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A Nuclear Export Signal in KHNYN Required for Its Antiviral Activity Evolved as ZAP Emerged in Tetrapods
Open accessPublished version of a preprint
Abstract
The interferon system is part of the innate immune response that inhibits viruses and other pathogens. This system emerged approximately 500 million years ago in early vertebrates.
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Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764
Deep proteome and transcriptome mapping of a human cancer cell line
Nagaraj, N., Wisniewski, J. R., Geiger, T., Cox, J., Kircher, M., Kelso, J., Pääbo, S., & Mann, M. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.81 · Cited by 979
CG dinucleotide suppression enables antiviral defence targeting non-self RNA
Takata, M. A., Gonçalves-Carneiro, D., Zang, T. M., Soll, S. J., York, A., Blanco-Melo, D., & Bieniasz, P. D. (2017) · Nature · doi:10.1038/nature24039 · Cited by 398
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Metadata
- Authors
- Lista, M. J., Ficarelli, M., Wilson, H., Kmiec, D., Youle, R. L., Wanford, J., Winstone, H., Odendall, C., Taylor, I. A., Neil, S. J. D., & Swanson, C. M.
- Affiliations
- King’s College London, Department of Infectious Diseases, London, United Kingdom
- King's College London (GB)
- The Francis Crick Institute (GB)
- Corresponding author
- Neil, Stuart J. D.
- Swanson, Chad M.
- ORCID
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2023-01-31
- Volume
- 97
- Issue
- 1
- Pages
- e0087222-e0087222
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC9888277
- OpenAlex
- W4315754439
- Cited by
- 8
- References
- 4
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Virology (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Research Portal (King's College London) (submittedVersion, cc-by)
- The Francis Crick Institute (cc-by)
- Funders
- UKRI | Medical Research Council (MR/S000844/1, MR/R50225X/1, FC001178, MR/W018519/1)
- Deutsche Forschungsgemeinschaft (KM 5/1-1)
- Wellcome Trust (WT098049AIA, 206200/Z/17/Z, FC001178)
- Cancer Research UK (FC001178)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- ZAP, nuclear export signal, interferon-stimulated genes, antiviral innate immunity, tetrapod evolution, protein-protein interaction, gene coevolution
- MeSH terms
- Animals, Interferons, RNA, Viral, Virus Replication, RNA-Binding Proteins, Evolution, Molecular, Ubiquitin-Protein Ligases, Cullin Proteins, Nuclear Export Signals
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