Cited by 8interferon and immune responsesVirology and Viral DiseasesImmune Response and Inflammation

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A Nuclear Export Signal in KHNYN Required for Its Antiviral Activity Evolved as ZAP Emerged in Tetrapods

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Published version of a preprint

Abstract

The interferon system is part of the innate immune response that inhibits viruses and other pathogens. This system emerged approximately 500 million years ago in early vertebrates.

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Metadata

Authors
Lista, M. J., Ficarelli, M., Wilson, H., Kmiec, D., Youle, R. L., Wanford, J., Winstone, H., Odendall, C., Taylor, I. A., Neil, S. J. D., & Swanson, C. M.
Affiliations
  • King’s College London, Department of Infectious Diseases, London, United Kingdom
  • King's College London (GB)
  • The Francis Crick Institute (GB)
Corresponding author
  • Neil, Stuart J. D.
  • Swanson, Chad M.
Venue
Journal of Virology
Published
2023-01-31
Volume
97
Issue
1
Pages
e0087222-e0087222
ISSN
  • 0022-538X (ISSN-L)
  • 1098-5514
OpenAlex
W4315754439
Cited by
8
References
4
Citations by year
2026: 1 · 2025: 3 · 2024: 4
FWCI
0.88
Type
journal article
Language
en
Open access
Locations
  • Journal of Virology (publishedVersion, cc-by)
  • bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nd)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Figshare (submittedVersion, cc-by)
  • Research Portal (King's College London) (submittedVersion, cc-by)
  • The Francis Crick Institute (cc-by)
Funders
  • UKRI | Medical Research Council (MR/S000844/1, MR/R50225X/1, FC001178, MR/W018519/1)
  • Deutsche Forschungsgemeinschaft (KM 5/1-1)
  • Wellcome Trust (WT098049AIA, 206200/Z/17/Z, FC001178)
  • Cancer Research UK (FC001178)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
ZAP, nuclear export signal, interferon-stimulated genes, antiviral innate immunity, tetrapod evolution, protein-protein interaction, gene coevolution
MeSH terms
Animals, Interferons, RNA, Viral, Virus Replication, RNA-Binding Proteins, Evolution, Molecular, Ubiquitin-Protein Ligases, Cullin Proteins, Nuclear Export Signals

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