Differences in cell-to-cell spread of pathogenic and apathogenic rabies virus in vivo and in vitro
Open accessAbstract
Pathogenic parental rabies virus and apathogenic variant virus were shown to differ in their ability to infect neurons in vivo and neuroblastoma cells in vitro. After intracerebral inoculation, the distribution of infected neurons in the brain was similar for both viruses, but the rate of spread throughout the brain, the number of infected neurons, and the degree of cellular necrosis were much lower in the case of apathogenic virus. After adsorption to mouse neuroblastoma cells, apathogenic virus was less rapidly internalized than pathogenic virus, and cell-to-cell spread of apathogenic variant virus was completely prevented by the addition of rabies virus-neutralizing antibody, whereas the spread of pathogenic virus was not affected.
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According to in vitro data, the rabies virus enters cells within 20 min after inoculation (Dietzschold et al, 1985).
“According to in vitro data, the virus enters cells within 20 min after inoculation (Dietzschold et al, 1985).”
From mRNA mediates passive vaccination against infectious agents, toxins, and tumors (2017) · cites this paper as Dietzschold et al, 1985
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Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases
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mRNA mediates passive vaccination against infectious agents, toxins, and tumors
Thran, M., Mukherjee, J., Pönisch, M., Fiedler, K., Thess, A., Mui, B. L., Hope, M. J., Tam, Y. K., Horscroft, N., Heidenreich, R., et al. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201707678 · Cited by 166 · see citing works
“According to in vitro data, the virus enters cells within 20 min after inoculation (Dietzschold et al, 1985).”
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- Authors
- Dietzschold, B., Wiktor, T. J., Trojanowski, J. Q., Macfarlan, R. I., Wunner, W. H., Torres-Anjel, M. J., & Koprowski, H.
- ORCID
- Trojanowski, J Q
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1985-10
- Volume
- 56
- Issue
- 1
- Pages
- 12-18
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC252462
- OpenAlex
- W1486290678
- Cited by
- 155
- References
- 19
- Citations by year
- 2026: 3 · 2025: 4 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 1 · 2017: 6 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 3
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI 18562, AI-09706)
- National Institute of Neurological Disorders and Stroke (NS-16723)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › Rabies epidemiology and control
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
- Keywords
- rabies virus, cell-to-cell transmission, neuroblastoma cells, neuronal infection, intracerebral injection, viral internalization, rabies virus neutralizing antibodies, brain infection, necrosis
- MeSH terms
- Animals, Cells, Cultured, Cerebellum, Cricetinae, Immunoenzyme Techniques, Neurons, Rabies virus, Receptors, Virus, Viral Proteins, Virus Replication, Mice
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