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A Transgenic Drosophila melanogaster Model To Study Human T-Lymphotropic Virus Oncoprotein Tax-1-Driven Transformation In Vivo
Open accessAbstract
Human T-cell lymphotropic virus type 1 (HTLV-1)-induced adult T-cell leukemia/lymphoma is an aggressive malignancy. HTLV-2 is genetically related to HTLV-1 but does not cause any malignant disease. HTLV-1 Tax transactivator (Tax-1) contributes to leukemogenesis via NF-κB. We describe transgenic Drosophila models expressing Tax in the compound eye and plasmatocytes. We demonstrate that Tax-1 but not Tax-2 induces ommatidial perturbation and increased plasmatocyte proliferation and that the eye phenotype is dependent on Kenny (IKKγ/NEMO), thus validating this new in vivo model.
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Tax modulates expression of NF-κB and enhancer Polycomb Repressive Complex 2 (PRC2), which governs persistence and cellular transformation.
“Tax was shown to modulate the expression of NF-κB and the enhancer Polycomb Repressive Complex 2 (PRC2), which governs persistence and cellular transformation.”
From Current State of Therapeutics for HTLV-1 (2024) · cites this paper as [156]
Citations
Cites
Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation
Matsuoka, M., & Jeang, K.-T. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2111 · Cited by 829
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Current State of Therapeutics for HTLV-1
Wang, T. T., Hirons, A., Doerflinger, M., Morris, K. V., Ledger, S., Purcell, D. F. J., Kelleher, A. D., & Ahlenstiel, C. L. (2024) · Viruses · doi:10.3390/v16101616 · Cited by 22
“The cessation of therapy in HIV is associated with a strong viral rebound to pre-therapeutic plasma viral loads [164–166] and may be similarly mimicked in the incidence of successful treatment of HTLV-1 with ART.”
BackgroundIn vivo antagonistic role of the Human T-Cell Leukemia Virus Type 1 regulatory proteins Tax and HBZ
Akkouche, A., Moodad, S., Hleihel, R., Skayneh, H., Chambeyron, S., El Hajj, H., & Bazarbachi, A. (2021) · PLOS Pathogens · doi:10.1371/journal.ppat.1009219 · Cited by 20
Self-citation
Metadata
- Authors
- Shirinian, M., Kambris, Z., Hamadeh, L., Grabbe, C., Journo, C., Mahieux, R., & Bazarbachi, A.
- Affiliations
- American University of Beirut (LB)
- Umeå University (SE)
- Lyon 1 Université (FR)
- ORCID
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2015-08
- Volume
- 89
- Issue
- 15
- Pages
- 8092-8095
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC4505646
- OpenAlex
- W2110025244
- Cited by
- 29
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 6 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 1
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DiVA at Umeå University (Umeå University) (submittedVersion, other-oa)
- HAL (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
- Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- HTLV-1, adult T-cell leukemia/lymphoma, NF-κB signaling, plasmatocytes, leukemogenesis
- MeSH terms
- Animals, Cell Transformation, Viral, Disease Models, Animal, Drosophila melanogaster, Eye, Humans, Human T-lymphotropic virus 2, Human T-lymphotropic virus 1, HTLV-I Infections, Gene Products, tax
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