The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Mutational analysis of the conserved basic domain of human immunodeficiency virus tat protein
Open accessAbstract
The tat trans-activators encoded by the known strains of primate immunodeficiency virus share a conserved, highly basic protein domain. Mutagenesis of this sequence in the tat gene of human immunodeficiency virus type 1 is shown here to reduce, but not eliminate, the trans-activation of human immunodeficiency virus type 1-specific gene expression. The degree of inhibition is shown to vary in a dose-dependent manner and is most marked at low levels of tat expression. Multiple mutations of the basic domain of tat were found to impair both the in vivo stability and the nuclear localization of the tat protein. It is proposed that this protein domain serves to efficiently target the tat gene product to its appropriate site or substrate within the nucleus of expressing cells.
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Cites
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Cited by
Tat trans-activates the human immunodeficiency virus through a nascent RNA target
Berkhout, B., Silverman, R. H., & Jeang, K.-T. (1989) · Cell · doi:10.1016/0092-8674(89)90289-4 · Cited by 647
Delivery of bioactive molecules into the cell: the Trojan horse approach
Dietz, G. P. H., & Bähr, M. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.03.005 · Cited by 469
Fragments of the HIV-1 Tat Protein Specifically Biand TAR RNA
Weeks, K. M., Ampe, C., Schultz, S. C., Steitz, T. A., & Crothers, D. M. (1990) · Science · doi:10.1126/science.2205002 · Cited by 444
Multifaceted Activities of the HIV-1 Transactivator of Transcription, Tat
Jeang, K.-T., Xiao, H., & Rich, E. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.28837 · Cited by 414
Nuclear and nucleolar targeting sequences of c-erb-A, c-myb, N-myc, p53, HSP70, and HIV tat proteins
Dang, C. V., & Lee, W. M. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84673-2 · Cited by 347
Metadata
- Authors
- Hauber, J., Malim, M. H., & Cullen, B. R.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1989-03
- Volume
- 63
- Issue
- 3
- Pages
- 1181-1187
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1591626938
- Cited by
- 277
- References
- 35
- FWCI
- 7.02
- Type
- journal article
- Language
- en
- Open access
- green
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- Hauber, J., Malim, M. H., & Cullen, B. R. (1989). Mutational analysis of the conserved basic domain of human immunodeficiency virus tat protein. Journal of Virology. https://doi.org/10.1128/jvi.63.3.1181-1187.1989
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
