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Neuropilin-1 Is Involved in Human T-Cell Lymphotropic Virus Type 1 Entry
Abstract
Human T-cell lymphotropic virus type 1 (HTLV-1) is transmitted through a viral synapse and enters target cells via interaction with the glucose transporter GLUT1. Here, we show that Neuropilin-1 (NRP1), the receptor for semaphorin-3A and VEGF-A165 and a member of the immune synapse, is also a physical and functional partner of HTLV-1 envelope (Env) proteins. HTLV-1 Env and NRP1 complexes are formed in cotransfected cells, and endogenous NRP1 contributes to the binding of HTLV-1 Env to target cells. NRP1 overexpression increases HTLV-1 Env-dependent syncytium formation. Moreover, overexpression of NRP1 increases both HTLV-1 and HTLV-2 Env-dependent infection, whereas down-regulation of endogenous NRP1 has the opposite effect. Finally, overexpressed GLUT1, NRP1, and Env form ternary complexes in transfected cells, and endogenous NRP1 and GLUT1 colocalize in membrane junctions formed between uninfected and HTLV-1-infected T cells. These data show that NRP1 is involved in HTLV-1 and HTLV-2 entry, suggesting that the HTLV receptor has a multicomponent nature.
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Cited by
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity
Cantuti-Castelvetri, L., Ojha, R., Pedro, L. D., Djannatian, M., Franz, J., Kuivanen, S., van der Meer, F., Kallio, K., Kaya, T., Anastasina, M., et al. (2020) · Science · doi:10.1126/science.abd2985 · Cited by 1,925
Gillet, N., Florins, A., Boxus, M., Burteau, C., Nigro, A., Vandermeers, F., Balon, H., Bouzar, A.-B., Defoiche, J., Burny, A., et al. (2007) · Retrovirology · doi:10.1186/1742-4690-4-18 · Cited by 398
Pais-Correia, A.-M., Sachse, M., Guadagnini, S., Robbiati, V., Lasserre, R., Gessain, A., Gout, O., Alcover, A., & Thoulouze, M.-I. (2010) · Nature Medicine · doi:10.1038/nm.2065 · Cited by 344
Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4+ T cells
Jones, K. S., Petrow-Sadowski, C., Huang, Y. K., Bertolette, D. C., & Ruscetti, F. W. (2008) · Nature Medicine · doi:10.1038/nm1745 · Cited by 284
Prud’homme, G. J., & Glinka, Y. (2012) · Oncotarget · doi:10.18632/oncotarget.626 · Cited by 275
Metadata
- Authors
- Ghez, D., Lepelletier, Y., Lambert, S., Fourneau, J.-M., Blot, V., Janvier, S., Arnulf, B., van Endert, P. M., Heveker, N., Pique, C., & Hermine, O.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2006-07-15
- Volume
- 80
- Issue
- 14
- Pages
- 6844-6854
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2144992527
- Cited by
- 209
- References
- 0
- FWCI
- 3.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ghez, D., Lepelletier, Y., Lambert, S., Fourneau, J.-M., Blot, V., Janvier, S., Arnulf, B., van Endert, P. M., Heveker, N., Pique, C., & Hermine, O. (2006). Neuropilin-1 Is Involved in Human T-Cell Lymphotropic Virus Type 1 Entry. Journal of Virology. https://doi.org/10.1128/jvi.02719-05
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