The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Tiered Categorization of a Diverse Panel of HIV-1 Env Pseudoviruses for Assessment of Neutralizing Antibodies
Open accessAbstract
The restricted neutralization breadth of vaccine-elicited antibodies is a major limitation of current human immunodeficiency virus-1 (HIV-1) candidate vaccines. In order to permit the efficient identification of vaccines with enhanced capacity for eliciting cross-reactive neutralizing antibodies (NAbs) and to assess the overall breadth and potency of vaccine-elicited NAb reactivity, we assembled a panel of 109 molecularly cloned HIV-1 Env pseudoviruses representing a broad range of genetic and geographic diversity. Viral isolates from all major circulating genetic subtypes were included, as were viruses derived shortly after transmission and during the early and chronic stages of infection. We assembled a panel of genetically diverse HIV-1-positive (HIV-1 + ) plasma pools to assess the neutralization sensitivities of the entire virus panel. When the viruses were rank ordered according to the average sensitivity to neutralization by the HIV-1 + plasmas, a continuum of average sensitivity was observed. Clustering analysis of the patterns of sensitivity defined four subgroups of viruses: those having very high (tier 1A), above-average (tier 1B), moderate (tier 2), or low (tier 3) sensitivity to antibody-mediated neutralization. We also investigated potential associations between characteristics of the viral isolates (clade, stage of infection, and source of virus) and sensitivity to NAb. In particular, higher levels of NAb activity were observed when the virus and plasma pool were matched in clade. These data provide the first systematic assessment of the overall neutralization sensitivities of a genetically and geographically diverse panel of circulating HIV-1 strains. These reference viruses can facilitate the systematic characterization of NAb responses elicited by candidate vaccine immunogens.
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Cites
Longitudinal data analysis using generalized linear models
LIANG, K.-Y., & ZEGER, S. L. (1986) · Biometrika · doi:10.1093/biomet/73.1.13 · Cited by 18,550
Estimating the Number of Clusters in a Data Set Via the Gap Statistic
Tibshirani, R., Walther, G., & Hastie, T. (2001) · Journal of the Royal Statistical Society Series B: Statistical Methodology · doi:10.1111/1467-9868.00293 · Cited by 6,205
A dendrite method for cluster analysis
Caliński, T., & Harabasz, J. (1974) · Communications in Statistics · doi:10.1080/03610927408827101 · Cited by 4,480
Gallo, R. C., Salahuddin, S. Z., Popovic, M., Shearer, G. M., Kaplan, M., Haynes, B. F., Palker, T. J., Redfield, R., Oleske, J., Safai, B., et al. (1984) · Science · doi:10.1126/science.6200936 · Cited by 3,641
Kwong, P. D., Wyatt, R., Robinson, J., Sweet, R. W., Sodroski, J., & Hendrickson, W. A. (1998) · Nature · doi:10.1038/31405 · Cited by 2,964
Antibody neutralization and escape by HIV-1
Wei, X., Decker, J. M., Wang, S., Hui, H., Kappes, J. C., Wu, X., Salazar-Gonzalez, J. F., Salazar, M. G., Kilby, J. M., Saag, M. S., et al. (2003) · Nature · doi:10.1038/nature01470 · Cited by 2,421
Keele, B. F., Giorgi, E. E., Salazar-Gonzalez, J. F., Decker, J. M., Pham, K. T., Salazar, M. G., Sun, C., Grayson, T., Wang, S., Li, H., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802203105 · Cited by 1,912
Self-citationFiebig, E. W., Wright, D. J., Rawal, B. D., Garrett, P. E., Schumacher, R. T., Peddada, L., Heldebrant, C., Smith, R., Conrad, A., Kleinman, S. H., et al. (2003) · AIDS · doi:10.1097/00002030-200309050-00005 · Cited by 1,305
Mascola, J. R., Stiegler, G., VanCott, T. C., Katinger, H., Carpenter, C. B., Hanson, C. E., Beary, H., Hayes, D., Frankel, S. S., Birx, D. L., et al. (2000) · Nature Medicine · doi:10.1038/72318 · Cited by 1,250
Self-citationPlatt, E. J., Wehrly, K., Kuhmann, S. E., Chesebro, B., & Kabat, D. (1998) · Journal of Virology · doi:10.1128/jvi.72.4.2855-2864.1998 · Cited by 1,219
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Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition
Corey, L., Gilbert, P. B., Juraska, M., Montefiori, D. C., Morris, L., Karuna, S. T., Edupuganti, S., Mgodi, N. M., deCamp, A. C., Rudnicki, E., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2031738 · Cited by 538
Self-citationBogers, W. M., Oostermeijer, H., Mooij, P., Koopman, G., Verschoor, E. J., Davis, D., Ulmer, J. B., Brito, L. A., Cu, Y., Banerjee, K., et al. (2015) · Journal of Infectious Diseases · doi:10.1093/infdis/jiu522 · Cited by 181
Self-citationHammonds, J. E., Beeman, N., Ding, L., Takushi, S., Francis, A. C., Wang, J.-J., Melikyan, G. B., & Spearman, P. (2017) · PLOS Pathogens · doi:10.1371/journal.ppat.1006181 · Cited by 110
Intermediate conformations of CD4-bound HIV-1 Env heterotrimers
Dam, K.-M. A., Fan, C., Yang, Z., & Bjorkman, P. J. (2023) · Nature · doi:10.1038/s41586-023-06639-8 · Cited by 50
Metadata
- Authors
- Seaman, M. S., Janes, H., Hawkins, N., Grandpre, L. E., Devoy, C., Giri, A., Coffey, R. T., Harris, L., Wood, B., Daniels, M. G., Bhattacharya, T., Lapedes, A., Polonis, V. R., McCutchan, F. E., Gilbert, P. B., Self, S. G., Korber, B. T., Montefiori, D. C., & Mascola, J. R.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2010-02
- Volume
- 84
- Issue
- 3
- Pages
- 1439-1452
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2122210861
- Cited by
- 632
- References
- 41
- FWCI
- 11.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Seaman, M. S., Janes, H., Hawkins, N., Grandpre, L. E., Devoy, C., Giri, A., Coffey, R. T., Harris, L., Wood, B., Daniels, M. G., Bhattacharya, T., Lapedes, A., Polonis, V. R., McCutchan, F. E., Gilbert, P. B., Self, S. G., Korber, B. T., Montefiori, D. C., & Mascola, J. R. (2010). Tiered Categorization of a Diverse Panel of HIV-1 Env Pseudoviruses for Assessment of Neutralizing Antibodies. Journal of Virology. https://doi.org/10.1128/jvi.02108-09
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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