Upregulation of the Chemokine (C-C Motif) Ligand 2 via a Severe Acute Respiratory Syndrome Coronavirus Spike-ACE2 Signaling Pathway
Open accessAbstract
Severe acute respiratory syndrome coronavirus (SARS-CoV) was identified to be the causative agent of SARS with atypical pneumonia. Angiotensin-converting enzyme 2 (ACE2) is the major receptor for SARS-CoV. It is not clear whether ACE2 conveys signals from the cell surface to the nucleus and regulates expression of cellular genes upon SARS-CoV infection. To understand the pathogenesis of SARS-CoV, human type II pneumocyte (A549) cells were incubated with the viral spike protein or with SARS-CoV virus-like particles containing the viral spike protein to examine cytokine modulation in lung cells. Results from oligonucleotide-based microarray, real-time PCR, and enzyme-linked immunosorbent assays indicated an upregulation of the fibrosis-associated chemokine (C-C motif) ligand 2 (CCL2) by the viral spike protein and the virus-like particles. The upregulation of CCL2 by SARS-CoV spike protein was mainly mediated by extracellular signal-regulated kinase 1 and 2 (ERK1/2) and AP-1 but not the IκBα-NF-κB signaling pathway. In addition, Ras and Raf upstream of the ERK1/2 signaling pathway were involved in the upregulation of CCL2. Furthermore, ACE2 receptor was activated by casein kinase II-mediated phosphorylation in cells pretreated with the virus-like particles containing spike protein. These results indicate that SARS-CoV spike protein triggers ACE2 signaling and activates fibrosis-associated CCL2 expression through the Ras-ERK-AP-1 pathway.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Upregulation of the fibrosis-associated chemokine CCL2 was shown to be mediated by ERK1/2 in human lung A549 epithelial cells incubated with SARS-CoV spike protein or SARS virus-like particles.
“Upregulation of the fibrosis-associated chemokine CCL2 was shown to be mediated by ERK1/2 in human lung A549 epithelial cells incubated with SARS-CoV spike (S) protein or SARS virus-like particles (VLPs) (25).”
From Into the Eye of the Cytokine Storm (2012) · cites this paper as [25]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1006/abio.1987.9999 · Cited by 65,240 · see citing works
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus
Li, W., Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., et al. (2003) · Nature · doi:10.1038/nature02145 · Cited by 5,923 · see citing works
Mammalian MAP kinase signalling cascades
Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,118 · see citing works
Identification of a novel coronavirus in patients with severe acute respiratory syndrome
Drosten, C., Günther, S., Preiser, W., van der Werf, S., Brodt, H.-R., Becker, S., Rabenau, H., Panning, M., Kolesnikova, L., Fouchier, R. A. M., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030747 · Cited by 4,574 · see citing works
A Novel Coronavirus Associated with Severe Acute Respiratory Syndrome
Tg, K., Erdman, D. D., Cs, G., Zaki, Peret, T. C. T., Emery, S. L., Tong, S., Urbani, C., Comer, J. A., Lim, W., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030781 · Cited by 4,345 · see citing works
Kyriakis, J. M., & Avruch, J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.807 · Cited by 3,369 · see citing works
Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome
Rota, P. A., Oberste, M. S., Monroe, S. S., Nix, W. A., Campagnoli, R. P., Icenogle, J. P., Peñaranda, S., Bankamp, B., Maher, K., Chen, M., et al. (2003) · Science · doi:10.1126/science.1085952 · Cited by 2,477 · see citing works
The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases
Karin, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16483 · Cited by 2,432 · see citing works
A Human Homolog of Angiotensin-converting Enzyme
Tipnis, S. R., Hooper, N. M., Hyde, R., Karran, E. H., Christie, G., & Turner, A. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002615200 · Cited by 2,032 · see citing works
The Genome Sequence of the SARS-Associated Coronavirus
Marra, M. A., Jones, S. J. M., Astell, C. R., Holt, R. A., Brooks-Wilson, A. R., Butterfield, Y. S. N., Khattra, J. S., Asano, J. K., Barber, S., Chan, S. Y., et al. (2003) · Science · doi:10.1126/science.1085953 · Cited by 2,017 · see citing works
Phosphorylation of c-jun mediated by MAP kinases
Pulverer, B., Kyriakis, J. M., Avruch, J., Nikolakaki, E., & Woodgett, J. R. (1991) · Nature · doi:10.1038/353670a0 · Cited by 1,470 · see citing works
Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome
Kuiken, T., Fouchier, R. A. M., Schutten, M., Rimmelzwaan, G. F., van Amerongen, G., van Riel, D. A. J., Laman, J. D., de Jong, T., van Doornum, G., Lim, W. W. L., et al. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13967-0 · Cited by 1,015 · see citing works
Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1
Gu, L., Tseng, S., Horner, R. M., Tam‐Amersdorfer, C., Loda, M. F., & Rollins, B. J. (2000) · Nature · doi:10.1038/35006097 · Cited by 832 · see citing works
Lambert, D., Yarski, M., Warner, F. J., Thornhill, P., Parkin, E. T., Smith, A. I., Hooper, N. M., & Turner, A. J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505111200 · Cited by 697 · see citing works
CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus
Jeffers, S. A., Tusell, S. M., Gillim-Ross, L., Hemmila, E. M., Achenbach, J. E., Babcock, G. J., Thomas, W. D., Thackray, L. B., Young, M. D., Mason, R. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403812101 · Cited by 606 · see citing works
Haga, S., Yamamoto, N., Nakai-Murakami, C., Osawa, Y., Tokunaga, K., Sata, T., Yamamoto, N., Sasazuki, T., & Ishizaka, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711241105 · Cited by 522 · see citing works
Chemokine up-regulation in SARS-coronavirus–infected, monocyte-derived human dendritic cells
Law, H., Cheung, C. Y., Ng, H. Y., Sia, S. F., Chan, Y. O., Luk, W., Nicholls, J. M., Peiris, M. J. S., & Lau, Y. (2005) · Blood · doi:10.1182/blood-2004-10-4166 · Cited by 467 · see citing works
Cheung, C. Y., Poon, L. L. M., Ng, I. H. Y., Luk, W., Sia, S. F., Wu, M. H. S., Chan, K., Yuen, K., Gordon, S., Guan, Y., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.12.7819-7826.2005 · Cited by 461 · see citing works
Gharaee‐Kermani, M., Denholm, E. M., & Phan, S. H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17779 · Cited by 433 · see citing works
He, L., Ding, Y., Zhang, Q., Che, X., He, Y., Shen, H., Wang, H., Li, Z., Zhao, L., Geng, J., et al. (2006) · The Journal of Pathology · doi:10.1002/path.2067 · Cited by 365 · see citing works
Analysis of Serum Cytokines in Patients with Severe Acute Respiratory Syndrome
Zhang, Y., Li, J., Zhan, Y., Wu, L., Xue-ying, Y., Zhang, W., Ye, L., Xu, S., Sun, R., Wang, Y., et al. (2004) · Infection and Immunity · doi:10.1128/iai.72.8.4410-4415.2004 · Cited by 336 · see citing works
Characterization of Cytokine/Chemokine Profiles of Severe Acute Respiratory Syndrome
Jiang, Y., Xu, J., Zhou, C., Wu, Z., Zhong, S.-Q., Liu, J., Luo, W., Chen, T., Qin, Q., & Deng, P. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200407-857oc · Cited by 317 · see citing works
Transcriptional Regulation of The Human Monocyte Chemoattractant Protein-1 Gene
Ueda, A., Ishigatsubo, Y., Okubo, T., & Yoshimura, T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.49.31092 · Cited by 309 · see citing works
Significant Involvement of CCL2 (MCP-1) in Inflammatory Disorders of the Lung
Rose, C. E., Sung, S.-S. J., & Fu, S. M. (2003) · Microcirculation · doi:10.1038/sj.mn.7800193 · Cited by 239 · see citing works
To, K. F., TONG, J. H. M., Chan, P. K. S., Au, F. W. L., Chim, S. S. C., Chan, K. A., Cheung, J. L. K., Liu, E. Y. M., Tse, G. M.-K., Lo, A. W. I., et al. (2004) · The Journal of Pathology · doi:10.1002/path.1510 · Cited by 176 · see citing works
Monje, P. V., Marinissen, M. J., & Gutkind, J. S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.19.7030-7043.2003 · Cited by 148 · see citing works
Significant Involvement of CCL2 (MCP-1) in Inflammatory Disorders of the Lung
ROSE, C. E., Sung, S. J., & FU, S. M. (2003) · Microcirculation · doi:10.1080/mic.10.3-4.273.288 · Cited by 145 · see citing works
Modeling the Early Events of Severe Acute Respiratory Syndrome Coronavirus Infection In Vitro
Yen, Y., Liao, F., Hsiao, C.-H., Kao, C., Chen, Y., & Wu‐Hsieh, B. A. (2006) · Journal of Virology · doi:10.1128/jvi.80.6.2684-2693.2006 · Cited by 140 · see citing works
Angiotensin-Converting Enzyme Is Involved in Outside-In Signaling in Endothelial Cells
Kohlstedt, K., Brandes, R. P., Müller‐Esterl, W., Busse, R., & Fleming, I. (2003) · Circulation Research · doi:10.1161/01.res.0000107195.13573.e4 · Cited by 134 · see citing works
Chang, Y., Liu, C. Y. Y., Chiang, B., Chao, Y., & Chen, C. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.12.7602 · Cited by 131 · see citing works
Ping, D., Jones, P. L., & Boss, J. M. (1996) · Immunity · doi:10.1016/s1074-7613(00)80412-4 · Cited by 125 · see citing works
Activation of AP-1 signal transduction pathway by SARS coronavirus nucleocapsid protein
He, R., Leeson, A., Andonov, A. P., Li, Y., Bastien, N., Cao, J., Osiowy, C., Dobie, F. A., Cutts, T. A., Ballantine, M., et al. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.10.075 · Cited by 121 · see citing works
Human‐immundeficiency‐virus‐type‐1‐encoded Vpu protein is phosphorylated by casein kinase II
SCHUBERT, U., Schneider, T., Henklein, P., Hoffmann, K. H., BERTHOLD, E., Häuser, H., Pauli, G., & Porstmann, T. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb16707.x · Cited by 105 · see citing works
The Nucleolin Binding Activity of Hepatitis Delta Antigen Is Associated with Nucleolus Targeting
Lee, C., Chang, S. C., Chen, C., & Chang, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.13.7650 · Cited by 98 · see citing works
Self-citationAngiotensin-converting enzyme 2 and new insights into the renin–angiotensin system
Lambert, D., Hooper, N. M., & Turner, A. J. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.08.012 · Cited by 85 · see citing works
Kohlstedt, K., Shoghi, F., Müller‐Esterl, W., Busse, R., & Fleming, I. (2002) · Circulation Research · doi:10.1161/01.res.0000038114.17939.c8 · Cited by 81 · see citing works
Wang, N., Verna, L. K., Hardy, S. F., Forsayeth, J., Zhu, Y., & Stemerman, M. B. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.9.2078 · Cited by 76 · see citing works
Hsueh, P., Hsiao, C.-H., Yeh, S., Wang, W., Chen, P., Wang, J., Chang, S.-C., Kao, C., & Yang, P. (2003) · Emerging infectious diseases · doi:10.3201/eid0909.030367 · Cited by 73 · see citing works
Self-citationCho, N., Seong, S., Huh, M.-S., Kim, N., Choi, M., & Kim, I.-S. (2002) · Infection and Immunity · doi:10.1128/iai.70.9.4841-4850.2002 · Cited by 55 · see citing works
Chang, M., Sun, C., Chen, C. J., & Chang, S. (1993) · Journal of Virology · doi:10.1128/jvi.67.5.2529-2536.1993 · Cited by 54 · see citing works
Self-citationWu, S., Chang, S. C., Wu, H., Liao, P., & Chang, M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802821200 · Cited by 50 · see citing works
Self-citationSurface ultrastructure of SARS coronavirus revealed by atomic force microscopy
Lin, S., Lee, C.-K., Lee, S.-Y., Kao, C., Lin, C., Wang, A.-B., Hsu, S., & Huang, L.-S. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00593.x · Cited by 46 · see citing works
Self-citationCoordinate induction of IFN-α and -γ by SARS-CoV also in the absence of virus replication
Castilletti, C., Bordi, L., Lalle, E., Rozera, G., Poccia, F., Agrati, C., Abbate, I., & Capobianchi, M. R. (2005) · Virology · doi:10.1016/j.virol.2005.07.015 · Cited by 41 · see citing works
Lu, C., Huang, H.-Y., Yang, T.-L., Chang, L., Lee, C., & Huang, L. (2008) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-008-0495-5 · Cited by 27 · see citing works
Li, Y.-S., & Kolattukudy, P. E. (1994) · Molecular and Cellular Biochemistry · doi:10.1007/bf00926175 · Cited by 24 · see citing works
Tsai, C.-W., Chang, S. C., & Chang, M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26085 · Cited by 17 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Into the Eye of the Cytokine Storm
Tisoncik, J. R., Korth, M. J., Simmons, C. P., Farrar, J., Martin, T. R., & Katze, M. G. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05015-11 · Cited by 1,940 · see citing works
Human Coronavirus: Host-Pathogen Interaction.
Fung, T. S., & Liu, D. X. (2019) · Annual Review of Microbiology · doi:10.1146/annurev-micro-020518-115759 · Cited by 907 · see citing works
SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19
Zhang, S., Liu, Y., Wang, X., Li, H., Li, H., Wang, Y., Liu, M., Zhao, X., Xie, Y., Yang, Y., et al. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00954-7 · Cited by 662 · see citing works
Human Coronaviruses: A Review of Virus–Host Interactions
Lim, Y. X., Ng, Y. W., Tam, J. P., & Liu, D. X. (2016) · Diseases · doi:10.3390/diseases4030026 · Cited by 585 · see citing works
The molecular virology of coronaviruses
Hartenian, E., Nandakumar, D., Lari, A., Ly, M., Tucker, J. M., & Glaunsinger, B. A. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev120.013930 · Cited by 513 · see citing works
Nanotechnology for COVID-19: Therapeutics and Vaccine Research
Chauhan, G., Madou, M. J., Kalra, S., Chopra, V., Ghosh, D., & Martinez-Chapa, S. O. (2020) · ACS Nano · doi:10.1021/acsnano.0c04006 · Cited by 382 · see citing works
Protein kinase CK2: a potential therapeutic target for diverse human diseases
Borgo, C., D’Amore, C., Sarno, S., Salvi, M., & Ruzzene, M. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00567-7 · Cited by 369 · see citing works
Critical Determinants of Cytokine Storm and Type I Interferon Response in COVID-19 Pathogenesis
Ramasamy, S., & Subbian, S. (2021) · Clinical Microbiology Reviews · doi:10.1128/cmr.00299-20 · Cited by 291 · see citing works
Herbal immune-boosters: Substantial warriors of pandemic Covid-19 battle
Khanna, K., Kohli, S. K., Kaur, R., Bhardwaj, A., Bhardwaj, V., Ohri, P., Sharma, A., Ahmad, A., Bhardwaj, R., & Ahmad, P. (2020) · Phytomedicine · doi:10.1016/j.phymed.2020.153361 · Cited by 194 · see citing works
Kang, S., Peng, W., Zhu, Y., Lu, S. Y., Zhou, M., Lin, W., Wu, W., Huang, S., Jiang, L., Luo, X., et al. (2020) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2020.105950 · Cited by 166 · see citing works
Surface vimentin is critical for the cell entry of SARS-CoV
Yu, Y. T.-C., Chien, S.-C., Chen, I.-Y., Lai, C.-T., Tsay, Y., Chang, S. C., & Chang, M. (2016) · Journal of Biomedical Science · doi:10.1186/s12929-016-0234-7 · Cited by 160 · see citing works
Self-citationMelatonin potentials against viral infections including COVID-19: Current evidence and new findings
Juybari, K. B., Pourhanifeh, M. H., Hosseinzadeh, A., Hemati, K., & Mehrzadi, S. (2020) · Virus Research · doi:10.1016/j.virusres.2020.198108 · Cited by 129 · see citing works
Geng, Y., Wei, Z.-Y., Qian, H., Huang, J., Lodato, R. F., & Castriotta, R. J. (2020) · Cardiovascular Pathology · doi:10.1016/j.carpath.2020.107228 · Cited by 130 · see citing works
Sallenave, J., & Guillot, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01229 · Cited by 125 · see citing works
Antioxidant, anti-inflammatory and immunomodulatory roles of vitamins in COVID-19 therapy
Pisoschi, A. M., Pop, A., Iordache, F., Stanca, L., Geicu, O. I., Bîlteanu, L., & Șerban, A. I. (2022) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2022.114175 · Cited by 114 · see citing works
Sharma, P. K., Kim, E., Mishra, S., Ganbold, E., Seong, R., Kaushik, A. K., & Kim, N. (2021) · ACS Sensors · doi:10.1021/acssensors.1c01437 · Cited by 109 · see citing works
PAK1-blockers: Potential Therapeutics against COVID-19
Maruta, H., & He, H. Z. (2020) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2020.100039 · Cited by 108 · see citing works
Wicik, Z., Eyileten, C., Jakubik, D., Simões, S. N., Martins, D., Pavão, R., Siller-Matula, J. M., & Postula, M. A. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9113743 · Cited by 100 · see citing works
Annweiler, C., Beaudenon, M., Gautier, J., Simon, R., Dubée, V., Gonsard, J., Parot‐Schinkel, E., on behalf of the COVIT-TRIAL study group, Aïdoud, A., Albaret, G., et al. (2020) · Trials · doi:10.1186/s13063-020-04928-5 · Cited by 90 · see citing works
Kumar, A., Narayan, R. K., Kumari, C., Faiq, M. A., Kulandhasamy, M., Kant, K., & Pareek, V. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110320 · Cited by 79 · see citing works
Al-Qahtani, A. A., Lyroni, K., Aznaourova, M., Tseliou, M., Al‐Anazi, M. R., Al‐Ahdal, M. N., Alkahtani, S. H., Sourvinos, G., & Tsatsanis, C. (2017) · Oncotarget · doi:10.18632/oncotarget.14754 · Cited by 78 · see citing works
Potential role of ACE2-related microRNAs in COVID-19-associated nephropathy
Widiasta, A., Sribudiani, Y., Nugrahapraja, H., Hilmanto, D., Sekarwana, N., & Rachmadi, D. (2020) · Non-coding RNA Research · doi:10.1016/j.ncrna.2020.09.001 · Cited by 75 · see citing works
Suzuki, Y., & Gychka, S. G. (2021) · Vaccines · doi:10.3390/vaccines9010036 · Cited by 71 · see citing works
Shahinozzaman, M., Basak, B., Emran, R., Rozario, P., & Obanda, D. N. (2020) · Fitoterapia · doi:10.1016/j.fitote.2020.104775 · Cited by 72 · see citing works
Influence of COVID-19 on Cerebrovascular Disease and its Possible Mechanism
Fan, H., Tang, X., Song, Y., Liu, P., & Chen, Y. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s251173 · Cited by 66 · see citing works
Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19
Pedrosa, M. A., Valenzuela, R., Garrido‐Gil, P., Labandeira, C. M., Navarro, G., Franco, R., Labandeira-García, J. L., & Rodriguez-Perez, A. I. (2021) · Clinical Science · doi:10.1042/cs20201511 · Cited by 66 · see citing works
Nanobiotechnology as a platform for the diagnosis of COVID-19: a review
Abdelhamid, H. N., & Badr, G. (2021) · Nanotechnology for Environmental Engineering · doi:10.1007/s41204-021-00109-0 · Cited by 60 · see citing works
Rather, I. A., Choi, S. B., Kamli, M. R., Hakeem, K. R., Sabir, J. S. M., Park, Y.-H., & Hor, Y.-Y. (2021) · Vaccines · doi:10.3390/vaccines9101067 · Cited by 58 · see citing works
Distribution of COVID-19 and Phylogenetic Tree Construction of SARS-CoV-2 in Indonesia
Turista, D. D. R., Islamy, A., Kharisma, V. D., & Ansori, A. N. M. (2020) · Journal of Pure and Applied Microbiology · doi:10.22207/jpam.14.spl1.42 · Cited by 55 · see citing works
Öz, M., & Lorke, D. E. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.111193 · Cited by 55 · see citing works
Hou, X., Zhang, X., Wu, X. Z., Lu, M., Wang, D., Xu, M., Wang, H., Liang, T., Dai, J., Duan, H., et al. (2020) · Molecular & Cellular Proteomics · doi:10.1074/mcp.rp120.002128 · Cited by 53 · see citing works
Forsyth, C. B., Zhang, L., Bhushan, A., Swanson, B. A., Zhang, L., Mamede, J. I., Voigt, R. M., Shaikh, M. W., Engen, P. A., & Keshavarzian, A. (2022) · Microorganisms · doi:10.3390/microorganisms10101996 · Cited by 51 · see citing works
Innate Immune Responses by Respiratory Viruses, Including Rhinovirus, During Asthma Exacerbation
Nakagome, K., & Nagata, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.865973 · Cited by 49 · see citing works
Varshney, B., & Lal, S. K. (2011) · Biochemistry · doi:10.1021/bi200303r · Cited by 48 · see citing works
Pathogenesis and Management of Myocardial Injury in Coronavirus Disease 2019
Wei, Z., Geng, Y., Huang, J., & Qian, H. (2020) · European Journal of Heart Failure · doi:10.1002/ejhf.1967 · Cited by 44 · see citing works
Ray, P. R., Wangzhou, A., Ghneim, N., Yousuf, M. S., Paige, C. A., Tavares‐Ferreira, D., Mwirigi, J. M., Shiers, S. I., Sankaranarayanan, I., McFarland, A. J., et al. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.05.078 · Cited by 42 · see citing works
COVID-19, Angiotensin Receptor Blockers, and the Brain
Saavedra, J. M. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00861-y · Cited by 39 · see citing works
Beaudoin, C. A., Jamasb, A. R., Alsulami, A. F., Copoiu, L., van Tonder, A. J., Hala, S. M., Bannerman, B. P., Thomas, S. E., Vedithi, S. C., Torres, P. H. M., et al. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.06.041 · Cited by 36 · see citing works
Carbon dioxide and MAPK signalling: towards therapy for inflammation
Gałgańska, H., Jarmuszkiewicz, W., & Gałgański, Ł. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01306-x · Cited by 38 · see citing works
The Contribution of Endothelial Dysfunction in Systemic Injury Subsequent to SARS-Cov-2 Infection
Maiuolo, J., Mollace, R., Gliozzi, M., Musolino, V., Carresi, C., Paone, S., Scicchitano, M., Macrì, R., Nucera, S., Bosco, F., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239309 · Cited by 37 · see citing works
Transcriptional Regulation of Chemokine Expression in Ovarian Cancer
Singha, B., Gatla, H. R., & Vancurova, I. (2015) · Biomolecules · doi:10.3390/biom5010223 · Cited by 35 · see citing works
SARS‐CoV‐2 spike spurs intestinal inflammation via VEGF production in enterocytes
Zeng, F., Li, Y., Deng, Z., He, J., Li, W., Wang, L., Lyu, T., Li, Z., Mei, C., Yang, M., et al. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202114844 · Cited by 35 · see citing works
Kryvenko, V., & Vadász, I. (2021) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00056.2021 · Cited by 34 · see citing works
Sarhan, N. M., Warda, A. E. A., Sarhan, R. M., Boshra, M. S., Mostafa‐Hedeab, G., ALruwaili, B. F., Ghareeb, H. S., Schaalan, M. F., & Fathy, S. (2022) · Medicina · doi:10.3390/medicina58101358 · Cited by 34 · see citing works
How can a traffic light properly work if it is always green? The paradox of CK2 signaling
Borgo, C., D’Amore, C., Cesaro, L., Sarno, S., Pinna, L. A., Ruzzene, M., & Salvi, M. (2021) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2021.1908951 · Cited by 32 · see citing works
Yiangou, L., Davis, R. P., & Mummery, C. L. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.11.003 · Cited by 30 · see citing works
Rehman, S. U., & Tabish, M. (2020) · Clinical Science · doi:10.1042/cs20200419 · Cited by 30 · see citing works
Files, D. C., Tacke, F., O’Sullivan, A., Dorr, P. K., Ferguson, W., & Powderly, W. G. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010547 · Cited by 29 · see citing works
Shin, J., Toyoda, S., Fukuhara, A., & Shimomura, I. (2022) · Biomedicines · doi:10.3390/biomedicines10081995 · Cited by 31 · see citing works
Vitamin D Deficiency: An Underestimated Factor in Sepsis?
Delrue, C., Speeckaert, R., Delanghe, J., & Speeckaert, M. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032924 · Cited by 30 · see citing works
Role of Chemokines in Rabies Pathogenesis and Protection
Niu, X., Wang, H., & Fu, Z. F. (2011) · Advances in virus research · doi:10.1016/b978-0-12-387040-7.00005-6 · Cited by 28 · see citing works
Src signaling involvement in Japanese encephalitis virus-induced cytokine production in microglia.
Chen, C.-J., Ou, Y., Chang, C.-Y., Pan, H.-C., Lin, S.-Y., Liao, S.-L., Raung, S., Chen, S.-Y., & Chang, C.-J. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.02.022 · Cited by 25 · see citing works
Self-citationCould SARS-CoV-2-induced lung injury be attenuated by vitamin D?
Xiao, D., Li, X., Su, X., Mu, D., & Qu, Y. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.10.059 · Cited by 27 · see citing works
Seeherman, S., & Suzuki, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041659 · Cited by 27 · see citing works
Zhou, L., Huntington, K. E., Zhang, S., Carlsen, L., So, E. Y., Parker, C., Şahin, İ., Safran, H. P., Kamle, S., Lee, C.-M., et al. (2020) · Oncotarget · doi:10.18632/oncotarget.27799 · Cited by 26 · see citing works
Angiotensin-converting enzyme 2, coronavirus disease 2019, and abdominal aortic aneurysms
Xu, B., Li, G., Guo, J., Ikezoe, T., Kasirajan, K., Zhao, S., & Dalman, R. L. (2021) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2021.01.051 · Cited by 26 · see citing works
Zhu, Q. C., Li, S., Yuan, L. X., Chen, R., Liu, D. X., & Fung, T. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115646 · Cited by 26 · see citing works
Inflammation, immunity and potential target therapy of SARS-COV-2: A total scale analysis review
Smail, S. W., Saeed, M., Alkasalias, T., Khudhur, Z. O., Younus, D. A., Rajab, M. F., Abdulahad, W. H., Hussain, H. I., Niaz, K., & Safdar, M. (2021) · Food and Chemical Toxicology · doi:10.1016/j.fct.2021.112087 · Cited by 25 · see citing works
Role of angiotensin-converting enzyme 2 in fine particulate matter-induced acute lung injury
Zhu, P., Zhang, W., Feng, F., Qin, L., Ji, W., Li, D., Liang, R., Zhang, Y., Wang, Y., Li, M., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.153964 · Cited by 25 · see citing works
Chemokine Regulation During Epidemic Coronavirus Infection
Majumdar, S., & Murphy, P. M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.600369 · Cited by 22 · see citing works
Sex-related immunity: could Toll-like receptors be the answer in acute inflammatory response?
Popotas, A., Casimir, G. J., Corazza, F., & Lefèvre, N. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1379754 · Cited by 24 · see citing works
Protein Kinase CK2 and SARS-CoV-2: An Expected Interplay Story
Meza, C. P. Q., & Ruzzene, M. (2023) · Kinases and Phosphatases · doi:10.3390/kinasesphosphatases1020009 · Cited by 22 · see citing works
Evidence Supports a Causal Model for Vitamin D in COVID-19 OutcomesPreprint
Davies, G., Garami, A., & Byers, J. (2020) · medRxiv · doi:10.1101/2020.05.01.20087965 · Cited by 21 · see citing works
SARS-CoV-2 Infection and Lung Cancer: Potential Therapeutic Modalities
Gupta, I., Rizeq, B. R., Elkord, E., Vranić, S., & Moustafa, A. A. (2020) · Cancers · doi:10.3390/cancers12082186 · Cited by 20 · see citing works
Potential treatments of COVID-19: Drug repurposing and therapeutic interventions
Raghav, P. K., Mann, Z., Ahluwalia, S. K., & Rajalingam, R. (2023) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2023.02.004 · Cited by 20 · see citing works
Ho, W., Shen, Z.-H., Chen, Y., Chen, T., Lü, X., & Fu, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30080 · Cited by 20 · see citing works
Drugs Modulating Renin-Angiotensin System in COVID-19 Treatment
Labandeira-García, J. L., Labandeira, C. M., Valenzuela, R., Pedrosa, M. A., Quijano, A., & Rodriguez-Perez, A. I. (2022) · Biomedicines · doi:10.3390/biomedicines10020502 · Cited by 20 · see citing works
Cytokine storm-calming property of the isoquinoline alkaloids in Coptis chinensis Franch
Lan, Y., Wang, H., Wu, J., & Meng, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.973587 · Cited by 19 · see citing works
Chemical evolution for taming the ‘pathogenic kinase’ PAK1
Maruta, H., & Kittaka, A. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.03.008 · Cited by 17 · see citing works
Evidence of a dysregulated vitamin D endocrine system in SARS-CoV-2 infected patient’s lung cells
George, B., Revikumar, A., Paul, A. M., Santhoshkumar, T. R., Pillai, M. R., & Kumar, R. (2021) · Scientific Reports · doi:10.1038/s41598-021-87703-z · Cited by 15 · see citing works
Maternal COVID-19 Vaccination and Its Potential Impact on Fetal and Neonatal Development
Karrow, N. A., Shandilya, U. K., Pelech, S., Wagter-Lesperance, L., McLeod, D., Bridle, B. W., & Mallard, B. A. (2021) · Vaccines · doi:10.3390/vaccines9111351 · Cited by 15 · see citing works
The key role of Calpain in COVID-19 as a therapeutic strategy
Juibari, A. D., Rezadoost, M. H., & Soleimani, M. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-01002-1 · Cited by 14 · see citing works
Zhou, L., Huntington, K. E., Zhang, S., Carlsen, L., So, E. Y., Parker, C., Şahin, İ., Safran, H. P., Kamle, S., Lee, C. M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.02.230839 · Cited by 13 · see citing works
Kahm, Y.-J., Jung, U., & Kim, R.-K. (2023) · Biomedicines · doi:10.3390/biomedicines11051462 · Cited by 12 · see citing works
Basu, S., Chakravarty, D., Bhattacharyya, D., Saha, P., & Patra, H. K. (2021) · Journal of Molecular Modeling · doi:10.1007/s00894-021-04779-0 · Cited by 13 · see citing works
SARS-CoV-2 Spike Protein and Lung Vascular Cells
Suresh, S. J., & Suzuki, Y. (2020) · Journal of Respiration · doi:10.3390/jor1010004 · Cited by 12 · see citing works
Basu, A., Penumutchu, S. R., Nguyen, K., Mbonye, U. R., Tolbert, B. S., Karn, J., Komar, A. A., & Mazumder, B. (2021) · Journal of Virology · doi:10.1128/jvi.01678-21 · Cited by 12 · see citing works
Al-Hindawi, A., AlDallal, U., Waly, Y. M., Hussain, M., Shelig, M., ElMitwalli, O. S., Deen, G. R., & Henari, F. Z. (2022) · Nanomaterials · doi:10.3390/nano12203550 · Cited by 12 · see citing works
Curcumin, an Inhibitor of PAK1, Potential Treatment for COVID-19
Nemati, M., Asl, E. R., Pouya, F. D., & Rasmi, Y. (2020) · Journal of Infectiology · doi:10.29245/2689-9981/2020/2.1160 · Cited by 10 · see citing works
Why does COVID‐19 pathology have several clinical forms?
Aliabadi, F., Ajami, M., & Pazoki–Toroudi, H. (2020) · BioEssays · doi:10.1002/bies.202000198 · Cited by 10 · see citing works
A pathway map of signaling events triggered upon SARS-CoV infection
Parthasarathi, K. T. S., Munjal, N. S., Dey, G., Kumar, A., Pandey, A., Balakrishnan, L., & Sharma, J. N. (2021) · Journal of Cell Communication and Signaling · doi:10.1007/s12079-021-00642-2 · Cited by 10 · see citing works
Shandilya, U. K., Sharma, A., Naylor, D., Cánovas, Á., Mallard, B. A., & Karrow, N. A. (2023) · Animals · doi:10.3390/ani13030508 · Cited by 10 · see citing works
Cérbulo‐Vázquez, A., García-Espinosa, M., Briones‐Garduño, J. C., Arriaga‐Pizano, L., Ferat-Osorio, E. A., Zavala-Barrios, B., Cabrera‐Rivera, G. L., Miranda‐Cruz, P. E., la Rosa, M. T. G.-D., Prieto‐Chávez, J. L., et al. (2022) · PLoS ONE · doi:10.1371/journal.pone.0264566 · Cited by 8 · see citing works
Zheng, W., Wang, T., Wu, P., Yan, Q., Liu, C., Wu, H. M., Zhan, S., Liu, X., Jiang, Y., & Zhuang, H. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.718874 · Cited by 8 · see citing works
Self-citationHigh-Performance Graphene-Modified Sensing Chip for SARS-CoV-2 Detection
Sharma, P. K., Mostafavi, E., Kim, N., Webster, T. J., & Kaushik, A. K. (2023) · Journal of Visualized Experiments · doi:10.3791/64730 · Cited by 7 · see citing works
Arslan, İ. (2023) · Natural Product Research · doi:10.1080/14786419.2023.2254454 · Cited by 7 · see citing works
Severe acute respiratory syndrome (SARS)
Beltz, L. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-98809-4.00004-8 · Cited by 7 · see citing works
Ferreira, I. R. S., Justino, I. A., Júnior, R. B. M., de Souza, M. G. M., de Lima, T. M., Pinheiro, A. M. D. F., Arruda, E., Bastos, J. K., & Marcato, P. D. (2025) · Scientific Reports · doi:10.1038/s41598-025-05683-w · Cited by 6 · see citing works
Plant polysaccharides with anti-lung injury effects as a potential therapeutic strategy for COVID-19
Huang, P., Zhang, J., Duan, W., Jiao, J., Leng, A., & Qu, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.982893 · Cited by 6 · see citing works
Synthesis and evaluation of chemical linchpins for highly selective CK2α targeting
Greco, F., Krämer, A., Wahl, L. M., Elson, L., Ehret, T. A. L., Gerninghaus, J., Möckel, J., Müller, S., Hanke, T., & Knapp, S. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.116672 · Cited by 6 · see citing works
Wang, X., Yang, G., Wang, Q., Zhao, Y., Ding, K., Ji, C., Shi, Z., Li, H., Li, Y., & Li, S. (2022) · Disease Markers · doi:10.1155/2022/8602068 · Cited by 6 · see citing works
Ontological Analysis of Coronavirus Associated Human Genes at the COVID-19 Disease Portal
Wang, S., Brodie, K. C., Pons, J. D., Demos, W., Gibson, A. C., Hayman, G. T., Hill, M. L., Kaldunski, M. L., Lamers, L., Laulederkind, S. J. F., et al. (2022) · Genes · doi:10.3390/genes13122304 · Cited by 5 · see citing works
SARS-CoV-2 NSP14 induces AP-1 transcriptional activity via its interaction with MEK
Li, W., Wang, Y., Peng, Q., Shi, Y., Wan, P., Yao, Y., Bai, T., Ma, Y., Shu, X., Liu, Y., et al. (2024) · Molecular Immunology · doi:10.1016/j.molimm.2024.09.001 · Cited by 5 · see citing works
SARS‐CoV ‐2 spike protein induces endothelial dysfunction in 3D engineered vascular networks
Stern, B., Monteleone, P. P., & Zoldan, J. (2023) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37543 · Cited by 5 · see citing works
Gu, S., Chen, Z., Meng, X., Liu, G., He, X., Huang, L., Wu, L., Gong, J., Chen, D., Xue, B., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03875-y · Cited by 5 · see citing works
SARS-CoV2 and Anti-COVID-19 mRNA Vaccines: Is There a Plausible Mechanistic Link with Cancer?
Isidoro, C. (2025) · Cancers · doi:10.3390/cancers17233867 · Cited by 4 · see citing works
Relationship Between COVID-19 and Angiotensin-Converting Enzyme 2: A Scoping Review
Asma, S., Vahedian‐Azimi, A., Faizi, F., Rahimi‐Bashar, F., Shahriary, A., Galeh, H. E. G., Nehrir, B., Guest, P. C., & Sahebkar, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-59261-5_5 · Cited by 4 · see citing works
Miltner, N., Linkner, T. R., Ambrus, V., Al-Muffti, A. S., Ahmad, H., Mótyán, J. A., Benkő, S., Tőzsér, J., & Mahdi, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.999233 · Cited by 3 · see citing works
Asih, S. C., Irdiani, R., Sahlan, M., & Nasikin, M. (2021) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2021.v13s2.08 · Cited by 3 · see citing works
Mitogen-activated protein kinases are carbon dioxide receptors in plantsPreprint
Gałgańska, H., & Gałgański, Ł. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.09.086116 · Cited by 3 · see citing works
- Authors
- Chen, I.-Y., Chang, S. C., Wu, H.-Y., Yu, T.-C., Wei, W.-C., Lin, S., Chien, C.-L., & Chang, M.-F.
- Affiliations
- Institute of Biochemistry and Molecular Biology
- Institute of Microbiology
- Center for Optoelectronic Biomedicine
- National Taiwan University (TW)
- Corresponding author
- Chang, Shin C.
- Chang, Ming-Fu
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2010-08
- Volume
- 84
- Issue
- 15
- Pages
- 7703-7712
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC2897593
- OpenAlex
- W2096549714
- Cited by
- 141
- References
- 45
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 6 · 2023: 12 · 2022: 22 · 2021: 30 · 2020: 42 · 2019: 1 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council
- Academia Sinica
- National Taiwan University
- National Cancer Institute
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Keywords
- SARS-CoV, ACE2 receptor, spike protein, MCP-1, ERK signaling, AP-1, RAS/RAF pathway, casein kinase 2, pulmonary fibrosis, A549 cells, SARS pathogenesis
- MeSH terms
- Angiotensin-Converting Enzyme 2, Cell Line, Enzyme-Linked Immunosorbent Assay, Epithelial Cells, Humans, Peptidyl-Dipeptidase A, Membrane Glycoproteins, Viral Envelope Proteins, Signal Transduction, Up-Regulation, Chemokine CCL2, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Severe acute respiratory syndrome-related coronavirus, Spike Glycoprotein, Coronavirus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
