084/m9.figshare.12016566
Genomic diversity, population structure and admixture in native cattle breeds of Benin
Zorobouragui, L., Tapsoba, S. A. R., TRAORE, A., Periasamy, K., Pichler, R., Mavunga, T. K., Séidou, A. A., Worogo, H. S. S., Taba, N., Azalou, M., et al. (2026) · World Congress on Genetics Applied to Livestock Production (WCGALP) · doi:10.31274/wcgalp.24000
- Authors
- Berthier, D., Brenière, S. F., Bras-Gonçalves, R., Lemesre, J.-L., Jamonneau, V., Solano, P., Lejon, V., Thévenon, S., & Bucheton, B.
- Affiliations
- Centre de Coopération Internationale en Recherche Agronomique pour le Développement (FR)
- Institut de Recherche pour le Développement (FR)
- Institut de Recherche pour le Développement (CI)
- Ministry of Health and Public Hygiene (GN)
- Corresponding author
- Solano, Philippe
- ORCID
- Venue
- Trends in Parasitology
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 32
- Issue
- 2
- Pages
- 157-168
- ISSN
- 1471-4922 (ISSN-L)
- OpenAlex
- W2189275857
- Cited by
- 65
- References
- 101
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 20 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 7
- FWCI
- 0.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Parasitology (publishedVersion)
- PubMed (publishedVersion)
- Agritrop (Cirad) (submittedVersion)
- Funders
- Alliance Française contre les Maladies Parasitaires
- Agence Nationale de la Recherche (ANR-11-LABX-0024)
- Topics
- Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Keywords
- trypanotolerance, trypanosomatids, trypanosomes, Chagas disease, leishmaniasis, asymptomatic infection, asymptomatic carriage, disease elimination, cattle breeds, African animal trypanosomosis, host-parasite interactions
- MeSH terms
- Animals, Humans, Immune Tolerance, Leishmaniasis, Trypanosoma, Trypanosomiasis, African, Chagas Disease, Disease Eradication
About these checks
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