The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Human Immunodeficiency Virus Type 1 Controllers but Not Noncontrollers Maintain CD4 T Cells Coexpressing Three Cytokines
Open accessAbstract
Here, we evaluate the cytokine coexpression profiles of human immunodeficiency virus (HIV)-specific CD4 T cells for the expression of the cytokines gamma interferon (IFN-γ), interleukin-2, and tumor necrosis factor alpha. In controllers, CD4 T cells producing three or two cytokines (triple producers and double producers, respectively) represented >50% of the total response. In contrast, in noncontrollers ∼75% of responding cells produced only one cytokine (single producers), mostly IFN-γ. Cells producing three cytokines were functionally superior to those producing single cytokines and showed an inverse correlation (P< 0.001) with viral load. These results demonstrate a strong association between the maintenance of highly functional CD4 T cells producing three cytokines and control of HIV-1.
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Cites
CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes
Janssen, E. M., Lemmens, E. E., Wolfe, T., Christen, U., von Herrath, M. G., & Schoenberger, S. P. (2003) · Nature · doi:10.1038/nature01441 · Cited by 1,635
Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help
Sun, J. C., & Bevan, M. J. (2003) · Science · doi:10.1126/science.1083317 · Cited by 1,213
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Day, C. L., Abrahams, D. A., Lerumo, L., Janse van Rensburg, E., Stone, L., O’rie, T., Pienaar, B., de Kock, M., Kaplan, G., Mahomed, H., et al. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1101122 · Cited by 346
Metadata
- Authors
- Kannanganat, S., Kapogiannis, B. G., Ibegbu, C., Chennareddi, L., Goepfert, P., Robinson, H. L., Lennox, J., & Amara, R. R.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2007-11
- Volume
- 81
- Issue
- 21
- Pages
- 12071-12076
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2149164390
- Cited by
- 159
- References
- 2
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Kannanganat, S., Kapogiannis, B. G., Ibegbu, C., Chennareddi, L., Goepfert, P., Robinson, H. L., Lennox, J., & Amara, R. R. (2007). Human Immunodeficiency Virus Type 1 Controllers but Not Noncontrollers Maintain CD4 T Cells Coexpressing Three Cytokines. Journal of Virology. https://doi.org/10.1128/jvi.01261-07
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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