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Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff
Open accessAbstract
To delineate the function of adenovirus early region 4 (E4) gene products, we constructed a set of mutant viruses which carry defined lesions within this coding region. Deletion and insertion mutations within six of seven known E4 coding regions had no measurable effect on virus growth in cultured cells. A variant carrying a deletion within the last coding region (encoding a 34,000-molecular-weight polypeptide) was modestly defective, and a mutant lacking the majority of the E4 region was severely defective for growth. The phenotypes of the two defective mutants are similar and complex. Both display perturbations in DNA replication, translation of the E2A mRNA, accumulation of late viral mRNAs, and host cell shutoff.
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Cited by
Roth, J., Dobbelstein, M., Freedman, D. A., Shenk, T., & Levine, A. J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.2.554 · Cited by 610
Self-citationAdenovirus oncoproteins inactivate the Mre11–Rad50–NBS1 DNA repair complex
Stracker, T. H., Carson, C. T., & Weitzman, M. D. (2002) · Nature · doi:10.1038/nature00863 · Cited by 522
Syed, A., & Tainer, J. A. (2018) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-062917-012415 · Cited by 398
Blockage by Adenovirus E4orf6 of Transcriptional Activation by the p53 Tumor Suppressor
Dobner, T., Horikoshi, N., Rubenwolf, S., & Shenk, T. (1996) · Science · doi:10.1126/science.272.5267.1470 · Cited by 311
Self-citationRedundant control of adenovirus late gene expression by early region 4
Bridge, E., & Ketner, G. (1989) · Journal of Virology · doi:10.1128/jvi.63.2.631-638.1989 · Cited by 259
Metadata
- Authors
- Halbert, D. N., Cutt, J. R., & Shenk, T.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1985-10
- Volume
- 56
- Issue
- 1
- Pages
- 250-257
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2137745922
- Cited by
- 381
- References
- 0
- FWCI
- 6.31
- Type
- journal article
- Language
- en
- Open access
- green
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- Halbert, D. N., Cutt, J. R., & Shenk, T. (1985). Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff. Journal of Virology. https://doi.org/10.1128/jvi.56.1.250-257.1985
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