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CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity
Open accessAbstract
We have shown in a murine model system for acute, lethal cytomegalovirus (CMV) disease in the immunocompromised natural host that control of virus multiplication in tissues, protection from virus-caused tissue destruction, and survival are mediated by virus-specific CD8+ CD4-T lymphocytes. Protection from a lethal course of disease did not result in a rapid establishment of virus latency, but led to a long-lasting, persistent state of infection. The CD8- CD4+ subset of T lymphocytes was not effective by itself in controlling murine CMV (MCMV) multiplication in tissue or essential for the protective function of the CD8+ CD4- effector cells. The antiviral efficacy of the purified CD8+ CD4- subset was not impaired by preincubation with fibroblasts that presented viral structural antigens, but was significantly reduced after depletion of effector cells specific for the nonstructural immediate-early antigens of MCMV, which are specified by the first among a multitude of viral genes expressed during MCMV replication in permissive cells. Thus, MCMV disease provides the first example of a role for nonstructural herpesvirus immediate-early antigens in protective immunity.
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Cited by
Jonjić, S., Mutter, W., Weiland, F., Reddehase, M. J., & Koszinowski, U. H. (1989) · The Journal of experimental medicine · doi:10.1084/jem.169.4.1199 · Cited by 2,105
Self-citationWalter, E. A., Greenberg, P. D., Gilbert, M. J., Finch, R. J., Watanabe, K. S., Thomas, E. D., & Riddell, S. R. (1995) · New England Journal of Medicine · doi:10.1056/nejm199510193331603 · Cited by 1,771
Khan, N., Shariff, N., Cobbold, M., Bruton, R., Ainsworth, J. A., Sinclair, A. J., Nayak, L., & Moss, P. A. H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.4.1984 · Cited by 754
Einsele, H., Roosnek, E., Rufer, N., Sinzger, C., Riegler, S., Löffler, J., Grigoleit, U., Moris, A., Rammensee, H.-G., Kanz, L., et al. (2002) · Blood · doi:10.1182/blood.v99.11.3916 · Cited by 699
T cell responses to cytomegalovirus
Klenerman, P., & Oxenius, A. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.38 · Cited by 483
Metadata
- Authors
- Reddehase, M. J., Mutter, W., Münch, K., Bühring, H. J., & Koszinowski, U. H.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1987-10
- Volume
- 61
- Issue
- 10
- Pages
- 3102-3108
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1978037344
- Cited by
- 423
- References
- 0
- FWCI
- 15.61
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity. https://app.cochat.ai/papers/10.1128/jvi.61.10.3102-3108.1987
- The paper
- Reddehase, M. J., Mutter, W., Münch, K., Bühring, H. J., & Koszinowski, U. H. (1987). CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity. Journal of Virology. https://doi.org/10.1128/jvi.61.10.3102-3108.1987
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
