Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity
Open accessPublished version of a preprint
Abstract
Another host factor for SARS-CoV-2: Virus-host interactions determine cellular entry and spreading in tissues. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the earlier SARS-CoV use angiotensin-converting enzyme 2 (ACE2) as a receptor; however, their tissue tropism differs, raising the possibility that additional host factors are involved. The spike protein of SARS-CoV-2 contains a cleavage site for the protease furin that is absent from SARS-CoV (see the Perspective by Kielian). Cantuti-Castelvetri et al. now show that neuropilin-1 (NRP1), which is known to bind furin-cleaved substrates, potentiates SARS-CoV-2 infectivity. NRP1 is abundantly expressed in the respiratory and olfactory epithelium, with highest expression in endothelial and epithelial cells. Daly et al. found that the furin-cleaved S1 fragment of the spike protein binds directly to cell surface NRP1 and blocking this interaction with a small-molecule inhibitor or monoclonal antibodies reduced viral infection in cell culture. Understanding the role of NRP1 in SARS-CoV-2 infection may suggest potential targets for future antiviral therapeutics. Science , this issue p. 856 , p. 861 ; see also p. 765
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Neuropilin1 (NRP1) is an important cofactor for SARS-CoV-2 entry, particularly in cells with low ACE2 expression.
“Most recently, Neuropilin1 (NRP1) was identified as an important cofactor for entry, particularly in cells with low level ACE2 expression (Cantuti-Castelvetri et al., 2020).”
From COVID-19 and the human innate immune system (2021) · cites this paper as Cantuti-Castelvetri et al., 2020
Mesenchymal cells across all ages and ventricles expressed Ace2, cathepsins (Ctsl and Ctsb), and Neuropilin-1 (NRP1).
“Mesenchymal cells across all ages and ventricles expressed Ace2 (Angiotensin I converting enzyme 2; Figure 4J,S4J), the SARS-CoV-2 receptor, and other known and putative accessory components, including cathepsins (Ctsl and Ctsb (Muus et al., 2020)) and Neuropilin-1 (NRP1 (Cantuti-Castelvetri et al., 2020)) (Figure 4J, S4J).”
From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Cantuti-Castelvetri et al., 2020
NRP1 protein expression was validated in mesenchymal cells.
“We also validated the expression of NRP1 protein, an effector of SARS-CoV-2 cell entry and infectivity, in mesenchymal cells (Cantuti-Castelvetri et al., 2020) (Figure 4M).”
From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Cantuti-Castelvetri et al., 2020
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548 · see citing works
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041 · see citing works
A novel coronavirus from patients with pneumonia in China, 2019
Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Huang, B., Shi, W., Lu, R., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2001017 · Cited by 28,244 · see citing works
A pneumonia outbreak associated with a new coronavirus of probable bat origin
Zhou, P., Yang, X.-L., Wang, X.-G., Hu, B., Zhang, L., Zhang, W., Si, H.-R., Zhu, Y., Li, B., Huang, C.-L., et al. (2020) · Nature · doi:10.1038/s41586-020-2012-7 · Cited by 21,969 · see citing works
Hoffmann, M., Kleine-Weber, H., Schroeder, S., Krüger, N., Herrler, T., Erichsen, S., Schiergens, T. S., Herrler, G., Wu, N.-H., Nitsche, A., et al. (2020) · Cell · doi:10.1016/j.cell.2020.02.052 · Cited by 20,286 · see citing works
Comprehensive Integration of Single-Cell Data
Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453 · see citing works
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation
Wrapp, D., Wang, N., Corbett, K. S., Goldsmith, J. A., Hsieh, C.-L., Abiona, O., Graham, B. S., & McLellan, J. S. (2020) · Science · doi:10.1126/science.abb2507 · Cited by 8,897 · see citing works
Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein
Walls, A. C., Park, Y.-J., Tortorici, M. A., Wall, A., McGuire, A. T., & Veesler, D. (2020) · doi:10.1101/2020.02.19.956581 · Cited by 8,586 · see citing works
Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR
Corman, V. M., Landt, O., Kaiser, M., Molenkamp, R., Meijer, A., Chu, D. K. W., Bleicker, T., Brünink, S., Schneider, J. A., Schmidt, M. L., et al. (2020) · Eurosurveillance · doi:10.2807/1560-7917.es.2020.25.3.2000045 · Cited by 7,266 · see citing works
Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China
Mao, L., Jin, H., Wang, M., Hu, Y., Chen, S., He, Q., Chang, J., Hong, C., Zhou, Y., Wang, D., et al. (2020) · JAMA Neurology · doi:10.1001/jamaneurol.2020.1127 · Cited by 7,166 · see citing works
Virological assessment of hospitalized patients with COVID-2019
Wölfel, R., Corman, V. M., Guggemos, W., Seilmaier, M., Zange, S., Müller, M. A., Niemeyer, D., Jones, T. C., Vollmar, P., Rothe, C., et al. (2020) · Nature · doi:10.1038/s41586-020-2196-x · Cited by 6,661 · see citing works
ImageJ2: ImageJ for the next generation of scientific image data
Rueden, C., Schindelin, J., Hiner, M., DeZonia, B. E., Walter, A., Arena, E. T., & Eliceiri, K. W. (2017) · BMC Bioinformatics · doi:10.1186/s12859-017-1934-z · Cited by 5,895 · see citing works
Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19
Ackermann, M., Verleden, S. E., Kuehnel, M., Haverich, A., Welte, T., Laenger, F., Vanstapel, A., Werlein, C., Stark, H., Tzankov, A., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa2015432 · Cited by 5,613 · see citing works
Identification of a novel coronavirus in patients with severe acute respiratory syndrome
Drosten, C., Günther, S., Preiser, W., van der Werf, S., Brodt, H.-R., Becker, S., Rabenau, H., Panning, M., Kolesnikova, L., Fouchier, R. A. M., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030747 · Cited by 4,574 · see citing works
Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?
Fang, L., Karakiulakis, G., & Roth, M. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30116-8 · Cited by 2,947 · see citing works
A subcellular map of the human proteome
Thul, P. J., Åkesson, L., Wiking, M., Mahdessian, D., Geladaki, A., Ait Blal, H., Alm, T., Asplund, A., Björk, L., Breckels, L. M., et al. (2017) · Science · doi:10.1126/science.aal3321 · Cited by 2,813 · see citing works
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
Liao, M., Liu, Y., Yuan, J., Wen, Y., Xu, G., Zhao, J., Cheng, L., Li, J., Wang, X., Wang, F., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0901-9 · Cited by 2,614 · see citing works
Hoffmann, M., Kleine-Weber, H., & Pöhlmann, S. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.04.022 · Cited by 1,852 · see citing works
Multiorgan and Renal Tropism of SARS-CoV-2
Puelles, V. G., Lütgehetmann, M., Lindenmeyer, M. T., Sperhake, J. P., Wong, M. N., Allweiss, L., Chilla, S., Heinemann, A., Wanner, N., Liu, S., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmc2011400 · Cited by 1,775 · see citing works
Coutard, B., Valle, C., de Lamballerie, X. N., Canard, B., Seidah, N. G., & Decroly, É. (2020) · Antiviral Research · doi:10.1016/j.antiviral.2020.104742 · Cited by 1,685 · see citing works
Wilm, A., Aw, P. P. K., Bertrand, D., Yeo, G. H. T., Ong, S. H., Wong, C. H., Khor, C. C., Petric, R., Hibberd, M. L., & Nagarajan, N. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks918 · Cited by 1,338 · see citing works
Quick, J., Grubaugh, N. D., Pullan, S. T., Claro, I. M., Smith, A. D., Gangavarapu, K., Oliveira, G., Robles-Sikisaka, R., Rogers, T. F., Beutler, N. A., et al. (2017) · Nature Protocols · doi:10.1038/nprot.2017.066 · Cited by 1,190 · see citing works
Construction of a human cell landscape at single-cell level
Han, X., Zhou, Z., Fei, L., Sun, H., Wang, R., Chen, Y., Chen, H., Wang, J., Tang, H., Ge, W., et al. (2020) · Nature · doi:10.1038/s41586-020-2157-4 · Cited by 1,087 · see citing works
Mercer, J., Schelhaas, M., & Helenius, A. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060208-104626 · Cited by 1,057 · see citing works
Self-citationThe protein expression profile of ACE2 in human tissues
Hikmet, F., Méar, L., Edvinsson, Å., Micke, P., Uhlén, M., & Lindskog, C. (2020) · Molecular Systems Biology · doi:10.15252/msb.20209610 · Cited by 1,016 · see citing works
C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration
Teesalu, T., Sugahara, K. N., Kotamraju, V. R., & Ruoslahti, E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908201106 · Cited by 812 · see citing works
Self-citationThe single-cell transcriptomic landscape of early human diabetic nephropathy
Wilson, P. C., Wu, H., Kirita, Y., Uchimura, K., Ledru, N., Rennke, H. G., Welling, P. A., Waikar, S. S., & Humphreys, B. D. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908706116 · Cited by 544 · see citing works
VEGF-A and the Induction of Pathological Angiogenesis
Nagy, J. A., Dvořàk, A. M., & Dvorak, H. F. (2007) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.2.010506.134925 · Cited by 472 · see citing works
Davidson, A. D., Williamson, M. K., Lewis, S., Shoemark, D., Carroll, M. W., Heesom, K. J., Zambon, M., Ellis, J., Lewis, P. A., Hiscox, J. A., et al. (2020) · Genome Medicine · doi:10.1186/s13073-020-00763-0 · Cited by 457 · see citing works
COVID-19 and the Chemical Senses: Supporting Players Take Center Stage
Cooper, K. W., Brann, D. H., Farruggia, M. C., Bhutani, S., Pellegrino, R., Tsukahara, T., Weinreb, C., Joseph, P. V., Larson, E. D., Parma, V., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.032 · Cited by 335 · see citing works
Goldberg, I., Allan, C., Burel, J., Creager, D. A., Falconi, A., Hochheiser, H., Johnston, J., Mellen, J., Sorger, P. K., & Swedlow, J. R. (2005) · Genome biology · doi:10.1186/gb-2005-6-5-r47 · Cited by 316 · see citing works
Single-cell analysis of olfactory neurogenesis and differentiation in adult humans
Durante, M. A., Kurtenbach, S., Sargi, Z. B., Harbour, J. W., Choi, R., Kurtenbach, S., Goss, G. M., Matsunami, H., & Goldstein, B. J. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0587-9 · Cited by 254 · see citing works
An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor
Martinez-Martín, N., Marcandalli, J., Huang, C., Arthur, C. P., Perotti, M., Foglierini, M., Ho, H., Dosey, A. M., Shriver, S. K., Payandeh, J., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.028 · Cited by 229 · see citing works
Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells
Wang, H., Zhang, H., Zhang, J., Li, Y., Zhao, B., Feng, G., Du, Y., Xiong, D., Zhong, Q., Liu, W.-L., et al. (2015) · Nature Communications · doi:10.1038/ncomms7240 · Cited by 217 · see citing works
Neuropilin-1 Is Involved in Human T-Cell Lymphotropic Virus Type 1 Entry
Ghez, D., Lepelletier, Y., Lambert, S., Fourneau, J., Blot, V., Janvier, S., Arnulf, B., Endert, P. V., Heveker, N., Pique, C., et al. (2006) · Journal of Virology · doi:10.1128/jvi.02719-05 · Cited by 211 · see citing works
How does SARS-CoV-2 cause COVID-19?
Matheson, N. J., & Lehner, P. J. (2020) · Science · doi:10.1126/science.abc6156 · Cited by 205 · see citing works
An endocytosis pathway initiated through neuropilin-1 and regulated by nutrient availability
Pang, H., Braun, G. B., Friman, T., Aza‐Blanc, P., Ruidíaz, M. E., Sugahara, K. N., Teesalu, T., & Ruoslahti, E. I. (2014) · Nature Communications · doi:10.1038/ncomms5904 · Cited by 196 · see citing works
Self-citationEtchable plasmonic nanoparticle probes to image and quantify cellular internalization
Braun, G. B., Friman, T., Pang, H. B., Pallaoro, A., de Mendoza, T. H., Willmore, A.-M. A., Kotamraju, V. R., Mann, A. P., She, Z. G., Sugahara, K. N., et al. (2014) · Nature Materials · doi:10.1038/nmat3982 · Cited by 174 · see citing works
Self-citationFunctional analysis of potential cleavage sites in the MERS-coronavirus spike protein
Kleine‐Weber, H., Elzayat, M. T., Hoffmann, M., & Pöhlmann, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-34859-w · Cited by 159 · see citing works
Neuropilin Regulation of Angiogenesis, Arteriogenesis, and Vascular Permeability
Plein, A., Fantin, A., & Ruhrberg, C. (2014) · Microcirculation · doi:10.1111/micc.12124 · Cited by 125 · see citing works
NRP2 and CD63 Are Host Factors for Lujo Virus Cell Entry
Raaben, M., Jae, L. T., Herbert, A. S., Kuehne, A. I., Stubbs, S. H., Chou, Y., Blomen, V. A., Kirchhausen, T. L., Dye, J. M., Brummelkamp, T. R., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.10.002 · Cited by 122 · see citing works
A Novel Activation Mechanism of Avian Influenza Virus H9N2 by Furin
Tse, L. V., Hamilton, A. M., Friling, T., & Whittaker, G. R. (2013) · Journal of Virology · doi:10.1128/jvi.02648-13 · Cited by 84 · see citing works
Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epitheliumPreprint
Ravindra, N. G., Alfajaro, M. M., Gasque, V., Habet, V., Wei, J., Filler, R. B., Huston, N. C., Wan, H., Szigeti-Buck, K., Wang, B., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.06.081695 · Cited by 77 · see citing works
AL‐SHAMMA, H. A., & Vries, G. J. D. (1996) · Journal of Neurobiology · doi:10.1002/(sici)1097-4695(199601)29:1 · Cited by 45 · see citing works
Dorner, B. G., Steinbach, S., Hüser, M. B., Kroczek, R. A., & Scheffold, A. (2003) · Journal of Immunological Methods · doi:10.1016/s0022-1759(02)00498-2 · Cited by 32 · see citing works
Liao, K., Sikkema, D. J., Wang, C., & Lee, T. N. (2013) · Journal of Immunological Methods · doi:10.1016/j.jim.2012.12.010 · Cited by 22 · see citing works
Ullah, I., Chung, K., Beloor, J., Lee, S., & Kumar, P. (2019) · Journal of Visualized Experiments · doi:10.3791/59201 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Coronavirus biology and replication: implications for SARS-CoV-2
V’kovski, P., Kratzel, A., Steiner, S., Stalder, H., & Thiel, V. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-020-00468-6 · Cited by 3,175 · see citing works
Mechanisms of SARS-CoV-2 entry into cells
Jackson, C. B., Farzan, M., Chen, B., & Choe, H. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00418-x · Cited by 3,083 · see citing works
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells
Wang, K., Chen, W., Zhang, Z., Deng, Y., Lian, J., Du, P. F., Wei, D., Yang, Z., Sun, X., Gong, L., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00426-x · Cited by 1,592 · see citing works
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity
Garcia-Beltran, W. F., Lam, E. C., St. Denis, K., Nitido, A. D., Garcia, Z. H., Hauser, B. M., Feldman, J., Pavlovic, M. N., Gregory, D. J., Poznansky, M. C., et al. (2021) · Cell · doi:10.1016/j.cell.2021.03.013 · Cited by 1,353 · see citing works
Neuroinvasion of SARS-CoV-2 in human and mouse brain
Song, E., Zhang, C., Israelow, B., Lu-Culligan, A., Prado, A. V., Skriabine, S., Lu, P., Weizman, O.-E., Liu, F., Dai, Y., et al. (2020) · doi:10.1101/2020.06.25.169946 · Cited by 1,064 · see citing works
N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2
McCallum, M., De Marco, A., Lempp, F. A., Tortorici, M. A., Pinto, D., Walls, A. C., Beltramello, M., Chen, A., Liu, Z., Zatta, F., et al. (2021) · Cell · doi:10.1016/j.cell.2021.03.028 · Cited by 901 · see citing works
Lamers, M. M., & Haagmans, B. L. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00713-0 · Cited by 986 · see citing works
COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas
Ren, X., Wen, W., Fan, X., Hou, W., Su, B., Cai, P., Li, J., Liu, Y., Tang, F., Zhang, F., et al. (2021) · Cell · doi:10.1016/j.cell.2021.01.053 · Cited by 865 · see citing works
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
Ng, K. W., Faulkner, N., Cornish, G. H., Rosa, A., Harvey, R., Hussain, S., Ulferts, R., Earl, C., Wrobel, A. G., Benton, D. J., et al. (2020) · Science · doi:10.1126/science.abe1107 · Cited by 886 · see citing works
Single-cell multi-omics analysis of the immune response in COVID-19
Cambridge Institute of Therapeutic Immunology and Infectious Disease-National Institute of Health Research (CITIID-NIHR) COVID-19 BioResource Collaboration, Stephenson, E., Reynolds, G., Botting, R. A., Calero-Nieto, F. J., Morgan, M. D., Tuong, Z. K., Bach, K., Sungnak, W., Worlock, K. B., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01329-2 · Cited by 742 · see citing works
COVID-19 and the human innate immune system
Schultze, J. L., & Aschenbrenner, A. C. (2021) · Cell · doi:10.1016/j.cell.2021.02.029 · Cited by 714 · see citing works
Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies
Lee, W. S., Wheatley, A. K., Kent, S. J., & DeKosky, B. J. (2020) · Nature Microbiology · doi:10.1038/s41564-020-00789-5 · Cited by 676 · see citing works
Effects of COVID-19 on the Nervous System
Iadecola, C., Anrather, J., & Kamel, H. (2020) · Cell · doi:10.1016/j.cell.2020.08.028 · Cited by 663 · see citing works
Dysregulation of brain and choroid plexus cell types in severe COVID-19
Yang, A. C., Kern, F., Losada, P. M., Agam, M. R., Maat, C. A., Schmartz, G. P., Fehlmann, T., Stein, J. A., Schaum, N., Lee, D. P., et al. (2021) · Nature · doi:10.1038/s41586-021-03710-0 · Cited by 620 · see citing works
Innate immunity: the first line of defense against SARS-CoV-2
Diamond, M., & Kanneganti, T. (2022) · Nature Immunology · doi:10.1038/s41590-021-01091-0 · Cited by 612 · see citing works
Stroke genetics informs drug discovery and risk prediction across ancestries
Mishra, A., Malik, R., Hachiya, T., Jürgenson, T., Namba, S., Posner, D. C., Kamanu, F., Koido, M., Grand, Q. L., Shi, M., et al. (2022) · Nature · doi:10.1038/s41586-022-05165-3 · Cited by 591 · see citing works
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis
Wendisch, D., Dietrich, O., Mari, T., von Stillfried, S., Ibarra, I. L., Mittermaier, M., Mache, C., Chua, R. L., Knoll, R., Timm, S., et al. (2021) · Cell · doi:10.1016/j.cell.2021.11.033 · Cited by 528 · see citing works
SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas
Müller, J. A., Groß, R. M., Conzelmann, C., Krüger, J., Merle, U., Steinhart, J., Weil, T., Koepke, L., Bozzo, C. P., Read, C., et al. (2021) · Nature Metabolism · doi:10.1038/s42255-021-00347-1 · Cited by 555 · see citing works
Pellegrini, L., Albecka, A., Mallery, D. L., Kellner, M. J., Paul, D., Carter, A. P., James, L. C., & Lancaster, M. A. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.10.001 · Cited by 546 · see citing works
The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
Osuchowski, M., Winkler, M., Skirecki, T., Cajander, S., Shankar-Hari, M., Lachmann, G., Monneret, G., Venet, F., Bauer, M., Brunkhorst, F., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00218-6 · Cited by 396 · see citing works
Self-citationde Melo, G. D., Lazarini, F., Levallois, S., Hautefort, C., Michel, V., Larrous, F., Vérillaud, B., Aparicio, C., Wagner, S., Gheusi, G., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abf8396 · Cited by 498 · see citing works
Wang, S., Qiu, Z., Hou, Y., Deng, X., Xu, W., Zheng, T., Wu, P., Xie, S., Bian, W., Zhang, C., et al. (2021) · Cell Research · doi:10.1038/s41422-020-00460-y · Cited by 486 · see citing works
SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis
Bayati, A., Kumar, R., Francis, V., & McPherson, P. S. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100306 · Cited by 499 · see citing works
Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity
García-Beltrán, W. F., Lam, E. C., Denis, K. S., Nitido, A. D., Garcia, Z. H., Hauser, B. M., Feldman, J. E., Pavlovic, M., Gregory, D. J., Poznansky, M. C., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.006 · Cited by 446 · see citing works
Jacob, F., Pather, S. R., Huang, W., Zhang, F., Wong, S. Z. H., Zhou, H., Cubitt, B., Fan, W., Chen, C. Z., Xu, M., et al. (2020) · Cell stem cell · doi:10.1016/j.stem.2020.09.016 · Cited by 430 · see citing works
Greene, C., Connolly, R., Brennan, D., Laffan, A., O’Keeffe, E., Zaporojan, L., O’Callaghan, J., Thomson, B., Connolly, E., Argue, R., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01576-9 · Cited by 429 · see citing works
The neurobiology of long COVID
Monje, M., & Iwasaki, A. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.006 · Cited by 415 · see citing works
A cellular and spatial map of the choroid plexus across brain ventricles and ages
Dani, N., Herbst, R. H., McCabe, C., Green, G. S., Kaiser, K., Head, J. P., Cui, J., Shipley, F. B., Jang, A., Dionne, D., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.003 · Cited by 388 · see citing works
Tackling COVID-19 with neutralizing monoclonal antibodies
Corti, D., Purcell, L. A., Snell, G., & Veesler, D. (2021) · Cell · doi:10.1016/j.cell.2021.05.005 · Cited by 375 · see citing works
Local and systemic responses to SARS-CoV-2 infection in children and adults
Yoshida, M., Worlock, K. B., Huang, N., Lindeboom, R. G. H., Butler, C. R., Kumasaka, N., Dominguez Conde, C., Mamanova, L., Bolt, L., Richardson, L., et al. (2022) · Nature · doi:10.1038/s41586-021-04345-x · Cited by 365 · see citing works
Khan, M., Yoo, S., Clijsters, M., Backaert, W., Vanstapel, A., Speleman, K., Lietaer, C., Choi, S.-M., Hether, T. D., Marcelis, L., et al. (2021) · Cell · doi:10.1016/j.cell.2021.10.027 · Cited by 332 · see citing works
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment
Wu, C.-T., Lidsky, P. V., Xiao, Y., Lee, I. T., Cheng, R., Nakayama, T., Jiang, S., Demeter, J., Bevacqua, R. J., Chang, C., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.05.013 · Cited by 368 · see citing works
Suryadevara, N., Shrihari, S., Gilchuk, P., VanBlargan, L. A., Binshtein, E., Zost, S. J., Nargi, R. S., Sutton, R. E., Winkler, E. S., Chen, E. C., et al. (2021) · Cell · doi:10.1016/j.cell.2021.03.029 · Cited by 397 · see citing works
Lessons learned 1 year after SARS-CoV-2 emergence leading to COVID-19 pandemic
To, K. K., Sridhar, S., Chiu, K. H., Hung, D. L. L., Li, X., Hung, I. F., Tam, A. R., Chung, T. W., Chan, J. F., Zhang, J., et al. (2021) · Emerging Microbes & Infections · doi:10.1080/22221751.2021.1898291 · Cited by 350 · see citing works
COVID-19 and the Chemical Senses: Supporting Players Take Center Stage
Cooper, K. W., Brann, D. H., Farruggia, M. C., Bhutani, S., Pellegrino, R., Tsukahara, T., Weinreb, C., Joseph, P. V., Larson, E. D., Parma, V., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.06.032 · Cited by 335 · see citing works
Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy
Zhang, Q., Xiang, R., Huo, S., Zhou, Y., Jiang, S., Wang, Q., & Yu, F. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00653-w · Cited by 341 · see citing works
CD209L/L-SIGN and CD209/DC-SIGN Act as Receptors for SARS-CoV-2
Amraei, R., Yin, W., Napoleon, M. A., Suder, E. L., Berrigan, J. L., Zhao, Q., Olejnik, J., Chandler, K. B., Xia, C., Feldman, J. E., et al. (2021) · ACS Central Science · doi:10.1021/acscentsci.0c01537 · Cited by 338 · see citing works
Schwabenland, M., Salié, H., Tanevski, J., Killmer, S., Lago, M. S., Schlaak, A. E., Mayer, L., Matschke, J., Püschel, K., Fitzek, A., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.06.002 · Cited by 323 · see citing works
Self-citationMorphological, cellular and molecular basis of brain infection in COVID-19 patients
Crunfli, F., Carregari, V. C., Veras, F. P., Vendramini, P. H., Valença, A. G. F., Antunes, A. S. L. M., Brandão-Teles, C., da Silva Zuccoli, G., Reis-de-Oliveira, G., Silva-Costa, L. C., et al. (2020) · doi:10.1101/2020.10.09.20207464 · Cited by 331 · see citing works
ACE2: Evidence of role as entry receptor for SARS-CoV-2 and implications in comorbidities
Cuervo, N. Z., & Grandvaux, N. (2020) · eLife · doi:10.7554/elife.61390 · Cited by 306 · see citing works
SARS-CoV-2 Variants, Vaccines, and Host Immunity
Mistry, P., Barmania, F., Mellet, J., Peta, K. T., Strydom, A., Viljoen, I. M., James, W., Gordon, S., & Pepper, M. S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.809244 · Cited by 293 · see citing works
Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies
Lempp, F. A., Soriaga, L. B., Montiel-Ruiz, M., Benigni, F., Noack, J., Park, Y., Bianchi, S., Walls, A. C., Bowen, J. E., Zhou, J., et al. (2021) · Nature · doi:10.1038/s41586-021-03925-1 · Cited by 292 · see citing works
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
Brevini, T., Maes, M., Webb, G. J., John, B. V., Fuchs, C. D., Buescher, G., Wang, L., Griffiths, C., Brown, M. L., Scott, W. E., et al. (2022) · Nature · doi:10.1038/s41586-022-05594-0 · Cited by 295 · see citing works
Neuroinvasion and Encephalitis Following Intranasal Inoculation of SARS-CoV-2 in K18-hACE2 Mice
Kumari, P., Rothan, H. A., Natekar, J. P., Stone, S., Pathak, H., Strate, P. G., Arora, K., Brinton, M. A., & Kumar, M. (2021) · Viruses · doi:10.3390/v13010132 · Cited by 296 · see citing works
Nasal ciliated cells are primary targets for SARS-CoV-2 replication in the early stage of COVID-19
Ahn, J. H., Kim, J., Hong, S. P., Choi, S. Y., Yang, M. J., Ju, Y. S., Kim, Y. T., Kim, H. M., Rahman, M. T., Chung, M. K., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148517 · Cited by 289 · see citing works
Trougakos, I., Stamatelopoulos, K., Terpos, E., Tsitsilonis, O., Aivalioti, E., Paraskevis, D., Kastritis, E., Pavlakis, G., & Dimopoulos, M. (2021) · Journal of Biomedical Sciences · doi:10.1186/s12929-020-00703-5 · Cited by 241 · see citing works
Li, N., Hui, H., Bray, B., Gonzalez, G. M., Zeller, M., Anderson, K. G., Knight, R. D., Smith, D. M., Wang, Y., Carlin, A. F., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109091 · Cited by 277 · see citing works
Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning
Drucker, D. J. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.01.016 · Cited by 272 · see citing works
COVID-19, Renin-Angiotensin System and Endothelial Dysfunction
Amraei, R., & Rahimi, N. (2020) · Cells · doi:10.3390/cells9071652 · Cited by 275 · see citing works
Monocytes and Macrophages in COVID-19
Knoll, R., Schultze, J. L., & Schulte-Schrepping, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.720109 · Cited by 269 · see citing works
Wenzel, J., Lampe, J., Müller‐Fielitz, H., Schuster, R., Zille, M., Müller, K., Krohn, M., Körbelin, J., Zhang, L., Özorhan, Ü., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00926-1 · Cited by 252 · see citing works
Self-citationGallo, O., Locatello, L. G., Mazzoni, A., Novelli, L., & Annunziato, F. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-00359-2 · Cited by 246 · see citing works
The Eukaryotic Linear Motif resource: 2022 release
Kumar, M., Michael, S., Alvarado-Valverde, J., Mészáros, B., Sámano-Sánchez, H., Zeke, A., Dobson, L., Lazar, T., Örd, M., Nagpal, A., et al. (2021) · Nucleic Acids Res. · doi:10.1093/nar/gkab975 · Cited by 227 · see citing works
COVID-19 and metabolic disease: mechanisms and clinical management
Steenblock, C., Schwarz, P. E. H., Ludwig, B., Linkermann, A., Zimmet, P., Kulebyakin, K. Y., Va, T., Markov, A. G., Lehnert, H., de Angelis, M. H., et al. (2021) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(21)00244-8 · Cited by 248 · see citing works
Hoffmann, M., Hofmann-Winkler, H., Krüger, N., Kempf, A., Nehlmeier, I., Graichen, L., Arora, P., Sidarovich, A., Moldenhauer, A.-S., Winkler, M. S., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109415 · Cited by 258 · see citing works
Self-citationFrere, J. J., Serafini, R. A., Pryce, K. D., Zazhytska, M., Oishi, K., Golynker, I., Panis, M., Zimering, J. H., Horiuchi, S., Hoagland, D. A., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abq3059 · Cited by 233 · see citing works
The blood-brain barrier is dysregulated in COVID-19 and serves as a CNS entry route for SARS-CoV-2
Krasemann, S., Haferkamp, U., Pfefferle, S., Woo, M. S., Heinrich, F., Schweizer, M., Appelt‐Menzel, A., Cubukova, A., Barenberg, J., Leu, J., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.12.011 · Cited by 231 · see citing works
Rebendenne, A., Valadão, A. L. C., Tauziet, M., Maarifi, G., Bonaventure, B., Planès, R., McKellar, J., Nisole, S., Arnaud‐Arnould, M., Moncorgé, O., et al. (2021) · Journal of Virology · doi:10.1128/jvi.02415-20 · Cited by 210 · see citing works
Innate immune sensing of coronavirus and viral evasion strategies
Kasuga, Y., Zhu, B., Jang, K., & Yoo, J. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00602-1 · Cited by 230 · see citing works
Cognitive impact of COVID-19: looking beyond the short term
Miners, J. S., Kehoe, P. G., & Love, S. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00744-w · Cited by 248 · see citing works
Cardiovascular Manifestations of COVID-19 Infection
Magadum, A., & Kishore, R. (2020) · Cells · doi:10.3390/cells9112508 · Cited by 224 · see citing works
Persistent Brainstem Dysfunction in Long-COVID: A Hypothesis
Yong, S. J. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00793 · Cited by 226 · see citing works
ApoE-Isoform-Dependent SARS-CoV-2 Neurotropism and Cellular Response
Wang, C., Zhang, M., Garcia, G., Tian, E., Cui, Q., Chen, X., Sun, G., Wang, J., Arumugaswami, V., & Shi, Y. (2021) · Cell stem cell · doi:10.1016/j.stem.2020.12.018 · Cited by 220 · see citing works
Schönrich, G., Raftery, M. J., & Samstag, Y. (2020) · Advances in Biological Regulation · doi:10.1016/j.jbior.2020.100741 · Cited by 221 · see citing works
Cellular host factors for SARS-CoV-2 infection
Baggen, J., Vanstreels, E., Jansen, S., & Daelemans, D. (2021) · Nature Microbiology · doi:10.1038/s41564-021-00958-0 · Cited by 209 · see citing works
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): a Systemic Infection
Synowiec, A., Szczepański, A., Barreto-Durán, E., Lie, L. K., & Pyrć, K. (2021) · Clinical Microbiology Reviews · doi:10.1128/cmr.00133-20 · Cited by 221 · see citing works
The glycosylation in SARS-CoV-2 and its receptor ACE2
Gong, Y., Qin, S., Dai, L., & Tian, Z. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00809-8 · Cited by 207 · see citing works
Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2
Gu, Y., Cao, J., Zhang, X., Gao, H., Wang, Y., Wang, J., He, J., Jiang, X., Zhang, J., Shen, G., et al. (2021) · Cell Research · doi:10.1038/s41422-021-00595-6 · Cited by 206 · see citing works
Zhou, Y., Liu, Y., Gupta, S., Paramo, M. I., Hou, Y., Mao, C., Luo, Y., Judd, J., Wierbowski, S. D., Bertolotti, M., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01474-0 · Cited by 203 · see citing works
Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19
Alon, R., Sportiello, M., Kozlovski, S., Kumar, A., Reilly, E. C., Zarbock, A., Garbi, N., & Topham, D. J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00470-2 · Cited by 197 · see citing works
Murgolo, N., Therien, A. G., Howell, B. J., Klein, D. J., Koeplinger, K. A., Lieberman, L. A., Adam, G. C., Flynn, J. A., McKenna, P. M., Swaminathan, G., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009225 · Cited by 189 · see citing works
SARS-CoV-2 infection induces beta cell transdifferentiation
Tang, X., Uhl, S. A., Zhang, T., Xue, D., Li, B., Vandana, J. J., Acklin, J. A., Bonnycastle, L. L., Narisu, N., Erdos, M. R., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.05.015 · Cited by 192 · see citing works
Porritt, R. A., Paschold, L., Rivas, M. N., Cheng, M. H., Yonker, L. M., Chandnani, H. K., Lopez, M., Simnica, D., Schultheiß, C., Santiskulvong, C., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci146614 · Cited by 186 · see citing works
Laurent, Q., Martinent, R., Lim, B., Pham, A., Kato, T., López‐Andarias, J., Sakai, N., & Matile, S. (2021) · JACS Au · doi:10.1021/jacsau.1c00128 · Cited by 191 · see citing works
Proteolytic activation of SARS‐CoV‐2 spike protein
Takeda, M. (2021) · Microbiology and Immunology · doi:10.1111/1348-0421.12945 · Cited by 183 · see citing works
IL-13 is a driver of COVID-19 severity
Donlan, A. N., Sutherland, T. E., Marie, C. S., Preißner, S., Bradley, B. T., Carpenter, R. M., Sturek, J. M., Ma, J. Z., Moreau, G. B., Donowitz, J. R., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.150107 · Cited by 182 · see citing works
Innate immunological pathways in COVID-19 pathogenesis
Paludan, S. R., & Mogensen, T. H. (2022) · Science Immunology · doi:10.1126/sciimmunol.abm5505 · Cited by 186 · see citing works
Endothelium Infection and Dysregulation by SARS-CoV-2: Evidence and Caveats in COVID-19
Bernard, I., Limonta, D., Mahal, L. K., & Hobman, T. C. (2020) · Viruses · doi:10.3390/v13010029 · Cited by 182 · see citing works
Viral infiltration of pancreatic islets in patients with COVID-19
Steenblock, C., Richter, S., Berger, I., Barovic, M., Schmid, J., Schubert, U., Jarzebska, N., von Mäßenhausen, A., Linkermann, A., Schürmann, A., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23886-3 · Cited by 181 · see citing works
Post-viral effects of COVID-19 in the olfactory system and their implications
Xydakis, M. S., Albers, M. W., Holbrook, E. H., Lyon, D. M., Shih, R., Frasnelli, J., Pagenstecher, A., Kupke, A., Enquist, L. W., & Perlman, S. M. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(21)00182-4 · Cited by 183 · see citing works
The role of Neuropilin-1 in COVID-19
Mayi, B. S., Leibowitz, J. A., Woods, A. T., Ammon, K. A., Liu, A. E., & Raja, A. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009153 · Cited by 179 · see citing works
Hoagland, D. A., Møller, R., Uhl, S. A., Oishi, K., Frere, J. J., Golynker, I., Horiuchi, S., Panis, M., Blanco-Melo, D., Sachs, D. M., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.01.017 · Cited by 170 · see citing works
The Mechanism and Consequences of SARS-CoV-2 Spike-Mediated Fusion and Syncytia Formation
Rajah, M. M., Bernier, A., Buchrieser, J., & Schwartz, O. (2021) · Journal of Molecular Biology · doi:10.1016/j.jmb.2021.167280 · Cited by 176 · see citing works
ACE2-independent infection of T lymphocytes by SARS-CoV-2
Shen, X.-R., Geng, R., Li, Q., Chen, Y., Li, S., Wang, Q. M., Min, J., Yang, Y. P., Li, B., Jiang, R.-D., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00919-x · Cited by 171 · see citing works
Carlos, A. J., Ha, D. P., Yeh, D., Krieken, R. V., Tseng, C.-C., Zhang, P., Gill, P. S., Machida, K., & Lee, A. S. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100759 · Cited by 172 · see citing works
Innate metabolic responses against viral infections
Palmer, C. S. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00652-3 · Cited by 158 · see citing works
Acute and chronic neurological disorders in COVID-19: potential mechanisms of disease
Balcom, E. F., Nath, A., & Power, C. (2021) · Brain · doi:10.1093/brain/awab302 · Cited by 161 · see citing works
Zhou, Y., Xu, J., Hou, Y., Leverenz, J. B., Kallianpur, A. R., Mehra, R., Liu, Y., Yu, H., Pieper, A. A., Jehi, L. E., et al. (2021) · Alzheimer s Research & Therapy · doi:10.1186/s13195-021-00850-3 · Cited by 161 · see citing works
Peng, R., Wu, L.-A., Wang, Q., Qi, J., & Gao, G. F. (2021) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2021.06.001 · Cited by 163 · see citing works
SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia
Moutal, A., Martin, L., Boinon, L., Gómez, K., Ran, D., Zhou, Y., Stratton, H. J., Cai, S., Luo, S., Gonzalez, K. B., et al. (2020) · Pain · doi:10.1097/j.pain.0000000000002097 · Cited by 160 · see citing works
The structural basis of accelerated host cell entry by SARS‐CoV‐2†
Seyran, M., Takayama, K., Uversky, V. N., Lundstrom, K. H., Palù, G., Sherchan, S. P., Attrish, D., Rezaei, N., Aljabali, A. A. A., Ghosh, S., et al. (2020) · FEBS Journal · doi:10.1111/febs.15651 · Cited by 159 · see citing works
Qiao, L., Liu, J., Zhao, S., Castro, M. F. G., Laurent-Rolle, M., Dong, J., Ran, X., Damani‐Yokota, P., Tang, H., Karakousi, T. R., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.05.006 · Cited by 152 · see citing works
Davies, J., Randeva, H. S., Chatha, K. K., Hall, M., Spandidos, D. A., Karteris, E., & Kyrou, I. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11510 · Cited by 159 · see citing works
What can we learn from brain autopsies in COVID-19?
Mukerji, S. S., & Solomon, I. H. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135528 · Cited by 156 · see citing works
TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry
Baggen, J., Jacquemyn, M., Persoons, L., Vanstreels, E., Pye, V. E., Wrobel, A. G., Calvaresi, V., Martin, S. R., Roustan, C., Cronin, N., et al. (2023) · Cell · doi:10.1016/j.cell.2023.06.005 · Cited by 153 · see citing works
Mykytyn, A. Z., Breugem, T. I., Riesebosch, S., Schipper, D., van den Doel, P. B., Rottier, R. J., Lamers, M. M., & Haagmans, B. L. (2021) · eLife · doi:10.7554/elife.64508 · Cited by 150 · see citing works
COVID ‐19: immunopathology, pathophysiological mechanisms, and treatment options
van Eijk, L. E., Binkhorst, M., Bourgonje, A. R., Offringa, A. K., Mulder, D. J., Bos, E. M., Kolundžić, N., Abdulle, A. E., van der Voort, P. H. J., Rikkert, M. G. M. O., et al. (2021) · The Journal of Pathology · doi:10.1002/path.5642 · Cited by 153 · see citing works
Schmitz, A., Weber, A., Bayin, M., Breuers, S., Fieberg, V., Famulok, M., & Mayer, G. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202100316 · Cited by 149 · see citing works
Human organoid models to study SARS-CoV-2 infection
Han, Y., Yang, L., Lacko, L. A., & Chen, S. (2022) · Nature Methods · doi:10.1038/s41592-022-01453-y · Cited by 150 · see citing works
A cohort autopsy study defines COVID-19 systemic pathogenesis
Yao, X.-H., Luo, T., Shi, Y., He, Z.-C., Tang, R., Zhang, P.-P., Cai, J., Zhou, X.-D., Jiang, D., Fei, X., et al. (2021) · Cell Research · doi:10.1038/s41422-021-00523-8 · Cited by 146 · see citing works
- Authors
- Cantuti-Castelvetri, L., Ojha, R., Pedro, L. D., Djannatian, M., Franz, J., Kuivanen, S., van der Meer, F., Kallio, K., Kaya, T., Anastasina, M., Smura, T., Levanov, L., Szirovicza, L., Tobi, A., Kallio-Kokko, H., Österlund, P., Joensuu, M., Meunier, F. A., Butcher, S. J., Winkler, M. S., Mollenhauer, B., Helenius, A., Gokce, O., Teesalu, T., Hepojoki, J., Vapalahti, O., Stadelmann, C., Balistreri, G., & Simons, M.
- Affiliations
- Institute of Neuronal Cell Biology, Technical University Munich, Munich, Germany.
- University of Helsinki (FI)
- German Center for Neurodegenerative Diseases (DE)
- Universitätsmedizin Göttingen (DE)
- Department of Neuropathology, University Medical Center Göttingen, Göttingen, Germany.
- Department of Virology, Medicum, University of Helsinki, Helsinki, Finland.
- University of Tartu (EE)
- Department of Virology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
- Finnish Institute for Health and Welfare (FI)
- The University of Queensland (AU)
- ETH Zurich (CH)
- Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
- University of Zurich (CH)
- Corresponding author
- Ojha, Ravi
- Pedro, Liliana D.
- Djannatian, Minou
- Franz, Jonas
- Kuivanen, Suvi
- Balistreri, Giuseppe
- Simons, Mikael
- ORCID
- Cantuti-Castelvetri, Ludovico
- Ojha, Ravi
- Pedro, Liliana D.
- Djannatian, Minou
- Franz, Jonas
- Kuivanen, Suvi
- van der Meer, Franziska
- Kallio, Katri
- Kaya, Tuğberk
- Anastasina, Maria
- Smura, Teemu
- Levanov, Lev
- Szirovicza, Leonora
- Tobi, Allan
- Österlund, Pamela
- Joensuu, Merja
- Meunier, Frédéric A.
- Butcher, Sarah J.
- Winkler, Martin Sebastian
- Mollenhauer, Brit
- Gokce, Ozgun
- Teesalu, Tambet
- Hepojoki, Jussi
- Vapalahti, Olli
- Stadelmann, Christine
- Balistreri, Giuseppe
- Simons, Mikael
- Venue
- Science
- Published
- 2020-11-13
- Volume
- 370
- Issue
- 6518
- Pages
- 856-860
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC7857391
- OpenAlex
- W3093867667
- Cited by
- 1,925
- References
- 47
- Citations by year
- 2026: 56 · 2025: 120 · 2024: 211 · 2023: 277 · 2022: 461 · 2021: 669 · 2020: 128 · 2018: 2
- FWCI
- 50.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Science (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion, cc-by)
- Työväentutkimus Vuosikirja (submittedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, other-oa)
- Funders
- ERC CoV
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 detection and testing
- Keywords
- neuropilin-1, SARS-CoV-2, viral entry, furin cleavage, spike protein, host factors, viral infectivity, monoclonal antibodies, small molecule inhibitors, antiviral agents, viral tropism, ACE2
- MeSH terms
- Protein Domains, Betacoronavirus, Host Microbial Interactions, Angiotensin-Converting Enzyme 2, COVID-19, SARS-CoV-2, Animals, Antibodies, Monoclonal, Female, Humans, Peptidyl-Dipeptidase A, Lung, Male, Mice, Inbred C57BL, Mutation, Olfactory Mucosa, Peptide Fragments, Pneumonia, Viral, Protein Binding, Serine Endopeptidases, Coronavirus Infections, Caco-2 Cells, Respiratory Mucosa, Neuropilin-1, Neuropilin-2, Mice, Virus Internalization, Metal Nanoparticles, HEK293 Cells, Pandemics, Spike Glycoprotein, Coronavirus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
