The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Human Herpesvirus 6 Chromosomal Integration in Immunocompetent Patients Results in High Levels of Viral DNA in Blood, Sera, and Hair Follicles
Open accessAbstract
Six immunocompetent patients with human herpesvirus 6 (HHV-6) chromosomal integration had HHV-6 and β-globin DNA quantified in various samples by PCR. The mean HHV-6 DNA concentration (log 10 copies/milliliter) in blood was 7.0 (≥1 HHV-6 DNA copies/leukocyte), and in serum it was 5.3 (≥1 HHV-6 DNA copies/lysed cell). The mean HHV-6 DNA load (log 10 copies)/hair follicle was 4.2 (≥1 copies/hair follicle cell), demonstrating that viral integration is not confined to blood cells. The characteristically high HHV-6 DNA levels in chromosomal integration may confound laboratory diagnosis of HHV-6 infection and should be given due consideration.
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Citations
Cites
Human herpesvirus 6 (HHV6) DNA persistence and reactivation in healthy children
Caserta, M. T., McDermott, M. P., Dewhurst, S., Schnabel, K., Carnahan, J. A., Gilbert, L., Lathan, G., Lofthus, G. K., & Hall, C. B. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.06.016 · Cited by 95
Cited by
Chromosomally integrated human herpesvirus 6: questions and answers
Pellett, P. E., Ablashi, D. V., Ambros, P. F., Agut, H., Caserta, M. T., Descamps, V., Flamand, L., Gautheret‐Dejean, A., Hall, C. B., Kamble, R. T., et al. (2012) · Reviews in Medical Virology · doi:10.1002/rmv.715 · Cited by 377
Self-citationLaboratory and Clinical Aspects of Human Herpesvirus 6 Infections
Agut, H., Bonnafous, P., & Gautheret-Dejean, A. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00122-14 · Cited by 345
Ward, K. N., Leong, H. N., Thiruchelvam, A. D., Atkinson, C. E., & Clark, D. A. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.02115-06 · Cited by 174
Self-citationStudahl, M., Lindquist, L., Eriksson, B.-M., Günther, G., Bengner, M., Franzen-Röhl, E., Fohlman, J., Bergström, T., & Aurelius, E. (2013) · Drugs · doi:10.1007/s40265-013-0007-5 · Cited by 90
Human Herpesviruses 6A, 6B, and 7
Agut, H., Bonnafous, P., & Gautheret-Dejean, A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.dmih2-0007-2015 · Cited by 87
Metadata
- Authors
- Ward, K. N., Leong, H. N., Nacheva, E. P., Howard, J., Atkinson, C. E., Davies, N. W. S., Griffiths, P. D., & Clark, D. A.
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2006-04
- Volume
- 44
- Issue
- 4
- Pages
- 1571-1574
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- OpenAlex
- W2111471104
- Cited by
- 213
- References
- 1
- FWCI
- 12.40
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Ward, K. N., Leong, H. N., Nacheva, E. P., Howard, J., Atkinson, C. E., Davies, N. W. S., Griffiths, P. D., & Clark, D. A. (2006). Human Herpesvirus 6 Chromosomal Integration in Immunocompetent Patients Results in High Levels of Viral DNA in Blood, Sera, and Hair Follicles. Journal of Clinical Microbiology. https://doi.org/10.1128/jcm.44.4.1571-1574.2006
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