The DOI matches its Crossref record.
Human papillomavirus type 16 open reading frame E7 encodes a transforming gene for rat 3Y1 cells
Abstract
Human papillomavirus type 16 (HPV 16) DNA is capable of morphologically transforming rat 3Y1 cells. The expression plasmids, constructed from the simian virus 40-based expression vector pSV2-0 and specific DNA fragments from the putative early region of the HPV 16 genome, were tested for their transforming capacity. Among the various pSV2 plasmids, only those containing the intact E7 coding region were found to produce foci of the transformed rat cells which could grow in a soft-agar medium. The data indicate that expression of the HPV 16 E7 open reading frame is sufficient to induce focal transformation of rat cells.
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“subsequently, E7 was recognized as the major transforming protein of high-risk HPVs, using mutational analyses in transformation assays [52,79,80,81,82,83,84]”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [80]
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Cited by
The human papilloma virus-16 E7-oncoprotein is able to bind to the retinoblastoma gene product
Dyson, N., Howley, P. M., Münger, K., & Harlow, E. (1989) · Science · doi:10.1126/science.2537532 · Cited by 3,017
Basukala, O., & Banks, L. (2021) · Viruses · doi:10.3390/v13101892 · Cited by 137
Metadata
- Authors
- Kanda, T., Furuno, A., & Yoshiike, K.
- Affiliations
- Department of Enteroviruses, National Institute of Health, Tokyo, Japan.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1988-02
- Volume
- 62
- Issue
- 2
- Pages
- 610-613
- ISSN
- 0022-538X
- 1098-5514
- Cited by
- 119
- References
- 0
- Language
- en
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