The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Broadly Neutralizing Antibodies Elicited by the Hypervariable Neutralizing Determinant of HIV-1
Abstract
The principal neutralizing determinant (PND) of human immunodeficiency virus (HIV)-1 resides within the V 3 loop of the envelope protein. Antibodies elicited by peptides of this region were able to neutralize diverse isolates. Serum from one of three animals immunized with the human T cell lymphoma virus (HTLV)- III MN PND peptide, RP142, neutralized MN and the sequence-divergent HTLV- III B isolate. Serum from one of three animals immunized with a 13-amino acid III B PND peptide (RP337) also neutralized both of these isolates. Characterization of these sera revealed that the cross-neutralizing antibodies bound the amino acid sequence GlyProGlyArgAlaPhe (GPGRAF) that is present in both isolates. This sequence is frequently found in the PNDs analyzed in randomly selected HIV-1 isolates. Sera from two rabbits immunized with a peptide containing only the GPGRAF residues neutralized divergent isolates, including III B and MN.
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Cites
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Self-citationHTLV-III/LAV-Neutralizing Antibodies to an E. coli -Produced Fragment of the Virus Envelope
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Cited by
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Kulkarni, P. S., Hurwitz, J. L., Simões, E. A. F., & Piedra, P. A. (2018) · Viral Immunology · doi:10.1089/vim.2017.0147 · Cited by 53
Metadata
- Authors
- Javaherian, K., Langlois, A. J., LaRosa, G. J., Profy, A. T., Bolognesi, D. P., Herlihy, W. C., Putney, S. D., & Matthews, T. J.
- Venue
- Science
- Published
- 1990-12-14
- Volume
- 250
- Issue
- 4987
- Pages
- 1590-1593
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2068490834
- Cited by
- 353
- References
- 14
- FWCI
- 12.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Javaherian, K., Langlois, A. J., LaRosa, G. J., Profy, A. T., Bolognesi, D. P., Herlihy, W. C., Putney, S. D., & Matthews, T. J. (1990). Broadly Neutralizing Antibodies Elicited by the Hypervariable Neutralizing Determinant of HIV-1. Science. https://doi.org/10.1126/science.1703322
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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