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The major human papillomavirus protein in cervical cancers is a cytoplasmic phosphoprotein
Abstract
In a previous study, the most abundant viral transcript in a human papillomavirus type 16-associated cervical cancer and in a cancer-derived cell line was characterized, and its translation product, the E7 protein, was identified (D. Smotkin and F. O. Wettstein, Proc. Natl. Acad. Sci. USA 68:4680-4684, 1986). Here we show that the E7 protein had a half life of about 1 h and was located in the soluble cytoplasmic fraction. The protein was phosphorylated at serine residues and exhibited a high heterogeneous sedimentation rate in nondenaturing glycerol gradients, suggesting an oligomer formation or association with cellular protein.
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“HPV-16 E7 was shown to be a cytoplasmic phosphoprotein as early as 1987 [72]; however, nuclear pools have also been reported [73,74,75,76]”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [72]
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Research works printed but not linked: 6
- [4]4. Duerst, M., L. Gissmann, H. Ikenberg, and H. zur Hausen. 1983. A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc. Natl. Acad. Sci. USA 80:3812–3815.
- [6]6. Grussenmeyer, T., K. H. Scheidtmann, M. A. Hutchinson, W. Eckhart, and G. Walter. 1985. Complexes of polyoma virus medium T antigen and cellular proteins. Proc. Natl. Acad. Sci. USA 82:7952–7954.
- [13]13. Schiller, J. T., W. C. Vass, and D. R. Lowy. 1984. Identification of a second transforming region in bovine papillomavirus DNA. Proc. Natl. Acad. Sci. USA 81:7880–7884.
- [18]18. Smotkin, D., and F. O. Wettstein. 1986. Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein. Proc. Natl. Acad. Sci. USA 83:4680–4684.
- [23]23. Yonemoto, W., M. Jarvis-Marar, J. S. Brugge, J. B. Bolen, and M. A. Israel. 1985. Tyrosine phosphorylation within the aminoterminal domain of pp60c-sre molecules associated with polyoma virus middle sized tumor antigen. Proc. Natl. Acad. Sci. USA 82:4568-4572.
- [22]22. Yang, Y.-C., H. Okayama, and P. M. Howley. 1985. Bovine papillomavirus contains multiple transforming genes. Proc. Natl. Acad. Sci. USA 82:1030–1034.
Cited by
The human papilloma virus-16 E7-oncoprotein is able to bind to the retinoblastoma gene product
Dyson, N., Howley, P. M., Münger, K., & Harlow, E. (1989) · Science · doi:10.1126/science.2537532 · Cited by 3,017
Basukala, O., & Banks, L. (2021) · Viruses · doi:10.3390/v13101892 · Cited by 137
Metadata
- Authors
- Smotkin, D., & Wettstein, F. O.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1987-05
- Volume
- 61
- Issue
- 5
- Pages
- 1686-1689
- ISSN
- 0022-538X
- 1098-5514
- Cited by
- 159
- References
- 0
- Language
- en
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