Cited by 65Trypanosoma species research and implicationsResearch on Leishmaniasis StudiesVector-borne infectious diseases

Tolerance to trypanosomatids: a threat, or a key for disease elimination?

Berthier, David, Brenière, Simone F., Bras-Gonçalves, Rachel, Lemesre, Jean-Loup, Jamonneau, Vincent, Solano, Philippe, Lejon, Veerle, Thévenon, Sophie +1 more·2016·Trends in Parasitology

Abstract

So far, research on trypanosomatid infections has been driven by 'disease by disease' approaches, leading to different concepts and control strategies. It is, however, increasingly clear that they share common features such as the ability to generate long-lasting asymptomatic infections in their mammalian hosts. Trypanotolerance, long integrated in animal African trypanosomiasis control, historically refers to the ability of cattle breeds to limit Trypanosoma infection and pathology, but has only recently been recognized in humans. Whilst trypanotolerance is absent from the vocabulary on leishmaniasis and Chagas disease, asymptomatic infections also occur. We review the concept of trypanotolerance across the trypanosomatids and discuss the importance of asymptomatic carriage in the current context of elimination.

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Crossref · 10.1016/j.pt.2015.11.001

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  • Trypanotolerant N'Dama do better control anemia, a process mediated by hematopoietic cell differentiation, than trypanosusceptible breeds.

    “In agreement with our findings, it has been reported by several studies that trypanotolerant N’Dama do better control anemia, a process mediated by hematopoietic cells differentiation, than trypanosusceptible breeds (Berthier et al., 2016; Naessens, 2006).”

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Authors
Berthier, D., Brenière, S. F., Bras-Gonçalves, R., Lemesre, J.-L., Jamonneau, V., Solano, P., Lejon, V., Thévenon, S., & Bucheton, B.
Affiliations
  • Centre de Coopération Internationale en Recherche Agronomique pour le Développement (FR)
  • Institut de Recherche pour le Développement (FR)
  • Institut de Recherche pour le Développement (CI)
  • Ministry of Health and Public Hygiene (GN)
Corresponding author
Solano, Philippe
Venue
Trends in Parasitology
Publisher
Elsevier BV
Published
2016-02
Volume
32
Issue
2
Pages
157-168
ISSN
1471-4922 (ISSN-L)
OpenAlex
W2189275857
Cited by
65
References
101
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 20 · 2019: 5 · 2018: 7 · 2017: 5 · 2016: 7
FWCI
0.82
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Parasitology (publishedVersion)
  • PubMed (publishedVersion)
  • Agritrop (Cirad) (submittedVersion)
Funders
  • Alliance Française contre les Maladies Parasitaires
  • Agence Nationale de la Recherche (ANR-11-LABX-0024)
Topics
  • Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
  • Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
Keywords
trypanotolerance, trypanosomatids, trypanosomes, Chagas disease, leishmaniasis, asymptomatic infection, asymptomatic carriage, disease elimination, cattle breeds, African animal trypanosomosis, host-parasite interactions
MeSH terms
Animals, Humans, Immune Tolerance, Leishmaniasis, Trypanosoma, Trypanosomiasis, African, Chagas Disease, Disease Eradication

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