The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Epithelial Cells Lining Salivary Gland Ducts Are Early Target Cells of Severe Acute Respiratory Syndrome Coronavirus Infection in the Upper Respiratory Tracts of Rhesus Macaques
Open accessAbstract
The shedding of severe acute respiratory syndrome coronavirus (SARS-CoV) into saliva droplets plays a critical role in viral transmission. The source of high viral loads in saliva, however, remains elusive. Here we investigate the early target cells of infection in the entire array of respiratory tissues in Chinese macaques after intranasal inoculations with a single-cycle pseudotyped virus and a pathogenic SARS-CoV. We found that angiotensin-converting enzyme 2-positive (ACE2+) cells were widely distributed in the upper respiratory tract, and ACE2+epithelial cells lining salivary gland ducts were the early target cells productively infected. Our findings also have implications for SARS-CoV early diagnosis and prevention.
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Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
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A Novel Coronavirus Associated with Severe Acute Respiratory Syndrome
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A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury
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Self-citationCoronavirus as a possible cause of severe acute respiratory syndrome
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Bats Are Natural Reservoirs of SARS-Like Coronaviruses
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Self-citationThe cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys
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Multiple organ infection and the pathogenesis of SARS
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Cited by
To, K. K.-W., Tsang, O. T.-Y., Leung, W.-S., Tam, A. R., Wu, T.-C., Lung, D. C., Yip, C. C.-Y., Cai, J.-P., Chan, J. M.-C., Chik, T. S.-H., et al. (2020) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(20)30196-1 · Cited by 3,066
Self-citationConsistent Detection of 2019 Novel Coronavirus in Saliva
To, K. K.-W., Tsang, O. T.-Y., Yip, C. C.-Y., Chan, K.-H., Wu, T.-C., Chan, J. M.-C., Leung, W.-S., Chik, T. S.-H., Choi, C. Y.-C., Kandamby, D. H., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa149 · Cited by 1,873
Ciotti, M., Ciccozzi, M., Terrinoni, A., Jiang, W.-C., Wang, C.-B., & Bernardini, S. (2020) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2020.1783198 · Cited by 1,514
The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755
Ortiz-Prado, E., Simbaña-Rivera, K., Gómez- Barreno, L., Rubio-Neira, M., Guaman, L. P., Kyriakidis, N. C., Muslin, C., Jaramillo, A. M. G., Barba-Ostria, C., Cevallos-Robalino, D., et al. (2020) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2020.115094 · Cited by 458
Metadata
- Authors
- Liu, L., Wei, Q., Alvarez, X., Wang, H., Du, Y., Zhu, H., Jiang, H., Zhou, J., Lam, P., Zhang, L., Lackner, A., Qin, C., & Chen, Z.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2011-04-15
- Volume
- 85
- Issue
- 8
- Pages
- 4025-4030
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2111157257
- Cited by
- 450
- References
- 45
- FWCI
- 0.20
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Epithelial Cells Lining Salivary Gland Ducts Are Early Target Cells of Severe Acute Respiratory Syndrome Coronavirus Infection in the Upper Respiratory Tracts of Rhesus Macaques. https://app.cochat.ai/papers/10.1128/jvi.02292-10
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- Liu, L., Wei, Q., Alvarez, X., Wang, H., Du, Y., Zhu, H., Jiang, H., Zhou, J., Lam, P., Zhang, L., Lackner, A., Qin, C., & Chen, Z. (2011). Epithelial Cells Lining Salivary Gland Ducts Are Early Target Cells of Severe Acute Respiratory Syndrome Coronavirus Infection in the Upper Respiratory Tracts of Rhesus Macaques. Journal of Virology. https://doi.org/10.1128/jvi.02292-10
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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