Limited Level of Accuracy Provided by Available Rapid Diagnosis Tests for Malaria Enhances the Need for PCR-Based Reference Laboratories
Open accessAbstract
The rise of imported malaria cases and the high fatality rate in Europe make the search for new and easy diagnostic methods necessary. Rapid diagnosis tests (RDTs) are, in part, developed to cover the lack of diagnosis experience. Unfortunately, our data suggest that the accuracy of RDTs is insufficient and could increase the number of incorrect malaria diagnoses.
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Immunochromatographic assays based on antigen detection are relatively insensitive in cases of low parasitemia.
“Immunochromatographic assays based on antigen detection have been developed but are also relatively insensitive in cases of low parasitemia (22, 24, 30).”
From Real-Time PCR for Detection and Identification of <i>Plasmodium</i> spp (2005) · cites this paper as [30]
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Imported Malaria: Prospective Analysis of Problems in Diagnosis and Management
Kain, K. C., Harrington, M. A., Tennyson, S., & Keystone, J. S. (1998) · Clinical Infectious Diseases · doi:10.1086/514616 · Cited by 371 · see citing works
Usefulness of Seminested Multiplex PCR in Surveillance of Imported Malaria in Spain
Rubio, J. M., Benito, A., Berzosa, P. J., Roche, J., Puente, S., Subirats, M., López‐Vélez, R., García, L., & Alvar, J. (1999) · Journal of Clinical Microbiology · doi:10.1128/jcm.37.10.3260-3264.1999 · Cited by 140 · see citing works
Self-citationCropley, I. M. (2000) · BMJ · doi:10.1136/bmj.321.7259.484 · Cited by 21 · see citing works
Malaria surveillance in Italy: 1997 analysis and 1998 provisional data
Romi, R., Boccolini, D., & Majori, G. (1999) · Eurosurveillance · doi:10.2807/esm.04.07.00064-en · Cited by 10 · see citing works
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Real-Time PCR for Detection and Identification of <i>Plasmodium</i> spp
Mangold, K. A., Manson, R. U., Koay, E. S. C., Stephens, L., Regner, M., Thomson, R. B., Peterson, L. R., & Kaul, K. L. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.5.2435-2440.2005 · Cited by 278 · see citing works
- Authors
- Rubio, J. M., Buhigas, I., Subirats, M., Baquero, M., Puente, S., & Benito, A.
- Affiliations
- Instituto de Salud Carlos III (ES)
- <!--label omitted: 2-->Department of Microbiology2 and
- Carlos III Hospital (ES)
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2001-07
- Volume
- 39
- Issue
- 7
- Pages
- 2736-2737
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC88226
- OpenAlex
- W2118961715
- Cited by
- 82
- References
- 4
- Citations by year
- 2024: 2 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 7 · 2012: 2
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
- Keywords
- malaria, rapid diagnostic tests, diagnostic accuracy, imported malaria
- MeSH terms
- Adolescent, Adult, Aged, Animals, Child, Child, Preschool, Humans, Infant, Laboratories, Malaria, Middle Aged, Plasmodium, Reagent Kits, Diagnostic, Reference Standards, Sensitivity and Specificity, Time Factors, Polymerase Chain Reaction
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