Cited by 1,213T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune responses and vaccinations

Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

Open access
Sun, Joseph C., Bevan, Michael J.·2003·Science

Abstract

The CD8 + cytotoxic T cell response to pathogens is thought to be CD4 + helper T cell independent because infectious agents provide their own inflammatory signals. Mice that lack CD4 + T cells mount a primary CD8 response to Listeria monocytogenes equal to that of wild-type mice and rapidly clear the infection. However, protective memory to a challenge is gradually lost in the former animals. Memory CD8 + T cells from normal mice can respond rapidly, but memory CD8 + T cells that are generated without CD4 help are defective in their ability to respond to secondary encounters with antigen. The results highlight a previously undescribed role for CD4 help in promoting protective CD8 memory development.

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Crossref · 10.1126/science.1083317

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  • Without licensing signal, activated helpless CTLs function as primary effector T cells but have a short lifespan or die via activation-induced cell death after subsequent antigen exposure.

    “Without this additional signal, the activated ‘helpless’ CTL function as primary effector T cells but with a short lifespan69 or die via activation-induced cell death following subsequent exposure to antigen70,71.”

    From Immunogenic and tolerogenic cell death (2009) · cites this paper as [70]

  • The death of helpless CTLs is mediated by TRAIL, which triggers apoptosis in helpless CTL and other activated T cells.

    “The latter cell death is mediated by expression of the death ligand TRAIL, which triggers apoptosis in the helpless CTL as well as other activated T cells70,72.”

    From Immunogenic and tolerogenic cell death (2009) · cites this paper as [70]

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Research works printed but not linked: 2

  1. [9]Ladel CH, Flesch IE, Arnoldi J, Kaufmann SH. J. Immunol. 1994;153:3116. [PubMed] [Google Scholar]
  2. [23]Edelson BT, Cossart P, Unanue ER. J. Immunol. 1999;163:4087. [PubMed] [Google Scholar]

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Authors
Sun, J. C., & Bevan, M. J.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
Bevan, Michael J.
Venue
Science
Published
2003-04-11
Volume
300
Issue
5617
Pages
339-342
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2076534074
Cited by
1,213
References
26
Citations by year
2026: 4 · 2025: 16 · 2024: 18 · 2023: 18 · 2022: 19 · 2021: 31 · 2020: 28 · 2019: 18 · 2018: 24 · 2017: 21 · 2016: 28 · 2015: 32 · 2014: 51 · 2013: 46 · 2012: 58
FWCI
40.97
Type
journal article
Language
en
Open access
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Howard Hughes Medical Institute
  • National Institute of Allergy and Infectious Diseases (R01AI019335, AI-19335)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords
CD8+ T cell memory, CD4+ T cell help, Listeria monocytogenes, acute infection, CD4-deficient mice, cytotoxic T lymphocytes, protective immunity
MeSH terms
Animals, Cytotoxicity, Immunologic, Genes, MHC Class II, T-Lymphocytes, Helper-Inducer, Immunization, Immunologic Memory, Interferon-gamma, Listeriosis, Listeria monocytogenes, Mice, Inbred C57BL, Ovalbumin, T-Lymphocyte Subsets, CD8-Positive T-Lymphocytes, Adoptive Transfer, Mice

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