The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Human immunodeficiency virus neutralizing antibodies recognize several conserved domains on the envelope glycoproteins
Open accessAbstract
Serum neutralizing antibodies against the human immunodeficiency virus were frequently detected in infected individuals, and low or absent serum neutralizing titers correlated with poor prognosis. Multiple diverse human immunodeficiency virus isolates were found to exhibit similar susceptibility to neutralization by a panel of human seropositive sera, suggesting that neutralizing antibodies are largely directed against conserved viral domains. Furthermore, utilizing antisera raised against a library of synthetic env peptides, four regions which are important in the neutralization process have been identified within both human immunodeficiency virus envelope glycoproteins (gp41 and gp120). Three of these are in conserved domains and should be considered for inclusion in a candidate vaccine.
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Cites
Starcich, B. R., Hahn, B. H., Shaw, G. M., McNeely, P. D., Modrow, S., Wolf, H., Parks, E. S., Parks, W. P., Josephs, S. F., Gallo, R. C., et al. (1986) · Cell · doi:10.1016/0092-8674(86)90778-6 · Cited by 767
Cited by
Banda, N. K., Bernier, J., Kurahara, D. K., Kurrle, R., Haigwood, N., Sekaly, R. P., & Finkel, T. H. (1992) · The Journal of experimental medicine · doi:10.1084/jem.176.4.1099 · Cited by 668
Broadly Neutralizing Antibodies Elicited by the Hypervariable Neutralizing Determinant of HIV-1
Javaherian, K., Langlois, A. J., LaRosa, G. J., Profy, A. T., Bolognesi, D. P., Herlihy, W. C., Putney, S. D., & Matthews, T. J. (1990) · Science · doi:10.1126/science.1703322 · Cited by 353
Metadata
- Authors
- Ho, D. D., Sarngadharan, M. G., Hirsch, M. S., Schooley, R. T., Rota, T. R., Kennedy, R. C., Chanh, T. C., & Sato, V. L.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1987-06
- Volume
- 61
- Issue
- 6
- Pages
- 2024-2028
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1710012409
- Cited by
- 294
- References
- 1
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Ho, D. D., Sarngadharan, M. G., Hirsch, M. S., Schooley, R. T., Rota, T. R., Kennedy, R. C., Chanh, T. C., & Sato, V. L. (1987). Human immunodeficiency virus neutralizing antibodies recognize several conserved domains on the envelope glycoproteins. Journal of Virology. https://doi.org/10.1128/jvi.61.6.2024-2028.1987
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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