NCBI Taxonomy: a comprehensive update on curation, resources and tools
Open accessAbstract
The National Center for Biotechnology Information (NCBI) Taxonomy includes organism names and classifications for every sequence in the nucleotide and protein sequence databases of the International Nucleotide Sequence Database Collaboration. Since the last review of this resource in 2012, it has undergone several improvements. Most notable is the shift from a single SQL database to a series of linked databases tied to a framework of data called NameBank. This means that relations among data elements can be adjusted in more detail, resulting in expanded annotation of synonyms, the ability to flag names with specific nomenclatural properties, enhanced tracking of publications tied to names and improved annotation of scientific authorities and types. Additionally, practices utilized by NCBI Taxonomy curators specific to major taxonomic groups are described, terms peculiar to NCBI Taxonomy are explained, external resources are acknowledged and updates to tools and other resources are documented. Database URL: https://www.ncbi.nlm.nih.gov/taxonomy.
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The National Library of Medicine (NLM) often manually curates biomedical literature databases using ontology and taxonomy concepts due to their established authenticity.
“The National Library of Medicine (NLM) often manually curates biomedical literature databases using ontology and taxonomy concepts due to their established authenticity.22”
From Safeguarding authenticity for mitigating the harms of generative AI: Issues, research agenda, and policies for detection, fact-checking, and ethical AI (2024) · cites this paper as [22]
The NLM employs two prominent taxonomies: the Medical Subject Headings (MeSH) and the NLM National Center of Biotechnology Information (NCBI) Taxonomy.
“Notably, the NLM employs two prominent taxonomies: (a) the Medical Subject Headings (MeSH)23 and (b) the NLM National Center of Biotechnology Information (NCBI) Taxonomy.24,25”
From Safeguarding authenticity for mitigating the harms of generative AI: Issues, research agenda, and policies for detection, fact-checking, and ethical AI (2024) · cites this paper as [25]
Cites
The FAIR Guiding Principles for scientific data management and stewardship
Wilkinson, M. D., Dumontier, M., Aalbersberg, I. J., Appleton, G., Axton, M., Baak, A., Blomberg, N., Boiten, J.-W., da Silva Santos, L. B., Bourne, P. E., et al. (2016) · Scientific Data · doi:10.1038/sdata.2016.18 · Cited by 18,423 · see citing works
O'Leary, N. A., Wright, M. W., Brister, J. R., Ciufo, S., Haddad, D., McVeigh, R., Rajput, B., Robbertse, B., Smith-White, B., Ako-Adjei, D., et al. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkv1189 · Cited by 6,357 · see citing works
Self-citationHow Many Species Are There on Earth and in the Ocean?
Mora, C., Tittensor, D. P., Adl, S., Simpson, A. G. B., & Worm, B. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1001127 · Cited by 3,045 · see citing works
Federhen, S. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr1178 · Cited by 1,436 · see citing works
Assessing the root of bilaterian animals with scalable phylogenomic methods
Hejnol, A., Obst, M., Stamatakis, A., Ott, M., Rouse, G. W., Edgecombe, G. D., Martinez, P., Baguñà, J., Bailly, X., Jondelius, U., et al. (2009) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2009.0896 · Cited by 747 · cited 1× · see citing works
“The classification of major metazoan lineages generally follows the broad consensus of recent phylogenomic studies (68–71) while taking a conservative approach to areas that remain contentious or unresolved (e.g. whether Xenacoelo-morpha is the sister group to all other Bilateria (72) or is a clade…”
BackgroundXenacoelomorpha is the sister group to Nephrozoa
Cannon, J. T., Vellutini, B. C., Smith, J., Ronquist, F., Jondelius, U., & Hejnol, A. (2016) · Nature · doi:10.1038/nature16520 · Cited by 364 · see citing works
Revisiting metazoan phylogeny with genomic sampling of all phyla
Laumer, C. E., Fernández, R., Lemer, S., Combosch, D., Kocot, K. M., Riesgo, A., Andrade, S. C. S., Sterrer, W., Sørensen, M. V., & Giribet, G. (2019) · Proceedings of the Royal Society B: Biological Sciences · doi:10.1098/rspb.2019.0831 · Cited by 360 · cited 2× · see citing works
“These include PACMAD and BOP clades in grasses, the numerous groups and subgroups in the fly genus Drosophila and several important TaxNodes near the root of Metazoa, e.g. Eumetazoa, Bilateria, Amoebozoa or the Sar clade.”
BackgroundA New Spiralian Phylogeny Places the Enigmatic Arrow Worms among Gnathiferans
Marlétaz, F., Peijnenburg, K. T. C. A., Goto, T., Satoh, N., & Rokhsar, D. S. (2019) · Current Biology · doi:10.1016/j.cub.2018.11.042 · Cited by 268 · see citing works
Philippe, H., Poustka, A. J., Chiodin, M., Hoff, K. J., Dessimoz, C., Tomiczek, B., Schiffer, P. H., Müller, S., Domman, D., Horn, M., et al. (2019) · Current Biology · doi:10.1016/j.cub.2019.04.009 · Cited by 152 · see citing works
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Evans, R., O’Neill, M., Pritzel, A., Antropova, N., Senior, A., Green, T., Žídek, A., Bates, R., Blackwell, S., Yim, J., et al. (2021) · doi:10.1101/2021.10.04.463034 · Cited by 3,808 · see citing works
Kim, S., Chen, J., Cheng, T., Gindulyte, A., He, J., He, S., Li, Q., Shoemaker, B. A., Thiessen, P. A., Yu, B., et al. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkac956 · Cited by 3,443 · see citing works
Parks, D. H., Chuvochina, M., Rinke, C., Mussig, A. J., Chaumeil, P.-A., & Hugenholtz, P. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkab776 · Cited by 2,402 · see citing works
Blanco-Míguez, A., Beghini, F., Cumbo, F., McIver, L. J., Thompson, K. N., Zolfo, M., Manghi, P., Dubois, L., Huang, K. D., Thomas, A. M., et al. (2023) · Nature Biotechnology · doi:10.1038/s41587-023-01688-w · Cited by 1,442 · see citing works
The Sequence Read Archive: a decade more of explosive growth
Katz, K., Shutov, O., Lapoint, R., Kimelman, M., Brister, J. R., & O’Sullivan, C. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkab1053 · Cited by 424 · see citing works
The Immune Epitope Database (IEDB): 2024 update
Vita, R., Blazeska, N., Marrama, D., IEDB Curation Team Members, Shackelford, D., Zalman, L., Foos, G., Zarebski, L., Chan, K., Reardon, B., et al. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkae1092 · Cited by 274 · see citing works
Checa-Ros, A., Jeréz-Calero, A., Molina-Carballo, A., Campoy, C., & Muñoz-Hoyos, A. (2021) · Nutrients · doi:10.3390/nu13010249 · Cited by 164 · see citing works
Fukushima, K., & Pollock, D. D. (2023) · Nature Ecology & Evolution · doi:10.1038/s41559-022-01932-7 · Cited by 55 · see citing works
Hamed, A. A., Zachara-Szymanska, M., & Wu, X. (2024) · iScience · doi:10.1016/j.isci.2024.108782 · Cited by 38 · see citing works
High-throughput deep learning variant effect prediction with Sequence UNET
Dunham, A. S., Beltrao, P., & AlQuraishi, M. (2023) · Genome Biology · doi:10.1186/s13059-023-02948-3 · Cited by 31 · see citing works
Burgin, C. J., Zijlstra, J. S., Becker, M. A., Handika, H., Alston, J. M., Widness, J., Liphardt, S., Huckaby, D. G., & Upham, N. S. (2025) · Journal of Mammalogy · doi:10.1093/jmammal/gyaf047 · Cited by 28 · see citing works
Evolution of g-type lysozymes in metazoa: insights into immunity and digestive adaptations
Mukherjee, K., & Moroz, L. L. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1487920 · Cited by 7 · see citing works
Constructing a Draft Indian Cattle Pangenome Using Short-Read Sequencing
Azam, S., Sahu, A., Pandey, N. K., Neupane, M., Van Tassell, C. P., Rosen, B. D., Gandham, R. K., Rath, S. N., & Majumdar, S. S. (2025) · Communications Biology · doi:10.1038/s42003-025-07978-0 · Cited by 5 · see citing works
- Authors
- Schoch, C. L., Ciufo, S., Domrachev, M., Hotton, C. L., Kannan, S., Khovanskaya, R., Leipe, D., Mcveigh, R., O’Neill, K., Robbertse, B., Sharma, S., Soussov, V., Sullivan, J. P., Sun, L., Turner, S., & Karsch-Mizrachi, I.
- Affiliations
- National Institutes of Health (US)
- National Center of Biotechnology Information, National Library of Medicine, National Institutes of Health, 9600 Rockville Pike, Bethesda, MD 20892, USA
- Corresponding author
- Schoch, Conrad L
- ORCID
- Venue
- Database
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-01-01
- Volume
- 2020
- ISSN
- 1758-0463 (ISSN-L)
- PMC
- PMC7408187
- OpenAlex
- W3048090444
- Cited by
- 2,635
- References
- 9
- Citations by year
- 2026: 691 · 2025: 569 · 2024: 465 · 2023: 407 · 2022: 318 · 2021: 172 · 2020: 9 · 2019: 1
- FWCI
- 21.83
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- public-domain
- Locations
- Database (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zenodo (CERN European Organization for Nuclear Research)
- Funders
- Intramural Research Program of the National Library of Medicine
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biomedical Text Mining and Ontologies
- Physical Sciences › Computer Science › Information Systems › Research Data Management Practices
- Keywords
- NCBI taxonomy, taxonomic nomenclature, linked databases, scientific authority, type specimens, publication tracking, sequence databases, taxonomic classification
- MeSH terms
- Animals, Bacteria, Classification, Database Management Systems, Humans, National Library of Medicine (U.S.), Plants, United States, Viruses, Databases, Genetic
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