Quantitative aspects of passive immunity to respiratory syncytial virus infection in infant cotton rats
Open accessAbstract
The amount of passively acquired serum respiratory syncytial virus (RSV)-neutralizing antibodies required to protect the respiratory tract of cotton rats against infection was studied. Infant cotton rats were inoculated intraperitoneally with various dilutions of a single pool of sera derived from cotton rats convalescent from RSV infection. After 24 h, these animals were inoculated with RSV intranasally. Virus replication in the respiratory tract was suppressed in cotton rats which had a serum neutralizing antibody titer of 1:100 or greater. Resistance was greater in the lungs than in the nose. Complete or almost complete resistance in the lungs was observed in cotton rats with a serum neutralizing antibody titer of 1:380 or greater. The level of serum RSV-neutralizing antibodies required to confer significant resistance to infection in the cotton rat was similar to the level of maternally derived serum antibodies possessed by human infants less than 2 months of age, who as a group exhibit relative resistance to RSV disease compared with infants 2 to 6 months of age.
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The neutralization titers elicited by LNP/RNA are above the titer of 380 that correlates with protection in cotton rats and similar to passively acquired serum neutralizing titers that correlate with protection of human infants from severe RSV disease.
“The neutralization titers elicited by LNP/RNA are above the titer of 380 that correlates with protection in cotton rats (30) and similar to passively acquired serum neutralizing titers that correlate with protection of human infants from severe RSV disease (31,32).”
From Nonviral delivery of self-amplifying RNA vaccines (2012) · cites this paper as [30]
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References 12 · Cited by 245
- Authors
- Prince, G. A., Horswood, R. L., & Chanock, R. M.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1985-09
- Volume
- 55
- Issue
- 3
- Pages
- 517-520
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC254995
- OpenAlex
- W2104427618
- Cited by
- 245
- References
- 12
- Citations by year
- 2024: 4 · 2023: 4 · 2022: 6 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 10 · 2015: 8 · 2014: 8 · 2013: 5 · 2012: 5
- FWCI
- 7.76
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Keywords
- respiratory syncytial virus, passive immunity, antibody titers, Sigmodon hispidus, infant rats, pulmonary infection, nasal infection, maternal antibodies, infant immunology, viral replication
- MeSH terms
- Animals, Antibodies, Viral, Immune Sera, Immunization, Passive, Lung, Neutralization Tests, Nose, Respirovirus Infections, Respiratory Syncytial Viruses, Rats
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