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Receptor Usage and Cell Entry of Porcine Epidemic Diarrhea Coronavirus
Open accessAbstract
Porcine epidemic diarrhea coronavirus (PEDV) has significantly damaged America's pork industry. Here we investigate the receptor usage and cell entry of PEDV. PEDV recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptor N -acetylneuraminic acid. Moreover, PEDV infects cells from pig, human, monkey, and bat. These results support the idea of bats as an evolutionary origin for PEDV, implicate PEDV as a potential threat to other species, and suggest antiviral strategies to control its spread.
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Citations
Cited by
Structure, Function, and Evolution of Coronavirus Spike Proteins
Li, F. (2016) · Annual Review of Virology · doi:10.1146/annurev-virology-110615-042301 · Cited by 2,740
Self-citationStructural insights into coronavirus entry
(2019) · Advances in Virus Research · doi:10.1016/bs.aivir.2019.08.002 · Cited by 769
Casagrande, M., Favieri, F., Tambelli, R., & Forte, G. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.05.011 · Cited by 735
Zehr, J. D., Pond, S. L. K., Martin, D. P., Ceres, K., Whittaker, G. R., Millet, J. K., Goodman, L. B., & Stanhope, M. J. (2022) · Viruses · doi:10.3390/v14050853 · Cited by 23
Metadata
- Authors
- Liu, C., Tang, J., Ma, Y., Liang, X., Yang, Y., Peng, G., Qi, Q., Jiang, S., Li, J., Du, L., & Li, F.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2015-06
- Volume
- 89
- Issue
- 11
- Pages
- 6121-6125
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2064350446
- Cited by
- 259
- References
- 0
- FWCI
- 26.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Liu, C., Tang, J., Ma, Y., Liang, X., Yang, Y., Peng, G., Qi, Q., Jiang, S., Li, J., Du, L., & Li, F. (2015). Receptor Usage and Cell Entry of Porcine Epidemic Diarrhea Coronavirus. Journal of Virology. https://doi.org/10.1128/jvi.00430-15
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